Naked antibodies and antibody-drug conjugates: targeted therapy for childhood acute lymphoblastic leukemia by Erica Brivio, Francisco Bautista, C. Michel Zwaan

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NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities by Milad Rasouli, Selina Troester, Florian Grebien, Bianca F. Goemans, C. Michel Zwaan, Olaf Heidenreich

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Methotrexate-induced side effects are not due to differences in pharmacokinetics in children with Down syndrome and acute lymphoblastic leukemia by Trudy D. Buitenkamp, Ron A.A. Mathôt, Valerie de Haas, Rob Pieters, C. Michel Zwaan

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Ibrutinib is not an effective drug in primografts of TCF3-PBX1 by Cesca van de Ven, Aurélie Boeree, Femke Stalpers, C. Michel Zwaan, Monique L. Den Boer

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Case Report: Immune dysregulation associated with long-lasting regression of a (pre)leukemic clone by Joost B. Koedijk, Joost B. Koedijk, Thomas B. van Beek, Marijn A. Vermeulen, Lennart A. Kester, Elizabeth K. Schweighart, Stefan Nierkens, Stefan Nierkens, Mirjam E. Belderbos, C. Michel Zwaan, C. Michel Zwaan, Katja M. J. Heitink-Pollé, Olaf Heidenreich, Olaf Heidenreich

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Outcome of children with relapsed acute myeloid leukemia improved over time in the Netherlands between 1998 and 2018 by Jasper J. van de Pol, Maya Schulpen, Bianca F. Goemans, Gertjan Kaspers, Henrike E. Karim-Kos, C. Michel Zwaan

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Low frequency of type-I and type-II aberrations in myeloid leukemia of Down syndrome, underscoring the unique entity of this disease by Marjolein Blink, Marry M. van den Heuvel-Eibrink, Valerie de Haas, Jan-Henning Klusmann, Henrik Hasle, C. Michel Zwaan

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NRIP3: a novel translocation partner of MLL detected in a pediatric acute myeloid leukemia with complex chromosome 11 rearrangements by Brian V. Balgobind, C. Michel Zwaan, Claus Meyer, Rolf Marschalek, Rob Pieters, H. Berna Beverloo, Marry M. Van den Heuvel-Eibrink

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The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML by Milad Rasouli, Helen Blair, Selina Troester, Katarzyna Szoltysek, Rachel Cameron, Minoo Ashtiani, Anja Krippner-Heidenreich, Florian Grebien, Gerard McGeehan, C. Michel Zwaan, Olaf Heidenreich

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Targeted treatment options for paediatric B-cell precursor acute lymphoblastic leukaemia patients with constitutional or somatic chromosome 21 alterations by Naomi Michels, Femke M. Hormann, Aurélie Boeree, Edwin Sonneveld, Anthony V. Moorman, Gabriele Escherich, Rosemary Sutton, H. Berna Beverloo, Rob Pieters, C. Michel Zwaan, Monique L. den Boer, Judith M. Boer

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Low-dose cytarabine to prevent myeloid leukemia in children with Down syndrome: TMD Prevention 2007 study by Marius Flasinski, Kira Scheibke, Martin Zimmermann, Ursula Creutzig, Katarina Reinhardt, Femke Verwer, Valerie de Haas, Vincent H.J. van der Velden, Christine von Neuhoff, C. Michel Zwaan, Dirk Reinhardt, Jan-Henning Klusmann

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A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia. by Antonio C Arrieta, Lillian Sung, John S Bradley, C Michel Zwaan, Davis Gates, Hetty Waskin, Patricia Carmelitano, Andreas H Groll, Thomas Lehrnbecher, Eric Mangin, Amita Joshi, Nicholas A Kartsonis, Thomas J Walsh, Amanda Paschke

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Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis by Maite E. Houwing, Rowena L. Grohssteiner, Marjolein H. G. Dremmen, Ferdows Atiq, Wichor M. Bramer, Anne P. J. de Pagter, C. Michel Zwaan, Tonya J. H. White, Meike W. Vernooij, Marjon H. Cnossen

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P561: REVUMENIB IN PATIENTS WITH ACUTE LEUKEMIAS: COMPASSIONATE USE PROGRAM EXPERIENCE by Jeffrey Rubnitz, Ghayas C. Issa, Eytan M. Stein, Neerav Shukla, Wendy Stock, Andrius Žučenka, Sajad Khazal, Nandita Khera, Elliot Stieglitz, Jeremy Rubinstein, Galit Rosen, Rachel Ghiraldi, Huy Van Nguyen, Nicole Mcneer, C. Michel Zwaan

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Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia by Jasmijn D.E. de Rooij, Eva Beuling, Marry M. van den Heuvel-Eibrink, Askar Obulkasim, André Baruchel, Jan Trka, Dirk Reinhardt, Edwin Sonneveld, Brenda E.S. Gibson, Rob Pieters, Martin Zimmermann, C. Michel Zwaan, Maarten Fornerod

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Mapping epigenetic regulator gene mutations in cytogenetically normal pediatric acute myeloid leukemia by Daria G. Valerio, Jenny E. Katsman-Kuipers, Joop H. Jansen, Lonneke J. Verboon, Valerie de Haas, Jan Stary, André Baruchel, Martin Zimmermann, Rob Pieters, Dirk Reinhardt, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan

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Oncogenic and immunological targets for matched therapy of pediatric blood cancer patients: Dutch iTHER study experience by Judith M. Boer, Uri Ilan, Aurélie Boeree, Karin P. S. Langenberg, Jan Koster, Marco J. Koudijs, Jayne Y. Hehir‐Kwa, Stefan Nierkens, Corinne Rossi, Jan J. Molenaar, Bianca F. Goemans, Monique L. denBoer, C. Michel Zwaan

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Combination therapy with crizotinib and vinblastine for relapsed or refractory pediatric ALK-positive anaplastic large cell lymphoma by Fabian Knörr, Kim P.J. Schellekens, Reineke A. Schoot, Judith Landman-Parker, Heiko-Manuel Teltschik, Jan Förster, Amambay Riquelme, Alwin D.R. Huitema, Natasha K.A. van Eijkelenburg, Auke Beishuizen, C. Michel Zwaan, Wilhelm Woessmann, Jasper van der Lugt

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Gene expression profiles associated with pediatric relapsed AML. by Costa Bachas, Gerrit Jan Schuurhuis, C Michel Zwaan, Marry M van den Heuvel-Eibrink, Monique L den Boer, Eveline S J M de Bont, Zinia J Kwidama, Dirk Reinhardt, Ursula Creutzig, Valérie de Haas, Gertjan J L Kaspers, Jacqueline Cloos

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BCOR and BCORL1 mutations in pediatric acute myeloid leukemia by Jasmijn D.E. de Rooij, Marry M. van den Heuvel-Eibrink, Malou C.H. Hermkens, Lonneke J. Verboon, Susan T.C.J.M. Arentsen-Peters, Maarten Fornerod, Andre Baruchel, Jan Stary, Dirk Reinhardt, Valerie de Haas, Rob Pieters, C. Michel Zwaan

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