PI 3-kinase and disease by Cantley Lewis C

Altered metabolism in cancer by Locasale Jason W, Cantley Lewis C

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Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer by Murphy, Charles J., Karreth, Florian A., Elemento, Olivier, Toker, Alex, Wulf, Gerburg M., Cantley, Lewis C., Yang, Kangkang, Liu, Hui, Emdal, Kristina Bennet, Cantley, Lewis C, White, Forest M.

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Heterogeneity of tumor-induced gene expression changes in the human metabolic network by Hu, Jie, Locasale, Jason W., Bielas, Jason H., O'Sullivan, Jacintha, Sheahan, Kieran, Cantley, Lewis C., Vander Heiden, Matthew G., Vitkup, Dennis

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Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis by Locasale Jason W, Grassian Alexandra, Beroukhim Rameen, Meyerson Matthew, Wagner Gerhard, Asara John M, Brugge Joan S, Vander Heiden Matthew G, Cantley Lewis C

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis by Wang, Ying-Hua, Lee, Dongjun, Yu, Vionnie W.C., Jeanson, Nathaniel T., Clish, Clary B., Cantley, Lewis C., Scadden, David T., Israelsen, William James, Vander Heiden, Matthew G.

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The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling by Taniguchi, Cullen M., Winnay, Jonathon, Kondo, Tatsuya, Bronson, Roderick T., Guimaraes, Alexander R., Aleman, Jose O., Luo, Ji, Stephanopoulos, Gregory, Weissleder, Ralph, Cantley, Lewis C., Kahn, C. Ronald

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Identification of CDCP1 as a hypoxia-inducible factor 2  (HIF-2 ) target gene that is associated with survival in clear cell renal cell carcinoma patients by Emerling, B. M., Benes, Cyril H., Poulogiannis, G., Courtney, K., Liu, H., Choo-Wing, R., Bellinger, Gary, Tsukazawa, K. S., Brown, V., Signoretti, S., Soltoff, S. P., Cantley, Lewis C., Bell, Eric L.

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Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells by Vander Heiden, Matthew G., Locasale, Jason W., Swanson, Kenneth D., Sharfi, Hadar, Heffron, Gregory J., Amador-Noguez, Daniel, Christofk, Heather R., Wagner, Gerhard, Rabinowitz, Joshua D., Asara, John M., Cantley, Lewis C.

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Metabolic Pathway Alterations that Support Cell Proliferation by Vander Heiden, Matthew G., Lunt, Sophia Yunkyungkwon, Dayton, Talya Lucia, Fiske, Brian Prescott, Israelsen, William James, Mattaini, Katherine Ruth, Vokes, N. I., Stephanopoulos, G., Cantley, Lewis C., Metallo, Christian M., Locasale, Jason W.

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2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase by Walsh, Martin J., Brimacombe, Kyle R., Veith, Henrike, Bougie, James M., Daniel, Thomas, Leister, William, Cantley, Lewis C., Vander Heiden, Matthew G., Shen, Min, Auld, Douglas S., Thomas, Craig J., Boxer, Matthew B., Israelsen, William James

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Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses by Vander Heiden, Matthew G., Anastasiou, Dimitrios, Poulogiannis, George, Asara, John M., Boxer, Matthew B., Jiang, Jian-kang, Shen, Min, Gary, Bellinger, Sasaki, Atsuo T., Locasale, Jason W., Auld, Douglas S., Thomas, Craig J., Cantley, Lewis C., Bellinger, Gary

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The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 by Csibi, Alfred, Fendt, Sarah-Maria, Li, Chenggang, Poulogiannis, George, Choo, Andrew Y., Chapski, Douglas J., Jeong, Seung Min, Dempsey, Jamie M., Parkhitko, Andrey, Morrison, Tasha, Henske, Elizabeth P., Haigis, Marcia C., Cantley, Lewis C., Stephanopoulos, Gregory, Yu, Jane, Blenis, John

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Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis by Banko, Max R., Allen, Jasmina J., Schaffer, Bethany E., Wilker, Erik W., Tsou, Peiling, White, Jamie L., Villen, Judit, Wang, Beatrice, Kim, Sara R., Sakamoto, Kei, Gygi, Steven P., Cantley, Lewis C., Yaffe, Michael B., Shokat, Kevan M., Brunet, Anne

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Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State by Garcia-Cao, Isabel, Song, Min Sup, Hobbs, Robin M., Laurent, Gaelle, Giorgi, Carlotta, de Boer, Vincent C. J., Anastasiou, Dimitrios, Ito, Keisuke, Sasaki, Atsuo T., Rameh, Lucia, Carracedo, Arkaitz, Vander Heiden, Matthew G., Cantley, Lewis C., Pinton, Paolo, Haigis, Marcia C., Pandolfi, Pier Paolo, Vander Heiden, Matthew G.

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Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism by Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark Andrew, Davidson, Shawn Michael, Wirth, Gregory J., Fiske, Brian Prescott, Mayers, Jared R., Schwab, Matthias, Bellinger, Gary, Csibi, Alfred, Patnaik, Akash, Blouin, Marie Jose, Cantley, Lewis C., Guarente, Leonard Pershing, Blenis, John, Pollak, Michael N., Olumi, Aria F., Vander Heiden, Matthew G., Stephanopoulos, Gregory

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Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival by Yi, Caroline H., Pan, Heling, Seebacher, Jan, Jang, Il-Ho, Hyberts, Sven G., Heffron, Gregory J., Vander Heiden, Matthew G., Yang, Renliang, Li, Fupeng, Locasale, Jason W., Sharfi, Hadar, Zhai, Bo, Rodriguez-Mias, Ricard, Luithardt, Harry, Cantley, Lewis C., Daley, George Q., Asara, John M., Gygi, Steven P., Wagner, Gerhard, Liu, Chuan-Fa, Yuan, Junying

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PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells by Li, Jie, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Israelsen, William James, Dayton, Talya L., Davidson, Shawn M., Fiske, Brian Prescott, Hosios, Aaron Marc, Bellinger, Gary, Yu, Yimin, Jacks, Tyler E., Vander Heiden, Matthew G.

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Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma by Davidson, Shawn M, Schmidt, Daniel R, Heyman, Julia E, O'Brien, James P, Liu, Amy C, Israelsen, William J, Dayton, Talya L, Sehgal, Raghav, Bronson, Roderick T, Freinkman, Elizaveta, Mak, Howard H, Fanelli, Giuseppe Nicolò, Malstrom, Scott, Bellinger, Gary, Carracedo, Arkaitz, Pandolfi, Pier Paolo, Courtney, Kevin D, Jha, Abhishek, DePinho, Ronald A, Horner, James W, Thomas, Craig J, Cantley, Lewis C, Loda, Massimo, Vander Heiden, Matthew G

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis by Locasale, Jason W., Grassian, Alexandra R., Melman, Tamar, Lyssiotis, Costas A., Mattaini, Katherine Ruth, Bass, Adam J., Heffron, Gregory J., Metallo, Christian M., Muranen, Taru, Sharfi, Hadar, Sasaki, Atsuo T., Anastasiou, Dimitrios, Mullarky, Edouard, Vokes, Natalie I., Sasaki, Mika, Beroukhim, Rameen, Stephanopoulos, Gregory, Ligon, Azra H., Meyerson, Matthew L., Richardson, Andrea L., Chin, Lynda, Wagner, Gerhard, Asara, John M., Brugge, Joan S., Cantley, Lewis C., Vander Heiden, Matthew G.

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