Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). por Neil Auricchio, Izabela Malinowska, Reuben Shaw, Brendan D Manning, David J Kwiatkowski

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The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo por Eylul Harputlugil, Christopher Hine, Dorathy Vargas, Lauren Robertson, Brendan D. Manning, James R. Mitchell

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Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. por Hui H Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M Squillace, Chin-Lee Wu, Brendan D Manning

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The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels por Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning

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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals por Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning

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Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin por Vanessa Byles, Yann Cormerais, Krystle Kalafut, Victor Barrera, James E. Hughes Hallett, Shannan Ho Sui, John M. Asara, Christopher M. Adams, Gerta Hoxhaj, Issam Ben-Sahra, Brendan D. Manning

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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth por Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell, Aaron M. Hosios, Maria Osipovich, Margaret E. Torrence, James R. Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D. Manning

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex por Molly C. McNamara, Aaron M. Hosios, Margaret E. Torrence, Ting Zhao, Cameron Fraser, Meghan Wilkinson, David J. Kwiatkowski, Elizabeth P. Henske, Chin-Lee Wu, Kristopher A. Sarosiek, Alexander J. Valvezan, Brendan D. Manning

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Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation por Anthony J Covarrubias, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, Issam Ben-Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul, Erika C Espinosa, Dudley Lamming, Brendan D Manning, Yijing Zhang, Ian A Blair, Tiffany Horng

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Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway por Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj

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