A novel ultrasound-guided mouse model of sudden cardiac arrest. by Cody A Rutledge, Takuto Chiba, Kevin Redding, Cameron Dezfulian, Sunder Sims-Lucas, Brett A Kaufman

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Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction by Cody Rutledge, George Cater, Brenda McMahon, Lanping Guo, Seyed Mehdi Nouraie, Yijen Wu, Flordeliza Villanueva, Brett A. Kaufman

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Single-Step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Editing Events In Vivo by Micol Falabella, Linqing Sun, Justin Barr, Andressa Z. Pena, Erin E. Kershaw, Sebastien Gingras, Elena A. Goncharova, Brett A. Kaufman

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Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest by Cody A. Rutledge, Claudia Lagranha, Takuto Chiba, Kevin Redding, Donna B. Stolz, Eric Goetzman, Sunder Sims-Lucas, Brett A. Kaufman

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Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration by Daniel S. de Jesus, Evan DeVallance, Yao Li, Micol Falabella, Danielle Guimaraes, Sruti Shiva, Brett A. Kaufman, Mark T. Gladwin, Patrick J. Pagano

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Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis by Vaibhav Sidarala, Jie Zhu, Elena Levi-D’Ancona, Gemma L. Pearson, Emma C. Reck, Emily M. Walker, Brett A. Kaufman, Scott A. Soleimanpour

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Cell-free DNA levels associate with COPD exacerbations and mortality by Sarah A. Ware, Corrine R. Kliment, Luca Giordano, Kevin M. Redding, William L. Rumsey, Stewart Bates, Yingze Zhang, Frank C. Sciurba, S. Mehdi Nouraie, Brett A. Kaufman

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Functional characterization of variants of unknown significance in a spinocerebellar ataxia patient using an unsupervised machine learning pipeline by Siddharth Nath, Nicholas S. Caron, Linda May, Oxana B. Gluscencova, Jill Kolesar, Lauren Brady, Brett A. Kaufman, Gabrielle L. Boulianne, Amadeo R. Rodriguez, Mark A. Tarnopolsky, Ray Truant

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Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function by Gaochao Tian, Steven R. Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia M. Davis, Sam Duvall, Brett A. Kaufman, William L. Rumsey

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Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood by Kalpita Rashmi Karan, Caroline Trumpff, Marlon A. McGill, Jacob E. Thomas, Gabriel Sturm, Vincenzo Lauriola, Richard P. Sloan, Nicolas Rohleder, Brett A. Kaufman, Anna L. Marsland, Martin Picard

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Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance by Lia R. Edmunds, Bingxian Xie, Amanda M. Mills, Brydie R. Huckestein, Ramya Undamatla, Anjana Murali, Martha M. Pangburn, James Martin, Ian Sipula, Brett A. Kaufman, Iain Scott, Michael J. Jurczak

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Extracellular Release of Mitochondrial DNA: Triggered by Cigarette Smoke and Detected in COPD by Luca Giordano, Alyssa D. Gregory, Mireia Pérez Verdaguer, Sarah A. Ware, Hayley Harvey, Evan DeVallance, Tomasz Brzoska, Prithu Sundd, Yingze Zhang, Frank C. Sciurba, Steven D. Shapiro, Brett A. Kaufman

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hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction. by Manti Guha, Satish Srinivasan, F Bradley Johnson, Gordon Ruthel, Kip Guja, Miguel Garcia-Diaz, Brett A Kaufman, M Rebecca Glineburg, JiKang Fang, Hiroshi Nakagawa, Jeelan Basha, Tapas Kundu, Narayan G Avadhani

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Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance. by Frances R Belmonte, Nikolaos Dedousis, Ian Sipula, Nikita A Desai, Aatur D Singhi, Yanxia Chu, Yingze Zhang, Sylvie Bannwarth, Véronique Paquis-Flucklinger, Lea Harrington, Sruti Shiva, Michael J Jurczak, Robert M O'Doherty, Brett A Kaufman

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Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart by Manling Zhang, Ning Feng, Zishan Peng, Dharendra Thapa, Michael W. Stoner, Janet R. Manning, Charles F. McTiernan, Xue Yang, Michael J. Jurczak, Danielle Guimaraes, Krithika Rao, Sruti Shiva, Brett A. Kaufman, Michael N. Sack, Iain Scott

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PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses. by Marta Bueno, Daniel Zank, Ivette Buendia-Roldán, Kaitlin Fiedler, Brenton G Mays, Diana Alvarez, John Sembrat, Brian Kimball, Jordan K Bullock, James L Martin, Mehdi Nouraie, Brett A Kaufman, Mauricio Rojas, Annie Pardo, Moisés Selman, Ana L Mora

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A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. by Jitendra S Kanshana, Polly E Mattila, Michael C Ewing, Ashlee N Wood, Gabriele Schoiswohl, Anna C Meyer, Aneta Kowalski, Samantha L Rosenthal, Sebastien Gingras, Brett A Kaufman, Ray Lu, Daniel E Weeks, Stephen T McGarvey, Ryan L Minster, Nicola L Hawley, Erin E Kershaw

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A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations by Gabriel Sturm, Anna S. Monzel, Kalpita R. Karan, Jeremy Michelson, Sarah A. Ware, Andres Cardenas, Jue Lin, Céline Bris, Balaji Santhanam, Michael P. Murphy, Morgan E. Levine, Steve Horvath, Daniel W. Belsky, Shuang Wang, Vincent Procaccio, Brett A. Kaufman, Michio Hirano, Martin Picard

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Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death by Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub

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OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases by Gabriel Sturm, Kalpita R. Karan, Anna S. Monzel, Balaji Santhanam, Tanja Taivassalo, Céline Bris, Sarah A. Ware, Marissa Cross, Atif Towheed, Albert Higgins-Chen, Meagan J. McManus, Andres Cardenas, Jue Lin, Elissa S. Epel, Shamima Rahman, John Vissing, Bruno Grassi, Morgan Levine, Steve Horvath, Ronald G. Haller, Guy Lenaers, Douglas C. Wallace, Marie-Pierre St-Onge, Saeed Tavazoie, Vincent Procaccio, Brett A. Kaufman, Erin L. Seifert, Michio Hirano, Martin Picard

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