Does pain optimisation impact delirium outcomes in critically ill patients? A systematic review and meta-analysis protocol by Lisa Burry, Kirsten M. Fiest, Daniel J. Niven, Amanda Y. Leong, Christopher J. Doig

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Delirium diagnosis without a gold standard: Evaluating diagnostic accuracy of combined delirium assessment tools by Stephana J. Moss, Chel Hee Lee, Christopher J. Doig, Liam Whalen-Browne, Henry T. Stelfox, Kirsten M. Fiest

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Delirium diagnosis without a gold standard: Evaluating diagnostic accuracy of combined delirium assessment tools. by Stephana J Moss, Chel Hee Lee, Christopher J Doig, Liam Whalen-Browne, Henry T Stelfox, Kirsten M Fiest

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Describing organ dysfunction in the intensive care unit: a cohort study of 20,000 patients by Andrea Soo, Danny J. Zuege, Gordon H. Fick, Daniel J. Niven, Luc R. Berthiaume, Henry T. Stelfox, Christopher J. Doig

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Perspectives from designated family caregivers of critically ill adult patients during the COVID-19 pandemic: A qualitative interview study. by Stephana J Moss, Karla D Krewulak, Henry T Stelfox, Scott B Patten, Christopher J Doig, Jeanna Parsons Leigh, Kirsten M Fiest

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Perspectives from designated family caregivers of critically ill adult patients during the COVID-19 pandemic: A qualitative interview study by Stephana J. Moss, Karla D. Krewulak, Henry T. Stelfox, Scott B. Patten, Christopher J. Doig, Jeanna Parsons Leigh, Kirsten M. Fiest

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Engaging the Public to Identify Opportunities to Improve Critical Care: A Qualitative Analysis of an Open Community Forum. by Melissa L Potestio, Jamie M Boyd, Sean M Bagshaw, Daren Heyland, Peter Oxland, Christopher J Doig, Dave Zygun, Henry T Stelfox

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The prognostic value of serum procalcitonin measurements in critically injured patients: a systematic review by Aziza N. AlRawahi, Fatma A. AlHinai, Christopher J. Doig, Chad G. Ball, Elijah Dixon, Zhengwen Xiao, Andrew W. Kirkpatrick

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Outcomes of selective nonoperative management of civilian abdominal gunshot wounds: a systematic review and meta-analysis by Aziza N. Al Rawahi, Fatma A. Al Hinai, Jamie M. Boyd, Christopher J. Doig, Chad G. Ball, George C. Velmahos, Andrew W. Kirkpatrick, Pradeep H. Navsaria, Derek J. Roberts

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Community paramedic point of care testing: validity and usability of two commercially available devices by Ian E. Blanchard, Ryan Kozicky, Dana Dalgarno, Justin Simms, Stacy Goulder, Tyler S. Williamson, Susan Biesbroek, Lenore Page, Karen Leaman, Suzanne Snozyk, Lyle Redman, Keith Spackman, Christopher J. Doig, Eddy S. Lang, Gerald Lazarenko

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Stakeholder Engagement to Identify Priorities for Improving the Quality and Value of Critical Care. by Henry T Stelfox, Daniel J Niven, Fiona M Clement, Sean M Bagshaw, Deborah J Cook, Emily McKenzie, Melissa L Potestio, Christopher J Doig, Barbara O'Neill, David Zygun, Critical Care Strategic Clinical Network, Alberta Health Services

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Development and Content Validation of a Multidisciplinary Standardized Management Pathway for Hypoxemic Respiratory Failure and Acute Respiratory Distress Syndrome by Ken Kuljit S. Parhar, MD, MSc, Karolina Zjadewicz, MN, Gwen E. Knight, BA, Andrea Soo, PhD, Jamie M. Boyd, MSc, Danny J. Zuege, MD, MSc, Daniel J. Niven, MD, MSc, PhD, Christopher J. Doig, MD, MSc, Henry T. Stelfox, MD, PhD

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Antimicrobial stewardship, procalcitonin testing, and rapid blood-culture identification to optimize sepsis care in critically ill adult patients: A quality improvement initiative by Wendy I. Sligl, Justin Z. Chen, Xiaoming Wang, Cheyanne Boehm, Karen Fong, Katelynn Crick, Míriam Garrido Clua, Cassidy Codan, Tanis C. Dingle, Daniel Gregson, Connie Prosser, Hossein Sadrzadeh, Charles Yan, Guanmin Chen, Alena Tse-Chang, Daniel Garros, Christopher J. Doig, David Zygun, Dawn Opgenorth, John M. Conly, Sean M Bagshaw

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Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant h... by Alexander Zarbock, Pierre-François Laterre, Peter Pickkers, Rinaldo Bellomo, Paul Young, Derek C Angus, Kent Doi, Michael Joannidis, Marlies Ostermann, Morten Bestle, Ravindra L Mehta, Patrick T Murray, John A Kellum, Jacques Arend, Christopher J Doig, Ville Pettilä, Bruno Francois, Erik van den Berg, Juliane Bernholz, Kristine Broglio, Jan Carlsen, Ricard Ferrer, Kathleen Liu, Sharon Richards, Anne Louise Kjølbye

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Correction to: Ethical considerations in conducting surgical research in severe complicated intra-abdominal sepsis by Christopher J. Doig, Stacey A. Page, Jessica L. McKee, Ernest E. Moore, Fikri M. Abu-Zidan, Rosemary Carroll, John C. Marshall, Peter D. Faris, Matti Tolonen, Fausto Catena, Federico Coccolini, Massimo Sartelli, Luca Ansaloni, Sam F. Minor, Bruno M. Peirera, Jose J. Diaz, Andrew W. Kirkpatrick, Closed Or Open after Laparotomy (COOL) after Source Control for Severe Complicated Intra-Abdominal Sepsis Investigators

