FLT3-ITD INDUCED MYELOPROLIFERATION CAUSES A CELL EXTRINSIC DEPLETION OF HAEMATOPOIETIC STEM CELLS Por Mead, A, Atkinson, D, Kharazi, S, Chowdhury, O, Clark, SA, Matsuoka, S, Bouriez-Jones, T, Facchini, R, Booth, C, Woll, P, Suda, T, Nerlov, C, Jacobsen, SE

Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia. Por Lutz, C, Woll, P, Hall, G, Castor, A, Dreau, H, Cazzaniga, G, Zuna, J, Jensen, C, Clark, SA, Biondi, A, Mitchell, C, Ferry, H, Schuh, A, Buckle, V, Jacobsen, S, Enver, T

Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia Por Lutz, C, Woll, P, Hall, G, Castor, A, Dreau, H, Cazzaniga, G, Zuna, J, Jensen, C, Clark, SA, Biondi, A, Mitchell, C, Ferry, H, Schuh, A, Buckle, V, Jacobsen, S, Enver, T

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors. Por Mead, A, Kharazi, S, Atkinson, D, Macaulay, I, Pecquet, C, Loughran, S, Lutteropp, M, Woll, P, Chowdhury, O, Luc, S, Buza-Vidas, N, Ferry, H, Clark, SA, Goardon, N, Vyas, P, Constantinescu, SN, Sitnicka, E, Nerlov, C, Jacobsen, SE

Presentations at the UK National Immunisation Conference Por Pollard, AJ, MacDonald, NE, Dubé, E, Lamden, K, Baxter, PD, Suggitt, D, Donovan, H, Gibney, Y, Rappouli, R, Wright, C, Rodgers, E, Trotter, C, Stuartc, JM, Blake, N, Glennie, L, Lucidarme, J, Bai, X, Lekshmi, A, Willerton, L, Clark, SA, Borrow, R

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy. Por Sanjuan-Pla, A, Macaulay, I, Jensen, C, Woll, P, Luis, T, Mead, A, Moore, S, Carella, C, Matsuoka, S, Bouriez Jones, T, Chowdhury, O, Stenson, L, Lutteropp, M, Green, J, Facchini, R, Boukarabila, H, Grover, A, Gambardella, A, Thongjuea, S, Carrelha, J, Tarrant, P, Atkinson, D, Clark, SA, Nerlov, C, Jacobsen, SE

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A Por Brierley, CK, Yip, BH, Orlando, G, Goyal, H, Wen, S, Wen, J, Levine, MF, Jakobsdottir, GM, Rodriguez-Meira, A, Adamo, A, Bashton, M, Hamblin, A, Clark, SA, O'Sullivan, J, Murphy, L, Olijnik, AA, Cotton, A, Narina, S, Pruett-Miller, SM, Enshaei, A, Harrison, C, Drummond, M, Knapper, S, Tefferi, A, Antony-Debré, I, Thongjuea, S, Wedge, DC, Constantinescu, S, Papaemmanuil, E, Psaila, B, Crispino, JD, Mead, AJ

Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme Por Carr, JP, MacLennan, JM, Plested, E, Bratcher, HB, Harrison, OB, Aley, PK, Bray, JE, Camara, S, Rodrigues, CMC, Davis, K, Bartolf, A, Baxter, D, Cameron, JC, Cunningham, R, Faust, SN, Fidler, K, Gowda, R, Heath, PT, Hughes, S, Khajuria, S, Orr, D, Raman, M, Smith, A, Turner, DPJ, Whittaker, E, Williams, CJ, Zipitis, CS, Pollard, AJ, Oliver, J, Morales-Aza, B, Lekshmi, A, Clark, SA, Borrow, R, Christensen, H, Trotter, C, Finn, A, Maiden, MC, Snape, MD

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. Por Woll, P, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, D, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, A, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, I, Clark, SA, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, MS, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, J, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, SN, Nerlov, C, Nilsson, L, Campbell, P, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S, Jacobsen, S

Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and te... Por Brueggemann, AB, Jansen van Rensburg, MJ, Shaw, D, McCarthy, ND, Jolley, KA, Maiden, MCJ, van der Linden, MPG, Amin-Chowdhury, Z, Bennett, DE, Borrow, R, Brandileone, M-CC, Broughton, K, Campbell, R, Cao, B, Casanova, C, Choi, EH, Chu, YW, Clark, SA, Claus, H, Coelho, J, Corcoran, M, Cottrell, S, Cunney, RJ, Dalby, T, Davies, H, de Gouveia, L, Deghmane, A-E, Demczuk, W, Desmet, S, Drew, RJ, du Plessis, M, Erlendsdottir, H, Fry, NK, Fuursted, K, Gray, SJ, Henriques-Normark, B, Hale, T, Hilty, M, Hoffmann, S, Humphreys, H, Ip, M, Jacobsson, S, Johnston, J, Kozakova, J, Kristinsson, KG, Krizova, P, Kuch, A, Ladhani, SN, Lâm, T-T, Lebedova, V