Large scale meta-analysis identifies new genetic risk loci for esophageal adenocarcinoma (EA) and the first EA risk locus independent of Barrett’s esophagus od Palles, C, Tomlinson, I, Chegwidden, L, Gharahkhani, P, MacGregor, S, Vaughan, T, Schumacher, J, Jankowski, J, Fitzgerald, R, Gockel, I, Buas, M, Knapp, M, Noethen, M, Becker, J, Pharaoh, P, Whiteman, D

The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression. od Thomas, R, Trapani, D, Goodyer-Sait, L, Tomkova, M, Fernandez-Rozadilla, C, Sahnane, N, Woolley, C, Davis, H, Chegwidden, L, Kriaucionis, S, Maughan, T, Leedham, S, Palles, C, Furlan, D, Tomlinson, I, Lewis, A

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden... od Temko, D, Van Gool, IC, Rayner, E, Glaire, M, Makino, S, Brown, MW, Chegwidden, L, Palles, C, Depreeuw, J, Beggs, A, Stathopoulou, C, Mason, J, Baker, A-M, Williams, M, Cerundolo, E, Rei, M, Taylor, J, Schuh, A, Ahmed, A, Amant, F, Lambrechts, D, Smit, VTHBM, Bosse, T, Graham, TA, Church, DN, Tomlinson, I

The evolutionary landscape of colorectal tumorigenesis od Cross, W, Kovac, M, Mustonen, V, Temko, D, Davis, H, Baker, A, Biswas, S, Arnold, R, Chegwidden, L, Gatenbee, C, Anderson, A, Koelzer, V, Martinez, P, Jiang, X, Domingo, E, Woodcock, D, Feng, Y, Kovacova, M, Maughan, T, S:Cort Consortium, Jansen, M, Rodriguez-Justo, M, Ashraf, S, Guy, R, Cunningham, C, East, J, Wedge, D, Wang, L, Palles, C, Heinimann, K, Sottoriva, A, Leedham, S, Graham, T, Tomlinson, I

Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma od Buas, M, He, Q, Johnson, L, Onstad, L, Levine, D, Thrift, A, Gharahkhani, P, Palles, C, Lagergren, J, Fitzgerald, R, Ye, W, Caldas, C, Bird, N, Shaheen, N, Bernstein, L, Gammon, M, Wu, A, Hardie, L, Pharoah, P, Liu, G, Iyer, P, Corley, D, Risch, H, Chow, W, Prenen, H, Chegwidden, L, Love, S, Attwood, S, Moayyedi, P, MacDonald, D, Harrison, R, Watson, P, Barr, H, deCaestecker, J, Tomlinson, I, Jankowski, J, Whiteman, D, MacGregor, S, Vaughan, T, Madeleine, M

Germline genetic variants and risk of Barrett's esophagus and esophageal adenocarcinoma: a large scale meta-analysis of genome-wide association studies od Palles, C, Tomlinson, I, Chegwidden, L, Gharahkhani, P, MacGregor, S, Vaughan, T, Schumacher, J, Jankowski, J, Fitzgerald, R, Gockel, I, Buas, M, May, A, Gerges, C, Anders, M, Becker, J, Kreuser, N, Noder, T, Venerito, M, Veits, L, Schmidt, T, Manner, H, Schmidt, C, Hess, T, Böhmer, A, Izbicki, J, Hölscher, A, Lang, H, Lorenz, D, Schumacher, B, Hackelsberger, A, Mayershofer, R, Pech, O, Vashist, Y, Ott, K, Vieth, M, Weismüller, J, Nöthen, M, Attwood, S, Barr, H, de Caestecker, J, Harrison, R, Love, S, MacDonald, D, Moayyed, P, Prenen, H, Watson, R, Iyer, P, Anderson, L, Bernstein, L, Chow, W, Hardie, L, Lagergren, J, Liu, G, Risch, H, Wu, A, Ye, W, Bird, N, Shaheen, N, Gammon, M, Corley, D, Caldas, C, Moebus, S, Knapp, M, Peters, W, Neuhaus, H, Rösch, T, Ell, C, Pharaoh, P, Whiteman, D

Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis. od Gharahkhani, P, Fitzgerald, R, Vaughan, T, Palles, C, Gockel, I, Tomlinson, I, Buas, M, May, A, Gerges, C, Anders, M, Becker, J, Kreuser, N, Noder, T, Venerito, M, Veits, L, Schmidt, T, Manner, H, Schmidt, C, Hess, T, Böhmer, A, Izbicki, J, Hölscher, A, Lang, H, Lorenz, D, Schumacher, B, Hackelsberger, A, Mayershofer, R, Pech, O, Vashist, Y, Ott, K, Vieth, M, Weismüller, J, Nöthen, M, Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), Esophageal Adenocarcinoma GenEtics Consortium (EAGLE), Wellcome Trust Case Control Consortium 2 (WTCCC2), Attwood, S, Barr, H, Chegwidden, L, de Caestecker, J, Harrison, R, Love, S, MacDonald, D, Moayyedi, P, Prenen, H, Watson, R, Iyer, P, Anderson, L, Bernstein, L, Chow, W, Hardie, L, Lagergren, J, Liu, G, Risch, H, Wu, A, Ye, W, Bird, N, Shaheen, N, Gammon, M, Corley, D, Caldas, C, Moebus, S, Knapp, M, Peters, W, Neuhaus, H, Rösch, T, Ell, C, MacGregor, S, Pharoah, P, Whiteman, D, Jankowski, J, Schumacher, J