Back to the future: the amazing journey of the therapeutic anti-leukemia enzyme asparaginase <i>Erwinia chrysanthemi</i> por Wing H. Tong, Carmelo Rizzari

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A Delphi study to determine the epidemiology and clinical management of patients treated with HDMTX who develop methotrexate (MTX) delayed elimination in France, Germany, Italy, an... por Stefan Bielack, Christopher P. Fox, Khê Hoang‐Xuan, Ariadna Giró‐Perafita, Carmelo Rizzari

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Challenging management of severe differentiation syndrome in pediatric acute promyelocytic leukemia treated with ATRA/ATO por Alessandro Molinaro, Daniela Zanta, Maria Luisa Moleti, Fiorina Giona, Valentino Conter, Carmelo Rizzari, Andrea Biondi, Anna Maria Testi

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Blinatumomab is associated with better post-transplant outcome than chemotherapy in children with high-risk first-relapse B-cell acute lymphoblastic leukemia irrespective of the co... por Christina Peters, Angela Bruno, Carmelo Rizzari, Alessandra Brescianini, Arend von Stackelberg, Christin Linderkamp, Yi Zeng, Gerhard Zugmaier, Franco Locatelli

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A European consensus recommendation on the management of delayed methotrexate elimination: supportive measures, leucovorin rescue and glucarpidase treatment por Stefan S. Bielack, Carole Soussain, Christopher P. Fox, Caroline Houillier, Thais Murciano, Wendy Osborne, Pier Luigi Zinzani, Carmelo Rizzari, Stefan Schwartz

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High EVI1 Expression due to NRIP1/EVI1 Fusion in Therapy-related Acute Myeloid Leukemia: Description of the First Pediatric Case por Mariella D’Angiò, Grazia Fazio, Andrea Grioni, Sonia Palamini, Simona Sala, Marta Galbiati, Andrea Biondi, Adriana Balduzzi, Carmelo Rizzari, Giovanni Cazzaniga

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P406: INCIDENCE OF COMPLICATIONS OF HIGH-DOSE METHOTREXATE ADMINISTRATION IN ADULTS AND CHILDREN WITH HEMATOLOGIC CANCERS: PRELIMINARY RESULTS FROM A EUROPEAN REGISTRY por Scott Howard, Ryan Combs, Jennifer Lowe, Carmelo Rizzari, María Dolores Aumente, Pere Barba Suñol, Thais Murciano, Margarita Satostegui, Claudia Sampor, Nicolás Tentoni

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Rationale for a pediatric-inspired approach in the adolescent and young adult population with acute lymphoblastic leukemia, with a focus on asparaginase treatment por Carmelo Rizzari, Maria Caterina Putti, Antonella Colombini, Sara Casagranda, Giulia Maria Ferrari, Cristina Papayannidis, Ilaria Iacobucci, Maria Chiara Abbenante, Chiara Sartor, Giovanni Martinelli

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The Healthcare Professionals’ and Patient Advocates’ Perspectives on the Care for Children with Cancer in Europe—A Report from the ESCALIER Project por Maria Otth, Marko Ocokoljic, Theodora Armenkova, Irina Ban, Samira Essiaf, Maximilian Hopfgartner, Lejla Kameric, Pamela R. Kearns, Georgia Kokkinou, Carmelo Rizzari, Carina Schneider, Katrin Scheinemann

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Meeting report of the 1st SIOP Europe Course in Paediatric Oncology: Maasmechelen, Belgium, April 6–9, 2022 – The participants’ view and experience por Raphael J. Morscher, Sarah Al-Jilaihawi, Johan Hamrin, Fiona Poyer, Raheel Altaf Raja, Annika V. Rademacher, Anne Blondeel, Samira Essiaf, Pamela Kearns, Carmelo Rizzari, Reineke Schoot, Andishe Attarbaschi

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Minimal residual disease monitored after induction therapy by RQ-PCR can contribute to tailor treatment of patients with t(8;21) RUNX1-RUNX1T1 rearrangement por Martina Pigazzi, Elena Manara, Barbara Buldini, Valzerda Beqiri, Valeria Bisio, Claudia Tregnago, Roberto Rondelli, Riccardo Masetti, Maria Caterina Putti, Franca Fagioli, Carmelo Rizzari, Andrea Pession, Franco Locatelli, Giuseppe Basso

