Editorial: Pharmacoinformatics: new developments and challenges in drug design by David Ramírez, Rafael Peláez, Rafael Peláez, Rafael Peláez, Carlos F. Lagos, Carlos F. Lagos, José L. Medina-Franco

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Case Report: Concurrent de novo pathogenic variants in the LMNA gene as a cause of sporadic partial lipodystrophy by José L. Santos, José L. Santos, José Patricio Miranda, José Patricio Miranda, Carlos F. Lagos, Carlos F. Lagos, Víctor A. Cortés

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An amphipathic alpha-helix in the prodomain of cocaine and amphetamine regulated transcript peptide precursor serves as its sorting signal to the regulated secretory pathway. by Elías H Blanco, Carlos F Lagos, María Estela Andrés, Katia Gysling

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Molecular Modeling of Structures and Interaction of Human Corticotropin-Releasing Factor (CRF) Binding Protein and CRF Type-2 Receptor by Paula G. Slater, Sebastian E. Gutierrez-Maldonado, Katia Gysling, Carlos F. Lagos

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Novel FXa Inhibitor Identification through Integration of Ligand- and Structure-Based Approaches by Carlos F. Lagos, Gerardine F. Segovia, Nicolás Nuñez-Navarro, Mario A. Faúndez, Flavia C. Zacconi

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Divergent metabolic phenotype between two sisters with congenital generalized lipodystrophy due to double AGPAT2 homozygous mutations. a clinical, genetic and in silico study. by Víctor A Cortés, Susan V Smalley, Denisse Goldenberg, Carlos F Lagos, María I Hodgson, José L Santos

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Innovative Three-Step Microwave-Promoted Synthesis of <i>N</i>-Propargyltetrahydroquinoline and 1,2,3-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design, S... by Fabián Santana-Romo, Carlos F. Lagos, Yorley Duarte, Francisco Castillo, Yanina Moglie, Miguel A. Maestro, Nitin Charbe, Flavia C. Zacconi

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Novel <i>N</i>-Arylsulfonylindoles Targeted as Ligands of the 5-HT₆ Receptor. Insights on the Influence of C-5 Substitution on Ligand Affinity by Loreto Arrieta-Rodríguez, Daniela Espinoza-Rosales, Gonzalo Vera, Young Hwa Cho, David Cabezas, David Vásquez-Velásquez, Jaime Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo

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2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human β3-Adrenergic Activity by Gastón Apablaza, Luisa Montoya, Cesar Morales-Verdejo, Marco Mellado, Mauricio Cuellar, Carlos F. Lagos, Jorge Soto-Delgado, Hery Chung, Carlos David Pessoa-Mahana, Jaime Mella

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Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands by Patricio Iturriaga-Vásquez, Carlos David Pessoa-Mahana, Hernán Pessoa-Mahana, Javier Romero-Parra, Christian Espinosa-Bustos, Carlos F. Lagos, Gonzalo Recabarren-Gajardo, Jaime A. Mella-Raipán

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Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis &amp; Biological Evaluation by Gonzalo Vera, Carlos F. Lagos, Sebastián Almendras, Dan Hebel, Francisco Flores, Gissella Valle-Corvalán, C. David Pessoa-Mahana, Jaime Mella-Raipán, Rodrigo Montecinos, Gonzalo Recabarren-Gajardo

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Novel splice-affecting variants in CYP27A1 gene in two Chilean patients with Cerebrotendinous Xanthomatosis by Susan V. Smalley, Yudith Preiss, José Suazo, Javier Andrés Vega, Isidora Angellotti, Carlos F. Lagos, Enzo Rivera, Karin Kleinsteuber, Javier Campion, J. Alfredo Martínez, Alberto Maiz, José Luis Santos

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Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation by Bruno A. Cisterna, Aníbal A. Vargas, Carlos Puebla, Paola Fernández, Rosalba Escamilla, Carlos F. Lagos, María F. Matus, Cristian Vilos, Luis A. Cea, Esteban Barnafi, Hugo Gaete, Daniel F. Escobar, Christopher P. Cardozo, Juan C. Sáez

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A conserved NR5A1-responsive enhancer regulates SRY in testis-determination by Denis Houzelstein, Caroline Eozenou, Carlos F. Lagos, Maëva Elzaiat, Joelle Bignon-Topalovic, Inma Gonzalez, Vincent Laville, Laurène Schlick, Somboon Wankanit, Prochi Madon, Jyotsna Kirtane, Arundhati Athalye, Federica Buonocore, Stéphanie Bigou, Gerard S. Conway, Delphine Bohl, John C. Achermann, Anu Bashamboo, Ken McElreavey

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Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia by Hugo E. Tobar, Luis R. Cataldo, Trinidad González, Ricardo Rodríguez, Valentina Serrano, Antonio Arteaga, Ana Álvarez-Mercado, Carlos F. Lagos, Lucas Vicuña, José P. Miranda, Ana Pereira, Carolina Bravo, Concepción M. Aguilera, Susana Eyheramendy, Ricardo Uauy, Álvaro Martínez, Ángel Gil, Omar Francone, Attilio Rigotti, José L. Santos

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Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division by Andrea Vecchiola, Andrea Vecchiola, Cristóbal A. Fuentes, Isidora Solar, Carlos F. Lagos, Maria Cecilia Opazo, Maria Cecilia Opazo, Natalia Muñoz-Durango, Natalia Muñoz-Durango, Claudia A. Riedel, Claudia A. Riedel, Gareth I. Owen, Gareth I. Owen, Alexis M. Kalergis, Alexis M. Kalergis, Alexis M. Kalergis, Carlos E. Fardella, Carlos E. Fardella, Carlos E. Fardella

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Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency by Sinéad M. McGlacken-Byrne, Ignacio Del Valle, Polona Le Quesne Stabej, Laura Bellutti, Luz Garcia-Alonso, Louise A. Ocaka, Miho Ishida, Jenifer P. Suntharalingham, Andrey Gagunashvili, Olumide K. Ogunbiyi, Talisa Mistry, Federica Buonocore, GOSgene, Berta Crespo, Nadjeda Moreno, Paola Niola, Tony Brooks, Caroline E. Brain, Mehul T. Dattani, Daniel Kelberman, Roser Vento-Tormo, Carlos F. Lagos, Gabriel Livera, Gerard S. Conway, John C. Achermann

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