Comment on Lipsky et al.: Incidence and Risk Factors of Bleeding-Related Adverse Events in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib by Constantine S. Tam, Sarah Kamel

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Ocular toxoplasmosis during frontline venetoclax therapy for chronic lymphocytic leukaemia – more than meets the eye by Rory Bennett, Lyndell L. Lim, Constantine S. Tam

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Zanubrutinib: past, present, and future by Constantine S. Tam, Javier L. Muñoz, John F. Seymour, Stephen Opat

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Correction: Zanubrutinib: past, present, and future by Constantine S. Tam, Javier L. Muñoz, John F. Seymour, Stephen Opat

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Ibrutinib protects T cells in patients with CLL from proliferation-induced senescence by Joanne E. Davis, Chia Sharpe, Kylie Mason, Constantine S. Tam, Rachel M. Koldej, David S. Ritchie

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Ibrutinib may impair serological responses to influenza vaccination by Abby P. Douglas, Jason A. Trubiano, Ian Barr, Vivian Leung, Monica A. Slavin, Constantine S. Tam

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Severe hemolysis and transfusion reactions after treatment with BGB-3111 and PD-1 antibody for Waldenström macroglobulinemia by Jad Othman, Emma Verner, Constantine S. Tam, Jane Huang, Leo Lin, James Hilger, Judith Trotman, Robin Gasiorowski

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An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia by Md Ashik Ullah, Beatriz Garcillán, Eden Whitlock, William A. Figgett, William A. Figgett, Simona Infantino, Mahya Eslami, Mahya Eslami, SiLing Yang, M. Arifur Rahman, Yong H. Sheng, Nicholas Weber, Pascal Schneider, Constantine S. Tam, Constantine S. Tam, Fabienne Mackay, Fabienne Mackay, Fabienne Mackay, Fabienne Mackay

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Undetectable peripheral blood MRD should be the goal of venetoclax in CLL, but attainment plateaus after 24 months by Thomas E. Lew, Mary Ann Anderson, Victor S. Lin, Sasanka M. Handunnetti, Neil A. Came, Piers Blombery, David A. Westerman, Meaghan Wall, Constantine S. Tam, Andrew W. Roberts, John F. Seymour

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Concurrent ibrutinib plus venetoclax in relapsed/refractory mantle cell lymphoma: the safety run-in of the phase 3 SYMPATICO study by Michael Wang, Radhakrishnan Ramchandren, Robert Chen, Lionel Karlin, Geoffrey Chong, Wojciech Jurczak, Ka Lung Wu, Mark Bishton, Graham P. Collins, Paul Eliadis, Frédéric Peyrade, Yihua Lee, Karl Eckert, Jutta K. Neuenburg, Constantine S. Tam

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Characterization of zanubrutinib safety and tolerability profile and comparison with ibrutinib safety profile in patients with B-cell malignancies: post-hoc analysis of a large cli... by Jennifer R. Brown, Paolo Ghia, Wojciech Jurczak, Brad S. Kahl, Nicole Lamanna, Tadeusz Robak, Mazyar Shadman, Constantine S. Tam, Lugui Qiu, Jason Paik, Tommi Salmi, Liping Wang, Jun Zhang, Meng Zhang, Aileen Cohen, Han Ma, Alessandra Tedeschi

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Evaluation of bleeding risk in patients who received pirtobrutinib in the presence or absence of antithrombotic therapy by Nicole Lamanna, Constantine S. Tam, Jennifer A. Woyach, Alvaro J. Alencar, M. Lia Palomba, Pier Luigi Zinzani, Ian W. Flinn, Bita Fakhri, Jonathon B. Cohen, Arrin Kontos, Heiko Konig, Amy S. Ruppert, Anindya Chatterjee, Richard Sizelove, Livia Compte, Donald E. Tsai, Wojciech Jurczak

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Peripheral neuropathy in the phase 3 ASPEN study of Bruton tyrosine kinase inhibitors for Waldenström macroglobulinemia by Benjamin M. Heyman, Stephen S. Opat, Björn E. Wahlin, Meletios-Athanasios C. Dimopoulos, Jorge J. Castillo, Alessandra Tedeschi, Constantine S. Tam, Christian Buske, Roger G. Owen, Véronique Leblond, Judith Trotman, Gisoo Barnes, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Jeffrey V. Matous

