ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability by Spear, ED, Hsu, E-T, Nie, L, Carpenter, EP, Hrycyna, CA, Michaelis, S

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate by Proks, P, Schewe, M, Conrad, LJ, Rao, S, Rathje, K, Rödström, KEJ, Carpenter, EP, Baukrowitz, T, Tucker, SJ

The structural basis of fatty acid elongation by the ELOVL elongases by Nie, L, Pascoa, TC, Pike, ACW, Bushell, SR, Quigley, A, Ruda, GF, Chu, A, Cole, V, Speedman, D, Moreira, T, Shrestha, L, Mukhopadhyay, SMM, Burgess-Brown, NA, Love, JD, Brennan, PE, Carpenter, EP

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation by Rödström, KEJ, Cloake, A, Sörmann, J, Baronina, A, Smith, KHM, Pike, ACW, Ang, J, Proks, P, Schewe, M, Holland-Kaye, I, Bushell, SR, Elliott, J, Pardon, E, Baukrowitz, T, Owens, RJ, Newstead, S, Steyaert, J, Carpenter, EP, Tucker, SJ

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2 by Li, HZ, Pike, ACW, Lotsaris, I, Chi, G, Hansen, JS, Lee, SC, Rödström, KEJ, Bushell, SR, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Burgess-Brown, NA, Vandenberg, RJ, Dafforn, TR, Carpenter, EP, Sauer, DB

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K by Bushell, SR, Pike, ACW, Falzone, ME, Rorsman, NJG, Ta, CM, Corey, RA, Newport, TD, Christianson, JC, Scofano, LF, Shintre, CA, Tessitore, A, Chu, A, Wang, Q, Shrestha, L, Mukhopadhyay, SMM, Love, JD, Burgess-Brown, NA, Sitsapesan, R, Stansfeld, PJ, Huiskonen, JT, Tammaro, P, Accardi, A, Carpenter, EP

Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea by Sörmann, J, Schewe, M, Proks, P, Jouen-Tachoire, T, Rao, S, Riel, EB, Agre, KE, Begtrup, A, Dean, J, Descartes, M, Fischer, J, Gardham, A, Lahner, C, Mark, PR, Muppidi, S, Pichurin, PN, Porrmann, J, Schallner, J, Smith, K, Straub, V, Vasudevan, P, Willaert, R, Carpenter, EP, Rödström, KEJ, Hahn, MG, Müller, T, Baukrowitz, T, Hurles, ME, Wright, CF, Tucker, SJ

Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design by Dong, YY, Wang, H, Pike, ACW, Cochrane, SA, Hamedzadeh, S, Wyszyński, FJ, Bushell, SR, Royer, SF, Widdick, DA, Sajid, A, Boshoff, HI, Park, Y, Lucas, R, Liu, W-M, Lee, SS, Machida, T, Minall, L, Mehmood, S, Belaya, K, Liu, W-W, Chu, A, Shrestha, L, Mukhopadhyay, SMM, Strain-Damerell, C, Chalk, R, Burgess-Brown, NA, Bibb, MJ, Barry, CE, Robinson, CV, Beeson, D, Davis, BG, Carpenter, EP