Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation by Brewitz, L, Onisko, BC, Schofield, CJ

Kinetic parameters of human aspartate/asparagine-β-hydroxylase suggest that it has a possible function in oxygen sensing by Brewitz, L, Tumber, A, Schofield, CJ

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase by Brewitz, L, Nakashima, Y, Schofield, C

Novel 2-oxoglutarate analogues modulate the epigenetic activity of the cancer-related human enzyme aspartate/asparagine-β-hydroxylase by Brewitz, L, Tumber, A, Nakashima, Y, Schofield, CJ

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylas by Brewitz, L, Tumber, A, Zhang, X, Schofield, C

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases by Brewitz, L, Nakashima, Y, Tumber, A, Salah, E, Schofield, CJ

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases by Nakashima, Y, Brewitz, L, Tumber, A, Salah, E, Schofield, C

Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5 by Tumber, A, Saleh, E, Brewitz, L, Corner, TP, Schofield, CJ

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors by Brewitz, L, Tumber, A, Pfeffer, I, McDonough, M, Schofield, C

Human prolyl hydroxylase domain 2 reacts with O 2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes by Fiorini, G, Marshall, SA, Figg, WD, Myers, WK, Brewitz, L, Schofield, CJ

Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation by Gayatri, Brewitz, L, Ibbotson, L, Salah, E, Basak, S, Choudhry, H, Schofield, CJ

Synthesis of novel pyridine-carboxylates as small-molecule inhibitors of human aspartate/asparagine-β-hydroxylase by Brewitz, L, Tumber, A, Thalhammer, A, Salah, E, Christensen, KE, Schofield, C

Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein by Chan, HTH, Brewitz, L, Lukacik, P, Strain-Damerell, C, Walsh, MA, Schofield, CJ, Duarte, F

Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate... by Brewitz, L, Chan, HTH, Lukacik, P, Strain-Damerell, C, Walsh, MA, Duarte, F, Schofield, CJ

αβ,α'β'-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes by de Munnik, M, Lithgow, J, Brewitz, L, Christensen, KE, Bates, RH, Rodriguez-Miquel, B, Schofield, CJ

Human oxygenase variants employing a single protein Fe(II) ligand are catalytically active by Brasnett, A, Pfeffer, I, Brewitz, L, Chowdhury, R, Nakashima, Y, Tumber, A, McDonough, MA, Schofield, CJ

Structure-activity studies reveal scope for optimisation of Ebselen-type inhibition of SARS-COV-2 main protease by Thun-Hohenstein, STD, Suits, TF, Malla, TR, Tumber, A, Brewitz, L, Salah, E, Choudhry, H, Schofield, C

Human oxygenase variants employing a single protein Fe(II) ligand are catalytically active by Brasnett, A, Pfeffer, I, Brewitz, L, Chowdhury, R, Nakashima, Y, Tumber, A, McDonough, M, Schofield, C

Structure-activity studies reveal scope for optimisation of Ebselen-type inhibition of SARS-COV-2 main protease by Thun-Hohenstein, STD, Suits, TF, Malla, TR, Tumber, A, Brewitz, L, Choudhry, H, Salah, E, Schofield, CJ

Mass spectrometric assays reveal discrepancies in inhibition profiles for the SARS-CoV-2 papain-like protease by Brewitz, L, Kamps, JJAG, Lukacik, P, Strain-Dammerell, C, Zhao, Y, Tumber, A, Malla, T, Orville, A, Walsh, M, Schofield, C