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Long‐term outcomes of second‐line versus later‐line zanubrutinib treatment in patients with relapsed/refractory mantle cell lymphoma: An updated pooled analysis by Yuqin Song, Keshu Zhou, Dehui Zou, Dengju Li, Jianda Hu, Haiyan Yang, Huilai Zhang, Jie Ji, Wei Xu, Jie Jin, Fangfang Lv, Ru Feng, Sujun Gao, Daobin Zhou, Constantine S. Tam, David Simpson, Michael Wang, Tycel J. Phillips, Stephen Opat, Cheng Fang, Shaohui Sun, Jun Zhu

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Zanubrutinib monotherapy in relapsed/refractory mantle cell lymphoma: a pooled analysis of two clinical trials by Keshu Zhou, Dehui Zou, Jianfeng Zhou, Jianda Hu, Haiyan Yang, Huilai Zhang, Jie Ji, Wei Xu, Jie Jin, Fangfang Lv, Ru Feng, Sujun Gao, Daobin Zhou, Constantine S. Tam, David Simpson, Michael Wang, Tycel J. Phillips, Stephen Opat, Zhiyue Huang, Huafei Lu, Yuqin Song, Yongping Song

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Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma by Thijs W.H. Flinsenberg, Charnelle C. Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin Y.T. Thia, Tahereh Noori, Xiaomin Song, Han X. Aw Yeang, Daniela G. Tantalo, Sasanka Handunnetti, John F. Seymour, Andrew W. Roberts, David Ritchie, Rachel Koldej, Paul J. Neeson, Lai Wang, Joseph A. Trapani, Constantine S. Tam, Ilia Voskoboinik

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Prospective comprehensive profiling of immune responses to COVID‐19 vaccination in patients on zanubrutinib therapy by Thi H. O. Nguyen, Chhay Lim, Masa Lasica, Ashley Whitechurch, Surekha Tennakoon, Natalie R. Saunders, Lilith F. Allen, Louise C. Rowntree, Brendon Y. Chua, Lukasz Kedzierski, Hyon‐Xhi Tan, Adam K. Wheatley, Stephen J. Kent, Theo Karapanagiotidis, Suellen Nicholson, Deborah A. Williamson, Monica A. Slavin, Constantine S. Tam, Katherine Kedzierska, Benjamin W. Teh

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Zanubrutinib monotherapy for patients with treatment-naïve chronic lymphocytic leukemia and 17p deletion by Constantine S. Tam, Tadeusz Robak, Paolo Ghia, Brad S. Kahl, Patricia Walker, Wojciech Janowski, David Simpson, Mazyar Shadman, Peter S. Ganly, Luca Laurenti, Stephen Opat, Monica Tani, Hanna Ciepluch, Emma Verner, Martin Šimkovič, Anders Österborg, Marek Trněný, Alessandra Tedeschi, Jason C. Paik, Sowmya B. Kuwahara, Shibao Feng, Vanitha Ramakrishnan, Aileen Cohen, Jane Huang, Peter Hillmen, Jennifer R. Brown

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Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia by Paul Yeh, Tane Hunter, Devbarna Sinha, Sarah Ftouni, Elise Wallach, Damian Jiang, Yih-Chih Chan, Stephen Q. Wong, Maria Joao Silva, Ravikiran Vedururu, Kenneth Doig, Enid Lam, Gisela Mir Arnau, Timothy Semple, Meaghan Wall, Andjelija Zivanovic, Rishu Agarwal, Pasquale Petrone, Kate Jones, David Westerman, Piers Blombery, John F. Seymour, Anthony T. Papenfuss, Mark A. Dawson, Constantine S. Tam, Sarah-Jane Dawson

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SARS-CoV-2 Infection in Patients With Waldenström’s Macroglobulinemia: A Multicenter International Cohort Study by Irene Defrancesco, Virginia Valeria Ferretti, Pierre Morel, Charalampia Kyriakou, Efstathios Kastritis, Ibrahim Tohidi-Esfahani, Alessandra Tedeschi, Christian Buske, Ramón García-Sanz, Josephine M.I. Vos, Veronica Peri, Gloria Margiotta Casaluci, Angela Ferrari, Francesco Piazza, Rimke Oostvogels, Ester Lovato, Lydia Montes, Luc Matthieu Fornecker, Alexander Grunenberg, Meletios Athanasios Dimopoulos, Constantine S. Tam, Shirley D’Sa, Veronique Leblond, Judith Trotman, Francesco Passamonti, Luca Arcaini, Marzia Varettoni, on behalf of the European Consortium for Waldenström’s Macroglobulinemia

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