Book Review: Transplantation of Neural Tissue into the Spinal Cord by Caryl E. Sortwell Ph.D.

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Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity by Anna C. Stoll, Caryl E. Sortwell

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Synucleinopathy-associated pathogenesis in Parkinson’s disease and the potential for brain-derived neurotrophic factor by Kathryn M. Miller, Natosha M. Mercado, Caryl E. Sortwell

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Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease by Megan F. Duffy, Timothy J. Collier, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, D. Luke Fischer, Anna C. Stoll, Caryl E. Sortwell, Caryl E. Sortwell

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Reassessment of Caspase Inhibition to Augment Grafted Dopamine Neuron Survival by Deanna M. Marchionini, Timothy J. Collier, Mark R. Pitzer, Caryl E. Sortwell

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BDNF rs10501087, rs1491850 and rs11030094 polymorphisms associated with delayed progression in early-stage Parkinson's disease by D. Luke Fischer, Peggy Auinger, John L. Goudreau, Katrina L. Paumier, Allyson Cole-Strauss, Christopher J. Kemp, Jack W. Lipton, Jack W. Lipton, Caryl E. Sortwell, Caryl E. Sortwell

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Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats by Eleonora Maries, Jeffrey H. Kordower, Yaping Chu, Timothy J. Collier, Caryl E. Sortwell, Eliza Olaru, Kathleen Shannon, Kathy Steece-Collier

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Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats by Natosha M. Mercado, Carlye Szarowicz, Jennifer A. Stancati, Caryl E. Sortwell, Samuel A. Boezwinkle, Timothy J. Collier, Margaret E. Caulfield, Kathy Steece-Collier

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Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition by Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan Kuhn, Matthew Benskey, Megan F. Duffy, Kelvin C. Luk, Caryl E. Sortwell

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Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions by Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Jacob W. Howe, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell, Matthew J. Benskey

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Downregulation of striatal CaV1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age by Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, Timothy J. Collier, Caryl E. Sortwell, Ivette M. Sandoval, Fredric P. Manfredsson, Kathy Steece-Collier

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Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration by Timothy J. Collier, Jennifer O'Malley, David J. Rademacher, Jennifer A. Stancati, Kellie A. Sisson, Caryl E. Sortwell, Katrina L. Paumier, Kibrom G. Gebremedhin, Kathy Steece-Collier

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High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine. by D Luke Fischer, Timothy J Collier, Allyson Cole-Strauss, Susan L Wohlgenant, Jack W Lipton, Kathy Steece-Collier, Fredric P Manfredsson, Christopher J Kemp, Caryl E Sortwell

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Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS by Nicholas M. Kanaan, Rhyomi C. Sellnow, Sanford L. Boye, Ben Coberly, Antonette Bennett, Mavis Agbandje-McKenna, Caryl E. Sortwell, William W. Hauswirth, Shannon E. Boye, Fredric P. Manfredsson

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The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats by Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier

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Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits by Aysegul O. Gezer, Joseph Kochmanski, Sarah E. VanOeveren, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson, Kathryn M. Miller, Nathan C. Kuhn, Danielle E. Herman, Alyssa McIntire, Jack W. Lipton, Kelvin C. Luk, Sheila M. Fleming, Caryl E. Sortwell, Alison I. Bernstein

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Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form by Timothy J. Collier, Kinshuk R. Srivastava, Craig Justman, Tom Grammatopoulous, Birgit Hutter-Paier, Manuela Prokesch, Daniel Havas, Jean-Christophe Rochet, Fang Liu, Kevin Jock, Patrícia de Oliveira, Georgia L. Stirtz, Ulf Dettmer, Caryl E. Sortwell, Mel B. Feany, Peter Lansbury, Lisa Lapidus, Katrina L. Paumier

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Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities by Erin K. Purcell, Michael F. Becker, Yue Guo, Seth A. Hara, Kip A. Ludwig, Collin J. McKinney, Elizabeth M. Monroe, Robert Rechenberg, Cory A. Rusinek, Akash Saxena, James R. Siegenthaler, Caryl E. Sortwell, Cort H. Thompson, James K. Trevathan, Suzanne Witt, Wen Li

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Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration by Katrina L. Paumier, Kelvin C. Luk, Fredric P. Manfredsson, Nicholas M. Kanaan, Jack W. Lipton, Timothy J. Collier, Kathy Steece-Collier, Christopher J. Kemp, Stephanie Celano, Emily Schulz, Ivette M. Sandoval, Sheila Fleming, Elliott Dirr, Nicole K. Polinski, John Q. Trojanowski, Virginia M. Lee, Caryl E. Sortwell

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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed... by Joseph R. Patterson, Megan F. Duffy, Christopher J. Kemp, Jacob W. Howe, Timothy J. Collier, Anna C. Stoll, Kathryn M. Miller, Pooja Patel, Nathan Levine, Darren J. Moore, Kelvin C. Luk, Sheila M. Fleming, Nicholas M. Kanaan, Katrina L. Paumier, Omar M.A. El-Agnaf, Caryl E. Sortwell

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