Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). حسب Neil Auricchio, Izabela Malinowska, Reuben Shaw, Brendan D Manning, David J Kwiatkowski

احصل على النص الكامل

The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo حسب Eylul Harputlugil, Christopher Hine, Dorathy Vargas, Lauren Robertson, Brendan D. Manning, James R. Mitchell

احصل على النص الكامل

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. حسب Hui H Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M Squillace, Chin-Lee Wu, Brendan D Manning

احصل على النص الكامل

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels حسب Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning

احصل على النص الكامل

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals حسب Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning

احصل على النص الكامل

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin حسب Vanessa Byles, Yann Cormerais, Krystle Kalafut, Victor Barrera, James E. Hughes Hallett, Shannan Ho Sui, John M. Asara, Christopher M. Adams, Gerta Hoxhaj, Issam Ben-Sahra, Brendan D. Manning

احصل على النص الكامل

The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth حسب Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell, Aaron M. Hosios, Maria Osipovich, Margaret E. Torrence, James R. Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D. Manning

احصل على النص الكامل

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex حسب Molly C. McNamara, Aaron M. Hosios, Margaret E. Torrence, Ting Zhao, Cameron Fraser, Meghan Wilkinson, David J. Kwiatkowski, Elizabeth P. Henske, Chin-Lee Wu, Kristopher A. Sarosiek, Alexander J. Valvezan, Brendan D. Manning

احصل على النص الكامل

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation حسب Anthony J Covarrubias, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, Issam Ben-Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul, Erika C Espinosa, Dudley Lamming, Brendan D Manning, Yijing Zhang, Ian A Blair, Tiffany Horng

احصل على النص الكامل

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway حسب Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj

احصل على النص الكامل