Charles Brenton Huggins
Charles Brenton Huggins (September 22, 1901 – January 12, 1997) was a Canadian-American surgeon and physiologist known for his work on
prostate function,
prostate cancer, and
breast cancer. Born in
Halifax in 1901, Huggins moved to the United States for medical school. He was one of the founding staff members of the
University of Chicago Medical School, where he remained for the duration of his professional research career. Huggins' work on how
sex hormones influence prostate function ultimately led to his discovery of hormone therapies to treat prostate cancer. For this finding, he was awarded the 1966
Nobel Prize for Physiology or Medicine. In addition to his work on prostate cancer, Huggins explored the relationship between hormones and breast cancer, developed an
animal model for breast cancer, and developed "chromogenic substrate"s that are widely used for biochemical analyses. Huggins continued to perform research into his 90s; he died in
Chicago in 1997.
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