Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors. by Nagase, H, Brew, K

The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. by Brew, K, Nagase, H

Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics. by Nagase, H, Brew, K

Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synt... by Pike, A, Brew, K, Acharya, K

Tissue inhibitors of metalloproteinases: evolution, structure and function. by Brew, K, Dinakarpandian, D, Nagase, H

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). by Kashiwagi, M, Tortorella, M, Nagase, H, Brew, K

Study by mutagenesis of the roles of two aromatic clusters of alpha-lactalbumin in aspects of its action in the lactose synthase system. by Grobler, J, Wang, M, Pike, A, Brew, K

Engineering and expression of ADAMTS-4 and ADAMTS-5, proteolytic enzymes involved in osteoarthritis progression by Lauer-Fields, J, Nagase, H, Fields, G, Brew, K

Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain. In search of selective matrix metalloproteinase inhibitors. by Wei, S, Chen, Y, Chung, L, Nagase, H, Brew, K

Characterisation of N-TIMP-3 mutants that selectively inhibit the ADAMTSs by Lim, N, Kashiwagi, M, Wei, S, Brew, K, Nagase, H

Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not tumor necrosis factor-alpha-converting enzyme. by Wei, S, Kashiwagi, M, Kota, S, Xie, Z, Nagase, H, Brew, K

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) - Physiological roles and structural basis of MMP inhibition by TIMP-1 by Nagase, H, Das, S, Dey, S, Fowlkes, J, Huang, W, Brew, K

Selective inhibition of matrix metalloproteinase-2 and-9 by phosphinic acid pseudo-peptides containing triple-helical structure by Lauer-Fields, J, Hammer, R, Brew, K, Nagase, H, Fields, G

E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A). by Troeberg, L, Tanaka, M, Wait, R, Shi, Y, Brew, K, Nagase, H

Rapid collapse and slow structural reorganisation during the refolding of bovine alpha-lactalbumin. by Forge, V, Wijesinha, RT, Balbach, J, Brew, K, Robinson, C, Redfield, C, Dobson, C

Catalytic properties of ADAM12 and its domain deletion mutants. by Jacobsen, J, Visse, R, Sørensen, H, Enghild, J, Brew, K, Wewer, U, Nagase, H

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications. by Lim, N, Kashiwagi, M, Visse, R, Jones, J, Enghild, J, Brew, K, Nagase, H

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. by Minond, D, Lauer-Fields, J, Cudic, M, Overall, C, Pei, D, Brew, K, Visse, R, Nagase, H, Fields, G

A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons by Ould-Yahoui, A, Tremblay, E, Sbai, O, Ferhat, L, Bernard, A, Charrat, E, Gueye, Y, Lim, N, Brew, K, Risso, J, Dive, V, Khrestchatisky, M, Rivera, S

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. by Kopitz, C, Gerg, M, Bandapalli, O, Ister, D, Pennington, C, Hauser, S, Flechsig, C, Krell, H, Antolovic, D, Brew, K, Nagase, H, Stangl, M, von Weyhern, C, Brücher, B, Brand, K, Coussens, L, Edwards, DR, Krüger, A