Genomic risk scores and oral contraceptive-associated ischemic stroke risk: a call for collaboration af Forrest Lin, Liisa Tomppo, Brady Gaynor, Kathleen Ryan, John W. Cole, John W. Cole, Braxton D. Mitchell, Braxton D. Mitchell, Jukka Putaala, Steven J. Kittner

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Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip. af Ankita eParihar, G. Craig eWood, Xin eChu, Qunjan eJin, George eArgyropoulos, Christopher D. Still, Alan eShuldiner, Alan eShuldiner, Braxton D Mitchell, Braxton D Mitchell, Glenn S. Gerhard

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Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia[S] af Elizabeth A. O'Hare, Xiaochun Wang, May E. Montasser, Yen-Pei C. Chang, Braxton D. Mitchell, Norann A. Zaghloul

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Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish af Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell

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Acute pharmacodynamic responses to sitagliptin: Drug‐induced increase in early insulin secretion in oral glucose tolerance test af Amber L. Beitelshees, Elizabeth A. Streeten, Zhinous Shahidzadeh Yazdi, Hilary B. Whitlatch, Braxton D. Mitchell, Alan R. Shuldiner, May E. Montasser, Simeon I. Taylor

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Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians af Liubov Arbeeva, Michelle Yau, Braxton D. Mitchell, Rebecca D. Jackson, Kathleen Ryan, Yvonne M. Golightly, Marian T. Hannan, Amanda Nelson, Joanne M. Jordan, Marc C. Hochberg

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Gender differences in first and secondhand smoke exposure, spirometric lung function and cardiometabolic health in the old order Amish: A novel population without female smoking. af Robert M Reed, Mark T Dransfield, Michael Eberlein, Michael Miller, Giora Netzer, Mary Pavlovich, Toni I Pollin, Steven M Scharf, Alan R Shuldiner, Don Sin, Braxton D Mitchell

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Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset af Joanna von Berg, Joanna von Berg, Patrick F. McArdle, Paavo Häppölä, Jeffrey Haessler, Charles Kooperberg, Robin Lemmens, Robin Lemmens, Alessandro Pezzini, Alessandro Pezzini, Vincent Thijs, Vincent Thijs, Vincent Thijs, Sara L. Pulit, Steven J. Kittner, Steven J. Kittner, Braxton D. Mitchell, Braxton D. Mitchell, Jeroen de Ridder, Jeroen de Ridder, Sander W. van der Laan, Sander W. van der Laan

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Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation af Shabnam Salimi, Joshua P. Lewis, Laura M. Yerges‐Armstrong, Braxton D. Mitchell, Faisal Saeed, Jeffry R. O'Connell, James A. Perry, Kathleen A. Ryan, Alan R. Shuldiner, Afshin Parsa

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Missense variants in SORT1 are associated with LDL-C in an Amish population af Kelly A. Mitok, Kathryn L. Schueler, Sarah M. King, Joseph Orr, Kathleen A. Ryan, Mark P. Keller, Ronald M. Krauss, Braxton D. Mitchell, Alan R. Shuldiner, Alan D. Attie

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Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics af Joshua P. Lewis, Kathleen A. Ryan, Elizabeth A. Streeten, Hilary B. Whitlatch, Melanie Daue, Keith Tanner, James A. Perry, Jeffrey R. O'Connell, Alan R. Shuldiner, Braxton D. Mitchell

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Living the good life? Mortality and hospital utilization patterns in the Old Order Amish. af Braxton D Mitchell, Woei-Jyh Lee, Magdalena I Tolea, Kelsey Shields, Zahra Ashktorab, Laurence S Magder, Kathleen A Ryan, Toni I Pollin, Patrick F McArdle, Alan R Shuldiner, Alejandro A Schäffer

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Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome af Bin Ni, Shanshan Chen, Kathleen A. Ryan, Michael L. Maitland, Jared S. Farrar, Martin Witzenrath, Birgitt Gubier, Cindy Serdjebi, Karine Bertotti, Rui Wang, Fadi N. Salloum, Luigi Marino, Braxton D. Mitchell, Francesco S. Celi

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Circulating CD34+ Cell Count is Associated with Extent of Subclinical Atherosclerosis in Asymptomatic Amish Men, Independent of 10-Year Framingham Risk af Lawrence F. Bielak D.D.S., M.P.H., Richard B. Horenstein, Kathleen A. Ryan, Patrick F. Sheedy, John A. Rumberger, Keith Tanner, Wendy Post, Braxton D. Mitchell, Alan R. Shuldiner, Patricia A. Peyser

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Prevalence, control, and treatment of diabetes, hypertension, and high cholesterol in the Amish af Shisi He, Kathleen A Ryan, Elizabeth A Streeten, Patrick F McArdle, Melanie Daue, Donna Trubiano, Yvonne Rohrer, Patrick Donnelly, Maryann Drolet, Sylvia Newcomer, Susan Shaub, Nancy Weitzel, Toni I Pollin, Braxton D Mitchell

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Bitter taste receptors influence glucose homeostasis. af Cedrick D Dotson, Lan Zhang, Hong Xu, Yu-Kyong Shin, Stephan Vigues, Sandra H Ott, Amanda E T Elson, Hyun Jin Choi, Hillary Shaw, Josephine M Egan, Braxton D Mitchell, Xiaodong Li, Nanette I Steinle, Steven D Munger

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Rare variants in ischemic stroke: an exome pilot study. af John W Cole, O Colin Stine, Xinyue Liu, Abhishek Pratap, Yuching Cheng, Luke J Tallon, Lisa K Sadzewicz, Nicole Dueker, Marcella A Wozniak, Barney J Stern, James F Meschia, Braxton D Mitchell, Steven J Kittner, Jeffrey R O'Connell

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Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndrome. af Margaret L Zupancic, Brandi L Cantarel, Zhenqiu Liu, Elliott F Drabek, Kathleen A Ryan, Shana Cirimotich, Cheron Jones, Rob Knight, William A Walters, Daniel Knights, Emmanuel F Mongodin, Richard B Horenstein, Braxton D Mitchell, Nanette Steinle, Soren Snitker, Alan R Shuldiner, Claire M Fraser

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An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort af Xin Geng, Marguerite R. Irvin, Bertha Hidalgo, Stella Aslibekyan, Vinodh Srinivasasainagendra, Ping An, Alexis C. Frazier-Wood, Hemant K. Tiwari, Tushar Dave, Kathleen Ryan, Jose M. Ordovas, Robert J. Straka, Mary F. Feitosa, Paul N. Hopkins, Ingrid Borecki, Michael A. Province, Braxton D. Mitchell, Donna K. Arnett, Degui Zhi

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An Exome-Wide Sequencing Study of the GOLDN Cohort Reveals Novel Associations of Coding Variants and Fasting Plasma Lipids af Xin Geng, Xin Geng, Marguerite R. Irvin, Bertha Hidalgo, Stella Aslibekyan, Vinodh Srinivasasainagendra, Ping An, Alexis C. Frazier-Wood, Hemant K. Tiwari, Tushar Dave, Kathleen Ryan, Jose M. Ordovas, Jose M. Ordovas, Jose M. Ordovas, Robert J. Straka, Mary F. Feitosa, Paul N. Hopkins, Ingrid Borecki, Michael A. Province, Braxton D. Mitchell, Donna K. Arnett, Degui Zhi, Degui Zhi

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