DeMAG predicts the effects of variants in clinically actionable genes by integrating structural and evolutionary epistatic features de réir Federica Luppino, Ivan A. Adzhubei, Christopher A. Cassa, Agnes Toth-Petroczy

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Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck. de réir Daniel J Balick, Ron Do, Christopher A Cassa, David Reich, Shamil R Sunyaev

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Machine learning based CRISPR gRNA design for therapeutic exon skipping. de réir Wilson Louie, Max W Shen, Zakir Tahiry, Sophia Zhang, Daniel Worstell, Christopher A Cassa, Richard I Sherwood, David K Gifford

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The missing link between genetic association and regulatory function de réir Noah J Connally, Sumaiya Nazeen, Daniel Lee, Huwenbo Shi, John Stamatoyannopoulos, Sung Chun, Chris Cotsapas, Christopher A Cassa, Shamil R Sunyaev

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Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions de réir Akl C. Fahed, Minxian Wang, Julian R. Homburger, Aniruddh P. Patel, Alexander G. Bick, Cynthia L. Neben, Carmen Lai, Deanna Brockman, Anthony Philippakis, Patrick T. Ellinor, Christopher A. Cassa, Matthew Lebo, Kenney Ng, Eric S. Lander, Alicia Y. Zhou, Sekar Kathiresan, Amit V. Khera

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