Chester Mathis

Chester Mathis is an American chemist who is currently the Distinguished Professor of Radiology at University of Pittsburgh and holds the UPMC Endowed Chair of PET Research.

He is known for is work with William E. Klunk on a PET radiotracer for imaging amyloid, a protein linked to neurodegenerative diseases including Alzheimer’s. His efforts led to the creation of a novel category of high-efficacy radiopharmaceutical agents, for example Pittsburgh Compound-B (PiB), which can be used to assess beta-amyloid in the living human brain using PET scanning, and which is a fluorescent analog of thioflavin T. For his work on Alzheimer's disease he has received the Metlife Foundation Award (2004) and the Potamkin Prize (2008). Provided by Wikipedia
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  1. 1
    [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.

    [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels. by W Gordon Frankle, Raymond Y Cho, N Scott Mason, Chi-Min Chen, Michael Himes, Christopher Walker, David A Lewis, Chester A Mathis, Rajesh Narendran

    Published 2012-01-01
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  2. 2
    Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects

    Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects by James M. Mountz, Charles M. Laymon, Ann D. Cohen, Zheng Zhang, Julie C. Price, Sanaa Boudhar, Eric McDade, Howard J. Aizenstein, William E. Klunk, Chester A. Mathis

    Published 2015-01-01
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  3. 3
    Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline

    Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline by Akiko Mizuno, Helmet Talib Karim, Helmet Talib Karim, Maria J. Ly, Maria J. Ly, Brian J. Lopresti, Ann D. Cohen, Areej A. Ali, Chester A. Mathis, William E. Klunk, Howard J. Aizenstein, Howard J. Aizenstein, Beth E. Snitz

    Published 2023-09-01
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  4. 4
    PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome

    PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome by Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian

    Published 2021-03-01
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  5. 5
    Comparing Pathological Risk Factors for Dementia between Cognitively Normal Japanese and Americans

    Comparing Pathological Risk Factors for Dementia between Cognitively Normal Japanese and Americans by Chendi Cui, Aya Higashiyama, Brian J. Lopresti, Masafumi Ihara, Howard J. Aizenstein, Makoto Watanabe, Yuefang Chang, Chikage Kakuta, Zheming Yu, Chester A. Mathis, Yoshihiro Kokubo, Tetsuya Fukuda, Victor L. Villemagne, William E. Klunk, Oscar L. Lopez, Lewis H. Kuller, Yoshihiro Miyamoto, Akira Sekikawa

    Published 2021-09-01
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  6. 6
    Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome

    Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome by Matthew D. Zammit, Dana L. Tudorascu, Charles M. Laymon, Sigan L. Hartley, Paul A. Ellison, Shahid H. Zaman, Beau M. Ances, Sterling C. Johnson, Charles K. Stone, Marwan N. Sabbagh, Chester A. Mathis, William E. Klunk, Ann D. Cohen, Benjamin L. Handen, Bradley T. Christian

    Published 2021-01-01
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