Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). 著者: Neil Auricchio, Izabela Malinowska, Reuben Shaw, Brendan D Manning, David J Kwiatkowski

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The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo 著者: Eylul Harputlugil, Christopher Hine, Dorathy Vargas, Lauren Robertson, Brendan D. Manning, James R. Mitchell

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Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. 著者: Hui H Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M Squillace, Chin-Lee Wu, Brendan D Manning

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The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels 著者: Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning

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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals 著者: Margaret E Torrence, Michael R MacArthur, Aaron M Hosios, Alexander J Valvezan, John M Asara, James R Mitchell, Brendan D Manning

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Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin 著者: Vanessa Byles, Yann Cormerais, Krystle Kalafut, Victor Barrera, James E. Hughes Hallett, Shannan Ho Sui, John M. Asara, Christopher M. Adams, Gerta Hoxhaj, Issam Ben-Sahra, Brendan D. Manning

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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth 著者: Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell, Aaron M. Hosios, Maria Osipovich, Margaret E. Torrence, James R. Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D. Manning

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex 著者: Molly C. McNamara, Aaron M. Hosios, Margaret E. Torrence, Ting Zhao, Cameron Fraser, Meghan Wilkinson, David J. Kwiatkowski, Elizabeth P. Henske, Chin-Lee Wu, Kristopher A. Sarosiek, Alexander J. Valvezan, Brendan D. Manning

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Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation 著者: Anthony J Covarrubias, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, Issam Ben-Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul, Erika C Espinosa, Dudley Lamming, Brendan D Manning, Yijing Zhang, Ian A Blair, Tiffany Horng

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Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway 著者: Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj

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