Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase. by Champness, J, Stammers, D, Beddell, C

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution. by Champness, J, Achari, A, Ballantine, S, Bryant, P, Delves, C, Stammers, D

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution. by Champness, J, Achari, A, Ballantine, S, Bryant, P, Delves, C, Stammers, D

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. by Achari, A, Somers, DO, Champness, J, Bryant, P, Rosemond, J, Stammers, D

Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim. by Kuyper, L, Garvey, J, Baccanari, D, Champness, J, Stammers, D, Beddell, C

2.0 A X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue. by Stammers, D, Achari, A, Somers, DO, Bryant, P, Rosemond, J, Scott, D, Champness, J

The binding of trimethoprim to bacterial dihydrofolate reductase. by Baker, D, Beddell, C, Champness, J, Goodford, P, Norrington, F, Smith, DR, Stammers, D

Preliminary crystallographic data for Pneumocystis carinii dihydrofolate reductase. by Stammers, D, Delves, C, Ballantine, S, Jones, E, Stuart, D, Achari, A, Bryant, P, Champness, J

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme. by Stammers, D, Champness, J, Beddell, C, Dann, J, Eliopoulos, E, Geddes, A, Ogg, D, North, A

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted tr... by Kuyper, L, Roth, B, Baccanari, D, Ferone, R, Beddell, C, Champness, J, Stammers, D, Dann, J, Norrington, F, Baker, D

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim. by Matthews, D, Bolin, J, Burridge, J, Filman, D, Volz, K, Kaufman, B, Beddell, C, Champness, J, Stammers, D, Kraut, J

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted tr... by Kuyper, L, Roth, B, Baccanari, D, Ferone, R, Beddell, C, Champness, J, Stammers, D, Dann, J, Norrington, F, Baker, D, Goodford, P