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Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation por Inge M. van der Sluis, Lynda M. Vrooman, Rob Pieters, Andre Baruchel, Gabriele Escherich, Nicholas Goulden, Veerle Mondelaers, Jose Sanchez de Toledo, Carmelo Rizzari, Lewis B. Silverman, James A. Whitlock

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P374: THROMBOTIC EVENTS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA: EXPERIENCE OF ITALIAN AIEOP CENTERS (2009-2017) por Raffaele Mattera, Maria Caterina Putti, Alessandra Biffi, Rosanna Parasole, Valentino Conter, Carmelo Rizzari, Maria Grazia Valsecchi, Daniela Silvestri, Andrea Biondi, Franco Locatelli, Elena Barisone, Concetta Micalizzi, Tommaso Mina, Valentina Kiren

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Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study por Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura B. Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López‐Viñau López, Carmelo Rizzari, Scott C. Howard

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ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells por Federica Portale, Giulia Cricrì, Silvia Bresolin, Monica Lupi, Stefania Gaspari, Daniela Silvestri, Barbara Russo, Noemi Marino, Paolo Ubezio, Fabio Pagni, Patrizia Vergani, Geertruy Te Kronnie, Maria Grazia Valsecchi, Franco Locatelli, Carmelo Rizzari, Andrea Biondi, Erica Dander, Giovanna D’Amico

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Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administe... por Nicolò Peccatori, Marta Coppola, Antonella Colombini, Daniela Silvestri, Nicoletta Bertorello, Valentina Kiren, Fraia Melchionda, Rosamaria Mura, Daniela Onofrillo, Simona Gobbi, Raffaele Mattera, Luciana Vinti, Tommaso Casini, Nicola Santoro, Domenico Sperlì, Carmelita D’Ippolito, Valentino Conter, Andrea Biondi, Carmelo Rizzari

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Incidence and Characteristics of Hypersensitivity Reactions to PEG-asparaginase Observed in 6136 Children With Acute Lymphoblastic Leukemia Enrolled in the AIEOP-BFM ALL 2009 Study... por Carmelo Rizzari, Anja Möricke, Maria Grazia Valsecchi, Valentino Conter, Martin Zimmermann, Daniela Silvestri, Andishe Attarbaschi, Felix Niggli, Draga Barbaric, Jan Stary, Sarah Elitzur, Gunnar Cario, Luciana Vinti, Joachim Boos, Massimo Zucchetti, Claudia Lanvers-Kaminsky, Arend von Stackelberg, Andrea Biondi, Martin Schrappe

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Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated <i>E. coli</i> asparaginase in children with acute lymphocyt... por Alaeddin Khalil, Gudrun Würthwein, Jana Golitsch, Georg Hempel, Manfred Fobker, Joachim Gerss, Anja Möricke, Martin Zimmermann, Petr Smisek, Massimo Zucchetti, Christa Nath, Andishe Attarbaschi, Arend von Stackelberg, Nicola Gökbuget, Carmelo Rizzari, Valentino Conter, Martin Schrappe, Joachim Boos, Claudia Lanvers-Kaminsky

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The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia: results of the international study Relapsed AML 2001/01 por Ursula Creutzig, Martin Zimmermann, Michael N. Dworzak, Brenda Gibson, Rienk Tamminga, Jonas Abrahamsson, Shau-Yin Ha, Henrik Hasle, Alexey Maschan, Yves Bertrand, Guy Leverger, Christine von Neuhoff, Bassem Razzouk, Carmelo Rizzari, Petr Smisek, Owen P. Smith, Batia Stark, Dirk Reinhardt, Gertjan L. Kaspers

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Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia por Janina Heilmann, Simon Vieth, Anja Möricke, Andishe Attarbaschi, Draga Barbaric, Nicole Bodmer, Antonella Colombini, Luciano Dalla-Pozza, Sarah Elitzur, Shai Izraeli, Georg Mann, Felix Niggli, Daniela Silvestri, Jan Stary, Carmelo Rizzari, Maria Grazia Valsecchi, Ester Zapotocka, Martin Zimmermann, Gunnar Cario, Martin Schrappe, Valentino Conter

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