Potentiation of thrombin generation in hemophilia A plasma by coagulation factor VIII and characterization of antibody-specific inhibition. by Bhavya S Doshi, Bagirath Gangadharan, Christopher B Doering, Shannon L Meeks

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The Immune Response to the fVIII Gene Therapy in Preclinical Models by Seema R. Patel, Taran S. Lundgren, Taran S. Lundgren, H. Trent Spencer, Christopher B. Doering

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Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A by Harrison C. Brown, Philip M. Zakas, Stephan N. George, Ernest T. Parker, H. Trent Spencer, Christopher B. Doering

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Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells by Lauren C. Fleischer, Scott A. Becker, Rebecca E. Ryan, Andrew Fedanov, Christopher B. Doering, H. Trent Spencer

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Development and characterization of recombinant ovine coagulation factor VIII. by Philip M Zakas, Bagirath Gangadharan, Graca Almeida-Porada, Christopher D Porada, H Trent Spencer, Christopher B Doering

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Genetic engineering of chimeric antigen receptors using lamprey derived variable lymphocyte receptors by Robert Moot, Sunil S Raikar, Lauren Fleischer, Melissa Querrey, Daniel E Tylawsky, Hirotomo Nakahara, Christopher B Doering, H Trent Spencer

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Ex vivo expanded patient-derived γδ T-cell immunotherapy enhances neuroblastoma tumor regression in a murine model by Jaquelyn T. Zoine, Kristopher A. Knight, Lauren C. Fleischer, Kathryn S. Sutton, Kelly C. Goldsmith, Christopher B. Doering, H. Trent Spencer

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Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery by Harrison C Brown, J Fraser Wright, Shangzhen Zhou, Allison M Lytle, Jordan E Shields, H Trent Spencer, Christopher B Doering

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Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines by Sunil S. Raikar, Lauren C. Fleischer, Robert Moot, Andrew Fedanov, Na Yoon Paik, Kristopher A. Knight, Christopher B. Doering, H. Trent Spencer

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Effects of FVIII immunity on hepatocyte and hematopoietic stem cell–directed gene therapy of murine hemophilia A by Allison M Lytle, Harrison C Brown, Na Yoon Paik, Kristopher A Knight, J Fraser Wright, H Trent Spencer, Christopher B Doering

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Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers by Scott A. Becker, Brian G. Petrich, Bing Yu, Kristopher A. Knight, Harrison C. Brown, Sunil S. Raikar, Christopher B. Doering, H. Trent Spencer

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Dissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials by Hunter C. Jonus, Rebecca E. Burnham, Andrew Ho, Adeiye A. Pilgrim, Jenny Shim, Christopher B. Doering, H. Trent Spencer, Kelly C. Goldsmith

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Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII by Athena L. Russell, Chengyu Prince, Taran S. Lundgren, Kristopher A. Knight, Gabriela Denning, Jordan S. Alexander, Jaquelyn T. Zoine, H. Trent Spencer, Shanmuganathan Chandrakasan, Christopher B. Doering

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Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor by Estelle K. Ronayne, Shaun C. Peters, Joseph S. Gish, Celena Wilson, H. Trent Spencer, Christopher B. Doering, Pete Lollar, P. Clint Spiegel, Kenneth C. Childers

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Ligand-based targeting of c-kit using engineered γδ T cells as a strategy for treating acute myeloid leukemia by Gianna M. Branella, Gianna M. Branella, Gianna M. Branella, Jasmine Y. Lee, Jasmine Y. Lee, Jasmine Y. Lee, Jennifer Okalova, Jennifer Okalova, Jennifer Okalova, Kiran K. Parwani, Kiran K. Parwani, Kiran K. Parwani, Jordan S. Alexander, Jordan S. Alexander, Raquel F. Arthuzo, Raquel F. Arthuzo, Raquel F. Arthuzo, Andrew Fedanov, Andrew Fedanov, Bing Yu, David McCarty, Harrison C. Brown, Shanmuganathan Chandrakasan, Shanmuganathan Chandrakasan, Brian G. Petrich, Christopher B. Doering, Christopher B. Doering, Christopher B. Doering, H. Trent Spencer, H. Trent Spencer, H. Trent Spencer

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Investigating Optimal Autologous Cellular Platforms for Prenatal or Perinatal Factor VIII Delivery to Treat Hemophilia A by Christopher Stem, Christopher Rodman, Ritu M. Ramamurthy, Sunil George, Diane Meares, Andrew Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada

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Comparison of different gene addition strategies to modify placental derived-mesenchymal stromal cells to produce FVIII by Ritu M. Ramamurthy, Martin Rodriguez, Hannah C. Ainsworth, Jordan Shields, Diane Meares, Colin Bishop, Andrew Farland, Carl D. Langefeld, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada

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Defining the Optimal FVIII Transgene for Placental Cell-Based Gene Therapy to Treat Hemophilia A by Nadia El-Akabawy, Martin Rodriguez, Ritu Ramamurthy, Andrew Rabah, Brady Trevisan, Alshaimaa Morsi, Sunil George, Jordan Shields, Diane Meares, Andrew Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada

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Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy by Rebecca E. Burnham, Rebecca E. Burnham, Jaquelyn T. Zoine, Jaquelyn T. Zoine, Jamie Y. Story, Jamie Y. Story, Swetha N. Garimalla, Greg Gibson, Aaron Rae, Erich Williams, Lisa Bixby, David Archer, Christopher B. Doering, H. Trent Spencer

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Neutralizing Antibodies Against Factor VIII Can Occur Through a Non-Germinal Center Pathway by Seema R. Patel, Taran S. Lundgren, Taran S. Lundgren, Wallace Hunter Baldwin, Courtney Cox, Ernest T. Parker, John F. Healey, Ryan P. Jajosky, Patricia E. Zerra, Patricia E. Zerra, Cassandra D. Josephson, Christopher B. Doering, Sean R. Stowell, Shannon L. Meeks

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