ARDS Subphenotypes: Understanding a Heterogeneous Syndrome by Jennifer G. Wilson, Carolyn S. Calfee

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Subphenotypes of Acute Respiratory Distress Syndrome: Advancing Towards Precision Medicine by Andrea R. Levine, Carolyn S. Calfee

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Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses by Lucile P. A. Neyton, Charles R. Langelier, Carolyn S. Calfee

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A manifesto for the future of ICU trials by Ewan C. Goligher, Fernando Zampieri, Carolyn S. Calfee, Christopher W. Seymour

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Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection by Mazharul Maishan, Aartik Sarma, Aartik Sarma, Lauren F. Chun, Saharai Caldera, Xiaohui Fang, Jason Abbott, Stephanie A. Christenson, Stephanie A. Christenson, Charles R. Langelier, Charles R. Langelier, Carolyn S. Calfee, Carolyn S. Calfee, Carolyn S. Calfee, Carolyn S. Calfee, Jeffrey E. Gotts, Jeffrey E. Gotts, Jeffrey E. Gotts, Michael A. Matthay, Michael A. Matthay, Michael A. Matthay

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Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure by Rajani Ghale, Natasha Spottiswoode, Mark S. Anderson, Anthea Mitchell, Grace Wang, Carolyn S. Calfee, Joseph L. DeRisi, Charles R. Langelier

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Long-term ozone exposure is positively associated with telomere length in critically ill patients by Chunxue Wang, Paul J. Wolters, Carolyn S. Calfee, Shuo Liu, John R. Balmes, Zhiguo Zhao, Tatsuki Koyama, Lorraine B. Ware

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Twenty‐Four‐Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users by Neal L. Benowitz, Gideon St.Helen, Natalie Nardone, Newton Addo, Junfeng (Jim) Zhang, Arit M. Harvanko, Carolyn S. Calfee, Peyton Jacob

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Promises and challenges of personalized medicine to guide ARDS therapy by Katherine D. Wick, Daniel F. McAuley, Joseph E. Levitt, Jeremy R. Beitler, Djillali Annane, Elisabeth D. Riviello, Carolyn S. Calfee, Michael A. Matthay

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Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial by Kimberley M. DeMerle, Jason N. Kennedy, Chung-Chou H. Chang, Kevin Delucchi, David T. Huang, Max S. Kravitz, Nathan I. Shapiro, Donald M. Yealy, Derek C. Angus, Carolyn S. Calfee, Christopher W. Seymour

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The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients by Victoria T. Chu, Alexandra Tsitsiklis, Eran Mick, Lilliam Ambroggio, Katrina L. Kalantar, Abigail Glascock, Christina M. Osborne, Brandie D. Wagner, Michael A. Matthay, Joseph L. DeRisi, Carolyn S. Calfee, Peter M. Mourani, Charles R. Langelier

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Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research by Lieuwe D.J. Bos, Antonio Artigas, Jean-Michel Constantin, Laura A. Hagens, Nanon Heijnen, John G. Laffey, Nuala Meyer, Laurent Papazian, Lara Pisani, Marcus J. Schultz, Manu Shankar-Hari, Marry R. Smit, Charlotte Summers, Lorraine B. Ware, Raffaele Scala, Carolyn S. Calfee

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Hospital trajectories and early predictors of clinical outcomes differ between SARS-CoV-2 and influenza pneumonia by Patrick G. Lyons, Sivasubramanium V. Bhavani, Aaloke Mody, Alice Bewley, Katherine Dittman, Aisling Doyle, Samuel L. Windham, Tej M. Patel, Bharat Neelam Raju, Matthew Keller, Matthew M. Churpek, Carolyn S. Calfee, Andrew P. Michelson, Thomas Kannampallil, Elvin H. Geng, Pratik Sinha

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Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series by Kaia E. Barth, Natasha Spottiswoode, Charlotte Hurabielle, Lakshmi Subbaraj, COMET Consortium, Carolyn S. Calfee, Michael A. Matthay, Sarah French, Andrew Connolly, Stephen M. Hewitt, Kevin M. Vannella, Kevin M. Vannella, Christopher Barnett, Charles R. Langelier, Charles R. Langelier, Sarah Patterson, Sarah Patterson

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Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs by Manu Shankar-Hari, Shalini Santhakumaran, A Toby Prevost, Josie K Ward, Timothy Marshall, Claire Bradley, Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Michael A Matthay, Jonathan Hackett, Cliona McDowell, John G Laffey, Anthony Gordon, Cecilia M O’Kane, Daniel F McAuley

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Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections by Paula Hayakawa Serpa, Xianding Deng, Mazin Abdelghany, Emily Crawford, Katherine Malcolm, Saharai Caldera, Monica Fung, Aaron McGeever, Katrina L. Kalantar, Amy Lyden, Rajani Ghale, Thomas Deiss, Norma Neff, Steven A. Miller, Sarah B. Doernberg, Charles Y. Chiu, Joseph L. DeRisi, Carolyn S. Calfee, Charles R. Langelier

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Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study by Brian J. Anderson, Carolyn S. Calfee, Kathleen D. Liu, John P. Reilly, Kirsten N. Kangelaris, Michael G. S. Shashaty, Aili L. Lazaar, Andrew I. Bayliffe, Robert J. Gallop, Todd A. Miano, Thomas G. Dunn, Erik Johansson, Jason Abbott, Alejandra Jauregui, Thomas Deiss, Kathryn Vessel, Annika Belzer, Hanjing Zhuo, Michael A. Matthay, Nuala J. Meyer, Jason D. Christie

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Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis by Carrie M. Rosenberger, Katherine D. Wick, Hanjing Zhuo, Nelson Wu, Yue Chen, Sharookh B. Kapadia, Alessander Guimaraes, Diana Chang, David F. Choy, Hubert Chen, Melicent Peck, Kathryn M. Sullivan, Serena Ke, Alejandra Jauregui, Aleksandra Leligdowicz, Pratik Sinha, Antonio D. Gomez, Kirsten N. Kangelaris, Kevin Delucchi, Kathleen D. Liu, Carolyn S. Calfee, Michael A. Matthay, Carolyn M. Hendrickson

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Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19 by Katherine D. Wick, Aleksandra Leligdowicz, Andrew Willmore, Sidney A. Carrillo, Rajani Ghale, Alejandra Jauregui, Suzanna S. Chak, Viet Nguyen, Deanna Lee, Chayse Jones, Robin Dewar, H. Clifford Lane, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Kathleen D. Liu, Pratik Sinha, David J. Erle, Charles R. Langelier, Matthew F. Krummell, Prescott G. Woodruff, Carolyn S. Calfee, Michael A. Matthay, the COMET Consortium

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Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses by Eran Mick, Jack Kamm, Angela Oliveira Pisco, Kalani Ratnasiri, Jennifer M. Babik, Gloria Castañeda, Joseph L. DeRisi, Angela M. Detweiler, Samantha L. Hao, Kirsten N. Kangelaris, G. Renuka Kumar, Lucy M. Li, Sabrina A. Mann, Norma Neff, Priya A. Prasad, Paula Hayakawa Serpa, Sachin J. Shah, Natasha Spottiswoode, Michelle Tan, Carolyn S. Calfee, Stephanie A. Christenson, Amy Kistler, Charles Langelier

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