Christopher J. Schofield

Christopher Joseph Schofield (also known as Chris Schofield) is a Professor of Chemistry at the University of Oxford and a Fellow of the Royal Society. Chris Schofield is a professor of organic chemistry at the University of Oxford, Department of Chemistry and a Fellow of Hertford College. Schofield studied functional, structural and mechanistic understanding of enzymes that employ oxygen and 2-oxoglutarate as a co-substrate. His work has opened up new possibilities in antibiotic research, oxygen sensing, and gene regulation.

After work on plant and microbial oxygenases, he studied uncharacterised human oxygenases. His research has identified unanticipated roles for oxygenases in regulating gene expression, importantly in the cellular hypoxic response, and has revealed new post-translational modifications to chromatin and RNA splicing proteins. The work has identified new opportunities for medicinal intervention. Provided by Wikipedia
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  1. 1
    Improved Synthesis of Phosphoramidite-Protected <i>N</i><sup>6</sup>-Methyladenosine via BOP-Mediated S<sub>N</sub>Ar Reaction

    Improved Synthesis of Phosphoramidite-Protected <i>N</i><sup>6</sup>-Methyladenosine via BOP-Mediated S<sub>N</sub>Ar Reaction by Shifali Shishodia, Christopher J. Schofield

    Published 2020-12-01
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  2. 2
    Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5

    Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5 by Md. Saiful Islam, Marios Markoulides, Rasheduzzaman Chowdhury, Christopher J. Schofield

    Published 2022-11-01
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  3. 3
    Ticks, ivermectin, and experimental Chagas disease

    Ticks, ivermectin, and experimental Chagas disease by João Carlos Pinto Dias, Christopher J Schofield, Evandro MM Machado, Alexandre José Fernandes

    Published 2005-12-01
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  4. 4
    Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals

    Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals by Tobias John, Elisabete Pires, Svenja S. Hester, Eidarus Salah, Richard J. Hopkinson, Christopher J. Schofield

    Published 2023-01-01
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  5. 5
    Chromosome homogeneity in populations of Triatoma brasiliensis Neiva 1911 (Hemiptera - Reduviidae - Triatominae) Homogeneidade cromossômica em populações de Triatoma brasiliensis Neiva 1911 (Hemiptera - Reduviidae - Triatominae)

    Chromosome homogeneity in populations of Triatoma brasiliensis Neiva 1911 (Hemiptera - Reduviidae - Triatominae) Homogeneidade cromossômica em populações de Triatoma brasiliensis N... by Francisco Panzera, Ruben Pérez, Paula Nicolini, Sonia Hornos, Jane Costa, Érika Borges, Liléia Diotaiuti, Christopher J. Schofield

    Published 2000-01-01
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  6. 6
    Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

    Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2 by Anka Lucic, Tika R. Malla, Karina Calvopiña, Catherine L. Tooke, Jürgen Brem, Michael A. McDonough, James Spencer, Christopher J. Schofield

    Published 2022-03-01
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  7. 7
    Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

    Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease by Ilaria Pettinati, Pawel Grzechnik, Claudia Ribeiro de Almeida, Jurgen Brem, Michael A McDonough, Somdutta Dhir, Nick J Proudfoot, Christopher J Schofield

    Published 2018-12-01
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  8. 8
    Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.

    Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours. by Cameron E Snell, Helen Turley, Alan McIntyre, Demin Li, Massimo Masiero, Christopher J Schofield, Kevin C Gatter, Adrian L Harris, Francesco Pezzella

    Published 2014-01-01
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  9. 9
    Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications

    Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications by Kuo-Feng Hsu, Sarah E. Wilkins, Richard J. Hopkinson, Rok Sekirnik, Emily Flashman, Akane Kawamura, James S.O. McCullagh, Louise J. Walport, Christopher J. Schofield

    Published 2021-01-01
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  10. 10
    Activity-based probes trap early active intermediates during metacaspase activation

    Activity-based probes trap early active intermediates during metacaspase activation by Vida Štrancar, Katarina P. van Midden, Daniel Krahn, Kyoko Morimoto, Marko Novinec, Christiane Funk, Simon Stael, Christopher J. Schofield, Marina Klemenčič, Renier A.L. van der Hoorn

    Published 2022-11-01
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  11. 11
    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates by Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe

    Published 2019-09-01
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  12. 12
    Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from <i>Escherichia coli</i>

    Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from <i>Escherichia coli</i> by Pauline A. Lang, Anete Parkova, Thomas M. Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc, Tharindi D. Panduwawala, Jules Philippe, Colin W. G. Fishwick, Peteris Trapencieris, Malcolm G. P. Page, Christopher J. Schofield, Jürgen Brem

    Published 2020-06-01
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  13. 13
    Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models

    Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models by Emily M. Harris, Jonathan D. Strope, Shaunna L. Beedie, Phoebe A. Huang, Andrew K. L. Goey, Kristina M. Cook, Christopher J. Schofield, Cindy H. Chau, Melissa M. Cadelis, Brent R. Copp, Kirk R. Gustafson, William D. Figg

    Published 2018-07-01
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  14. 14
    Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance

    Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance by Stefan Krco, Stefan Krco, Samuel J. Davis, Samuel J. Davis, Pallav Joshi, Liam A. Wilson, Marcelo Monteiro Pedroso, Marcelo Monteiro Pedroso, Andrew Douw, Christopher J. Schofield, Philip Hugenholtz, Philip Hugenholtz, Gerhard Schenk, Gerhard Schenk, Gerhard Schenk, Gerhard Schenk, Marc T. Morris, Marc T. Morris

    Published 2023-06-01
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  15. 15
    Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

    Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by Christopher J Brereton, Liudi Yao, Elizabeth R Davies, Yilu Zhou, Milica Vukmirovic, Joseph A Bell, Siyuan Wang, Robert A Ridley, Lareb SN Dean, Orestis G Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M Ewing, Aiman Alzetani, Benjamin G Marshall, Sophie V Fletcher, Philipp J Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J Schofield, Matthew Loxham, Donna E Davies, Yihua Wang, Mark G Jones

    Published 2022-02-01
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