Christopher J. Schofield

Christopher Joseph Schofield (also known as Chris Schofield) is a Professor of Chemistry at the University of Oxford and a Fellow of the Royal Society. Chris Schofield is a professor of organic chemistry at the University of Oxford, Department of Chemistry and a Fellow of Hertford College. Schofield studied functional, structural and mechanistic understanding of enzymes that employ oxygen and 2-oxoglutarate as a co-substrate. His work has opened up new possibilities in antibiotic research, oxygen sensing, and gene regulation.

After work on plant and microbial oxygenases, he studied uncharacterised human oxygenases. His research has identified unanticipated roles for oxygenases in regulating gene expression, importantly in the cellular hypoxic response, and has revealed new post-translational modifications to chromatin and RNA splicing proteins. The work has identified new opportunities for medicinal intervention. Provided by Wikipedia
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  1. 1
    Improved Synthesis of Phosphoramidite-Protected <i>N</i><sup>6</sup>-Methyladenosine via BOP-Mediated S<sub>N</sub>Ar Reaction

    Improved Synthesis of Phosphoramidite-Protected <i>N</i><sup>6</sup>-Methyladenosine via BOP-Mediated S<sub>N</sub>Ar Reaction by Shifali Shishodia, Christopher J. Schofield

    Published 2020-12-01
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  2. 2
    Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5

    Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5 by Md. Saiful Islam, Marios Markoulides, Rasheduzzaman Chowdhury, Christopher J. Schofield

    Published 2022-11-01
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  3. 3
    Ticks, ivermectin, and experimental Chagas disease

    Ticks, ivermectin, and experimental Chagas disease by João Carlos Pinto Dias, Christopher J Schofield, Evandro MM Machado, Alexandre José Fernandes

    Published 2005-12-01
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  4. 4
    Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals

    Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals by Tobias John, Elisabete Pires, Svenja S. Hester, Eidarus Salah, Richard J. Hopkinson, Christopher J. Schofield

    Published 2023-01-01
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  5. 5
    Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans

    Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans by Rasheduzzaman Chowdhury, Martine I. Abboud, James Wiley, Anthony Tumber, Suzana Markolovic, Christopher J. Schofield

    Published 2022-04-01
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  6. 6
    Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate

    Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate by Mariska de Munnik, Pauline A. Lang, Karina Calvopiña, Patrick Rabe, Jürgen Brem, Christopher J. Schofield

    Published 2024-09-01
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  7. 7
    Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes

    Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes by Giorgia Fiorini, Stephen A. Marshall, William D. Figg, William K. Myers, Lennart Brewitz, Christopher J. Schofield

    Published 2024-10-01
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  8. 8
    Chromosome homogeneity in populations of Triatoma brasiliensis Neiva 1911 (Hemiptera - Reduviidae - Triatominae) Homogeneidade cromossômica em populações de Triatoma brasiliensis Neiva 1911 (Hemiptera - Reduviidae - Triatominae)

    Chromosome homogeneity in populations of Triatoma brasiliensis Neiva 1911 (Hemiptera - Reduviidae - Triatominae) Homogeneidade cromossômica em populações de Triatoma brasiliensis N... by Francisco Panzera, Ruben Pérez, Paula Nicolini, Sonia Hornos, Jane Costa, Érika Borges, Liléia Diotaiuti, Christopher J. Schofield

    Published 2000-01-01
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  9. 9
    Dynamic kinetic resolution-mediated synthesis of C-3 hydroxylated arginine derivatives

    Dynamic kinetic resolution-mediated synthesis of C-3 hydroxylated arginine derivatives by Ye Zheng, Zhenyu Chen, Guy J. Clarkson, Stephen A. Marshall, Jianliang Xiao, Christopher J. Schofield, Martin Wills, Andrew V. Stachulski

    Published 2025-02-01
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  10. 10
    Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

    Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2 by Anka Lucic, Tika R. Malla, Karina Calvopiña, Catherine L. Tooke, Jürgen Brem, Michael A. McDonough, James Spencer, Christopher J. Schofield

    Published 2022-03-01
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  11. 11
    Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

    Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease by Ilaria Pettinati, Pawel Grzechnik, Claudia Ribeiro de Almeida, Jurgen Brem, Michael A McDonough, Somdutta Dhir, Nick J Proudfoot, Christopher J Schofield

    Published 2018-12-01
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  12. 12
    Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans.

    Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans. by Richard J Hopkinson, Ivanhoe K H Leung, Tristan J Smart, Nathan R Rose, Luc Henry, Timothy D W Claridge, Christopher J Schofield

    Published 2015-01-01
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  13. 13
    Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.

    Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours. by Cameron E Snell, Helen Turley, Alan McIntyre, Demin Li, Massimo Masiero, Christopher J Schofield, Kevin C Gatter, Adrian L Harris, Francesco Pezzella

    Published 2014-01-01
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  14. 14
    JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships

    JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships by Joanna Bonnici, Razanne Oueini, Eidarus Salah, Catrine Johansson, Elisabete Pires, Martine Abboud, Robert S. Dawber, Anthony Tumber, Patrick Rabe, Hilal Saraç, Christopher J. Schofield, Akane Kawamura

    Published 2024-11-01
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  15. 15
    Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications

    Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications by Kuo-Feng Hsu, Sarah E. Wilkins, Richard J. Hopkinson, Rok Sekirnik, Emily Flashman, Akane Kawamura, James S.O. McCullagh, Louise J. Walport, Christopher J. Schofield

    Published 2021-01-01
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  16. 16
    Activity-based probes trap early active intermediates during metacaspase activation

    Activity-based probes trap early active intermediates during metacaspase activation by Vida Štrancar, Katarina P. van Midden, Daniel Krahn, Kyoko Morimoto, Marko Novinec, Christiane Funk, Simon Stael, Christopher J. Schofield, Marina Klemenčič, Renier A.L. van der Hoorn

    Published 2022-11-01
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  17. 17
    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates by Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe

    Published 2019-09-01
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  18. 18
    Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α).

    Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). by Armin Thalhammer, Zuzana Bencokova, Rachel Poole, Christoph Loenarz, Julie Adam, Linda O'Flaherty, Johannes Schödel, David Mole, Konstantinos Giaslakiotis, Christopher J Schofield, Ester M Hammond, Peter J Ratcliffe, Patrick J Pollard

    Published 2011-01-01
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  19. 19
    Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from <i>Escherichia coli</i>

    Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from <i>Escherichia coli</i> by Pauline A. Lang, Anete Parkova, Thomas M. Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc, Tharindi D. Panduwawala, Jules Philippe, Colin W. G. Fishwick, Peteris Trapencieris, Malcolm G. P. Page, Christopher J. Schofield, Jürgen Brem

    Published 2020-06-01
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  20. 20
    SNM1A is crucial for efficient repair of complex DNA breaks in human cells

    SNM1A is crucial for efficient repair of complex DNA breaks in human cells by Lonnie P. Swift, B. Christoffer Lagerholm, Lucy R. Henderson, Malitha Ratnaweera, Hannah T. Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D. Ulrich, Joseph A. Newman, Christopher J. Schofield, Peter J. McHugh

    Published 2024-06-01
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