FLT3-ITD INDUCED MYELOPROLIFERATION CAUSES A CELL EXTRINSIC DEPLETION OF HAEMATOPOIETIC STEM CELLS door Mead, A, Atkinson, D, Kharazi, S, Chowdhury, O, Clark, SA, Matsuoka, S, Bouriez-Jones, T, Facchini, R, Booth, C, Woll, P, Suda, T, Nerlov, C, Jacobsen, SE

Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia. door Lutz, C, Woll, P, Hall, G, Castor, A, Dreau, H, Cazzaniga, G, Zuna, J, Jensen, C, Clark, SA, Biondi, A, Mitchell, C, Ferry, H, Schuh, A, Buckle, V, Jacobsen, S, Enver, T

Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia door Lutz, C, Woll, P, Hall, G, Castor, A, Dreau, H, Cazzaniga, G, Zuna, J, Jensen, C, Clark, SA, Biondi, A, Mitchell, C, Ferry, H, Schuh, A, Buckle, V, Jacobsen, S, Enver, T

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors. door Mead, A, Kharazi, S, Atkinson, D, Macaulay, I, Pecquet, C, Loughran, S, Lutteropp, M, Woll, P, Chowdhury, O, Luc, S, Buza-Vidas, N, Ferry, H, Clark, SA, Goardon, N, Vyas, P, Constantinescu, SN, Sitnicka, E, Nerlov, C, Jacobsen, SE

Presentations at the UK National Immunisation Conference door Pollard, AJ, MacDonald, NE, Dubé, E, Lamden, K, Baxter, PD, Suggitt, D, Donovan, H, Gibney, Y, Rappouli, R, Wright, C, Rodgers, E, Trotter, C, Stuartc, JM, Blake, N, Glennie, L, Lucidarme, J, Bai, X, Lekshmi, A, Willerton, L, Clark, SA, Borrow, R

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy. door Sanjuan-Pla, A, Macaulay, I, Jensen, C, Woll, P, Luis, T, Mead, A, Moore, S, Carella, C, Matsuoka, S, Bouriez Jones, T, Chowdhury, O, Stenson, L, Lutteropp, M, Green, J, Facchini, R, Boukarabila, H, Grover, A, Gambardella, A, Thongjuea, S, Carrelha, J, Tarrant, P, Atkinson, D, Clark, SA, Nerlov, C, Jacobsen, SE

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A door Brierley, CK, Yip, BH, Orlando, G, Goyal, H, Wen, S, Wen, J, Levine, MF, Jakobsdottir, GM, Rodriguez-Meira, A, Adamo, A, Bashton, M, Hamblin, A, Clark, SA, O'Sullivan, J, Murphy, L, Olijnik, AA, Cotton, A, Narina, S, Pruett-Miller, SM, Enshaei, A, Harrison, C, Drummond, M, Knapper, S, Tefferi, A, Antony-Debré, I, Thongjuea, S, Wedge, DC, Constantinescu, S, Papaemmanuil, E, Psaila, B, Crispino, JD, Mead, AJ

Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme door Carr, JP, MacLennan, JM, Plested, E, Bratcher, HB, Harrison, OB, Aley, PK, Bray, JE, Camara, S, Rodrigues, CMC, Davis, K, Bartolf, A, Baxter, D, Cameron, JC, Cunningham, R, Faust, SN, Fidler, K, Gowda, R, Heath, PT, Hughes, S, Khajuria, S, Orr, D, Raman, M, Smith, A, Turner, DPJ, Whittaker, E, Williams, CJ, Zipitis, CS, Pollard, AJ, Oliver, J, Morales-Aza, B, Lekshmi, A, Clark, SA, Borrow, R, Christensen, H, Trotter, C, Finn, A, Maiden, MC, Snape, MD

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. door Woll, P, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, D, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, A, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, I, Clark, SA, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, MS, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, J, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, SN, Nerlov, C, Nilsson, L, Campbell, P, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S, Jacobsen, S

Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and te... door Brueggemann, AB, Jansen van Rensburg, MJ, Shaw, D, McCarthy, ND, Jolley, KA, Maiden, MCJ, van der Linden, MPG, Amin-Chowdhury, Z, Bennett, DE, Borrow, R, Brandileone, M-CC, Broughton, K, Campbell, R, Cao, B, Casanova, C, Choi, EH, Chu, YW, Clark, SA, Claus, H, Coelho, J, Corcoran, M, Cottrell, S, Cunney, RJ, Dalby, T, Davies, H, de Gouveia, L, Deghmane, A-E, Demczuk, W, Desmet, S, Drew, RJ, du Plessis, M, Erlendsdottir, H, Fry, NK, Fuursted, K, Gray, SJ, Henriques-Normark, B, Hale, T, Hilty, M, Hoffmann, S, Humphreys, H, Ip, M, Jacobsson, S, Johnston, J, Kozakova, J, Kristinsson, KG, Krizova, P, Kuch, A, Ladhani, SN, Lâm, T-T, Lebedova, V