Transcriptional Addiction in Cancer by Bradner, James E., Hnisz, Denes, Young, Richard A.

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Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions by Ji, Xiong, Abraham, Brian J., Lee, Tong Ihn, Jaenisch, Rudolf, Bradner, James E., Young, Richard A., Dadon, Daniel Benjamin

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Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers by Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Weintraub, Abraham Selby, Young, Richard A.

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Models of human core transcriptional regulatory circuitries by Saint-André, Violaine, Federation, Alexander J., Lin, Charles Y., Abraham, Brian J., Lee, Tong Ihn, Bradner, James E., Reddy, Jessica, Young, Richard A.

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Transcriptional Amplification in Tumor Cells with Elevated c-Myc by Lin, Charles Y., Loven, Jakob, Rahl, Peter B., Paranal, Ronald M., Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers by Loven, Jakob, Hoke, Heather Ashley, Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

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Selective targeting of MYC mRNA by stabilized antisense oligonucleotides by Gill, Taylor, Wang, Haichuan, Bandaru, Raj, Lawlor, Matthew, Lu, Chenyue, Nieman, Linda T, Tao, Junyan, Zhang, Yixian, Anderson, Daniel G, Ting, David T, Chen, Xin, Bradner, James E, Ott, Christopher J

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Genome-wide localization of small molecules by Anders, Lars, Guenther, Matthew G., Qi, Jun, Fan, Zi Peng, Marineau, Jason J, Rahl, Peter B, Sigova, Alla A, Smith, William B, Lee, Tong Ihn, Bradner, James E., Young, Richard A., Loven, Jakob

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Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma by Fulciniti, Mariateresa, Lin, Charles Y., Samur, Mehmet K., Lopez, Michael A., Singh, Irtisha, Lawlor, Matthew A., Szalat, Raphael E., Ott, Christopher J., Avet-Loiseau, Herve’, Anderson, Kenneth C., Young, Richard A., Bradner, James E., Munshi, Nikhil C.

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BET bromodomain proteins regulate enhancer function during adipogenesis by Brown, Jonathan D., Feldman, Zachary B., Doherty, Sean P., Reyes, Jaime M., Rahl, Peter B., Lin, Charles Y., Sheng, Quanhu, Duan, Qiong, Federation, Alexander J., Kung, Andrew L., Haldar, Saptarsi M., Plutzky, Jorge, Bradner, James E., Young, Richard A.

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation by Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Bradner, James E, Winter, Georg E, Gray, Nathanael S, Young, Richard A.

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YY1 Is a Structural Regulator of Enhancer-Promoter Loops by Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Bradner, James E., Gray, Nathanael S., Weintraub, Abraham Selby, Li, Charles Han, Zamudio Montes de Oca, Alicia, Jaenisch, Rudolf, Young, Richard A.

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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma by Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E., Young, Richard A.

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Transcription control by the ENL YEATS domain in acute leukaemia by Erb, Michael A., Scott, Thomas G., Li, Bin E., Xie, Huafeng, Paulk, Joshiawa, Seo, Hyuk-Soo, Souza, Amanda, Roberts, Justin M., Dastjerdi, Shiva, Buckley, Dennis L., Nabet, Behnam, Zeid, Rhamy, Offei-Addo, Nana K., Dhe-Paganon, Sirano, Orkin, Stuart H., Winter, Georg E., Bradner, James E., Sanjana, Neville E, Shalem, Ophir, Zhang, Feng

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Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer by Dowling, Catríona M, Hollinshead, Kate ER, Di Grande, Alessandra, Pritchard, Justin, Zhang, Hua, Dillon, Eugene T, Haley, Kathryn, Papadopoulos, Eleni, Mehta, Anita K, Bleach, Rachel, Lindner, Andreas U, Mooney, Brian, Düssmann, Heiko, O’Connor, Darran, Prehn, Jochen HM, Wynne, Kieran, Hemann, Michael, Bradner, James E, Kimmelman, Alec C, Guerriero, Jennifer L, Cagney, Gerard, Wong, Kwok-Kin, Letai, Anthony G, Chonghaile, Tríona Ní

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Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer by Dowling, Catríona M., Hollinshead, Kate E. R., Di Grande, Alessandra, Pritchard, Justin, Zhang, Hua, Dillon, Eugene T., Haley, Kathryn, Papadopoulos, Eleni, Mehta, Anita K., Bleach, Rachel, Lindner, Andreas U., Mooney, Brian, Düssmann, Heiko, O’Connor, Darran, Prehn, Jochen H. M., Wynne, Kieran, Hemann, Michael, Bradner, James E., Kimmelman, Alec C., Guerriero, Jennifer L., Cagney, Gerard, Wong, Kwok-Kin, Letai, Anthony G., Chonghaile, Tríona Ní

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Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor by Christensen, Camilla L., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Wong, Kwok-Kin, Kwiatkowski, Nick, Abraham, Brian Joseph, Young, Richard A.

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc by Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.

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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling by Floyd, Scott R., Pacold, Michael E., Huang, Qiuying, Clarke, Scott M., Rameseder, Jonathan, Lee, Michael J., Blake, Emily J., Fydrych, Anna, Ho, Richard, Del Rosario, Amanda M., Root, David E., Carpenter, Anne E., Hahn, William C., Sabatini, David M., Chen, Clark C., White, Forest M., Bradner, James E., Yaffe, Michael B., Lam, Fred Chiu-Lai, Cannell, Ian Gordon, Bryson, Bryan D., Greenberger, Benjamin Aaron, Chen, Grace, Maffa, Amanda D.

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Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma by Mazur, Pawel K., Herner, Alexander, Mello, Stephano S., Wirth, Matthias, Hausmann, Simone, Lofgren, Shane M., Kuschma, Timo, Hahn, Stephan A., Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noel, Peter B., Braren, Rickmer, Erkan, Mert, Kleeff, Jorg, Sipos, Bence, Sayles, Leanne C., Heikenwalder, Mathias, Hessmann, Elizabeth, Ellenrieder, Volker, Esposito, Irene, Bradner, James E., Khatri, Purvesh, Sweet-Cordero, E Alejandro, Attardi, Laura D., Schmid, Roland M., Schneider, Guenter, Sage, Julien, Siveke, Jens T., Sanchez-Rivera, Francisco Javier, Jacks, Tyler E.

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