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Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial by Andrew W. Kirkpatrick, Federico Coccolini, Luca Ansaloni, Derek J. Roberts, Matti Tolonen, Jessica L. McKee, Ari Leppaniemi, Peter Faris, Christopher J. Doig, Fausto Catena, Timothy Fabian, Craig N. Jenne, Osvaldo Chiara, Paul Kubes, Braden Manns, Yoram Kluger, Gustavo P. Fraga, Bruno M. Pereira, Jose J. Diaz, Michael Sugrue, Ernest E. Moore, Jianan Ren, Chad G. Ball, Raul Coimbra, Zsolt J. Balogh, Fikri M. Abu-Zidan, Elijah Dixon, Walter Biffl, Anthony MacLean, Ian Ball, John Drover, Paul B. McBeth, Juan G. Posadas-Calleja, Neil G. Parry, Salomone Di Saverio, Carlos A. Ordonez, Jimmy Xiao, Massimo Sartelli, for The Closed Or Open after Laparotomy (COOL) after Source Control for Severe Complicated Intra-Abdominal Sepsis Investigators

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A Modified Delphi Process to Prioritize Experiences and Guidance Related to ICU Restricted Visitation Policies During the Coronavirus Disease 2019 Pandemic by Kirsten M. Fiest, PhD, Karla D. Krewulak, PhD, Kira Makuk, BHSc, Natalia Jaworska, MD, MSc, Laura Hernández, BA, Sean M. Bagshaw, MD, MSc, Karen E. Burns, MD, MSc, Deborah J. Cook, MD, MSc, Christopher J. Doig, MD, MSc, Alison Fox-Robichaud, MD, MSc, Robert A. Fowler, MD, MSc, Michelle E. Kho, PT, PhD, Ken Kuljit S. Parhar, MD, MSc, Oleksa G. Rewa, MD, MSc, Bram Rochwerg, MD, MSc, Bonnie G. Sept, Andrea Soo, PhD, Sean Spence, MD, Andrew West, EdD, Henry T. Stelfox, MD, PhD, Jeanna Parsons Leigh, PhD, for the Canadian Critical Care Trials Group, Kusum Menon, Vazquez Grande, Mark Duffet, Jennifer Foster, Dominique Piquette, Nicole Zytaruk, Sylvie Debigaré, Srinivas Murthy, Danaë Tassy, Sangeeta Mehta

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The unrestricted global effort to complete the COOL trial by Andrew W. Kirkpatrick, Federico Coccolini, Matti Tolonen, Samuel Minor, Fausto Catena, Emanuel Gois, Christopher J. Doig, Michael D. Hill, Luca Ansaloni, Massimo Chiarugi, Dario Tartaglia, Orestis Ioannidis, Michael Sugrue, Elif Colak, S. Morad Hameed, Hanna Lampela, Vanni Agnoletti, Jessica L. McKee, Naisan Garraway, Massimo Sartelli, Chad G. Ball, Neil G. Parry, Kelly Voght, Lisa Julien, Jenna Kroeker, Derek J. Roberts, Peter Faris, Corina Tiruta, Ernest E. Moore, Lee Anne Ammons, Elissavet Anestiadou, Cino Bendinelli, Konstantinos Bouliaris, Rosemarry Carroll, Marco Ceresoli, Francesco Favi, Angela Gurrado, Joao Rezende-Neto, Arda Isik, Camilla Cremonini, Silivia Strambi, Georgios Koukoulis, Mario Testini, Sandy Trpcic, Alessandro Pasculli, Erika Picariello, Fikri Abu-Zidan, Ademola Adeyeye, Goran Augustin, Felipe Alconchel, Yuksel Altinel, Luz Adriana Hernandez Amin, José Manuel Aranda-Narváez, Oussama Baraket, Walter L. Biffl, Gian Luca Baiocchi, Luigi Bonavina, Giuseppe Brisinda, Luca Cardinali, Andrea Celotti, Mohamed Chaouch, Maria Chiarello, Gianluca Costa, Nicola de’Angelis, Nicolo De Manzini, Samir Delibegovic, Salomone Di Saverio, Belinda De Simone, Vincent Dubuisson, Pietro Fransvea, Gianluca Garulli, Alessio Giordano, Carlos Gomes, Firdaus Hayati, Jinjian Huang, Aini Fahriza Ibrahim, Tan Jih Huei, Ruhi Fadzlyana Jailani, Mansoor Khan, Alfonso Palmieri Luna, Manu L. N. G. Malbrain, Sanjay Marwah, Paul McBeth, Andrei Mihailescu, Alessia Morello, Francesk Mulita, Valentina Murzi, Ahmad Tarmizi Mohammad, Simran Parmar, Ajay Pak, Michael Pak-Kai Wong, Desire Pantalone, Mauro Podda, Caterina Puccioni, Kemal Rasa, Jianan Ren, Francesco Roscio, Antonio Gonzalez-Sanchez, Gabriele Sganga, Maximilian Scheiterle, Mihail Slavchev, Dmitry Smirnov, Lorenzo Tosi, Anand Trivedi, Jaime Andres Gonzalez Vega, Maciej Waledziak, Sofia Xenaki, Desmond Winter, Xiuwen Wu, Andee Dzulkarnean Zakaria, Zaidi Zakaria

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