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Cristen Willer

Cristen Jennifer Willer (born 1976) is an American-Canadian bioinformatician and geneticist. She works at Regeneron Pharmaceuticals, and was formerly, until 2022, the Frank N Wilson Professor of Internal Medicine, Human Genetics, and Computational Medicine and Bioinformatics at the University of Michigan. Provided by Wikipedia

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Unravelling the genetic architecture of human complex traits through whole genome sequencing by Ozvan Bocher, Cristen J. Willer, Eleftheria Zeggini

Published 2023-06-01

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2

Genome-scale CRISPR screening for modifiers of cellular LDL uptake. by Brian T Emmer, Emily J Sherman, Paul J Lascuna, Sarah E Graham, Cristen J Willer, David Ginsburg

Published 2021-01-01

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3

Identification of cell type specific ACE2 modifiers by CRISPR screening. by Emily J Sherman, Carmen Mirabelli, Vi T Tang, Taslima G Khan, Kyle Leix, Andrew A Kennedy, Sarah E Graham, Cristen J Willer, Andrew W Tai, Jonathan Z Sexton, Christiane E Wobus, Brian T Emmer

Published 2022-03-01

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4

The Michigan Genomics Initiative: A biobank linking genotypes and electronic clinical records in Michigan Medicine patients by Matthew Zawistowski, Lars G. Fritsche, Anita Pandit, Brett Vanderwerff, Snehal Patil, Ellen M. Schmidt, Peter VandeHaar, Cristen J. Willer, Chad M. Brummett, Sachin Kheterpal, Xiang Zhou, Michael Boehnke, Gonçalo R. Abecasis, Sebastian Zöllner

Published 2023-02-01

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5

Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. by Ingrid Brænne, Lingyao Zeng, Christina Willenborg, Vinicius Tragante, Thorsten Kessler, CARDIoGRAM Consortium, CARDIoGRAMplusC4D Consortium, Cristen J Willer, Markku Laakso, Lars Wallentin, Paul W Franks, Veikko Salomaa, Abbas Dehghan, Thomas Meitinger, Nilesh J Samani, Folkert W Asselbergs, Jeanette Erdmann, Heribert Schunkert

Published 2017-01-01

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Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents. by Kuan-Han H Wu, Whitney E Hornsby, Bethany Klunder, Amelia Krause, Anisa Driscoll, John Kulka, Ryan Bickett-Hickok, Austin Fellows, Sarah Graham, Erin O Kaleba, Salim S Hayek, Xu Shi, Nadia R Sutton, Nicholas Douville, Bhramar Mukherjee, Kenneth Jamerson, Chad M Brummett, Cristen J Willer

Published 2021-01-01

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A Novel Variant in APOB Gene Causes Extremely Low LDL-C Without Known Adverse Effects by Ida Surakka, PhD, Whitney E. Hornsby, PhD, Linda Farhat, MS, Melvyn Rubenfire, MD, Lars G. Fritsche, PhD, Kristian Hveem, MD, PhD, Y. Eugene Chen, MD, PhD, Robert D. Brook, MD, Cristen J. Willer, PhD, Richard L. Weinberg, MD, PhD

Published 2020-05-01

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Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT by Marta R. Moksnes, Sarah E. Graham, Kuan-Han Wu, Ailin Falkmo Hansen, Sarah A. Gagliano Taliun, Wei Zhou, Ketil Thorstensen, Lars G. Fritsche, Dipender Gill, Amy Mason, Francesco Cucca, David Schlessinger, Gonçalo R. Abecasis, Stephen Burgess, Bjørn Olav Åsvold, Jonas B. Nielsen, Kristian Hveem, Cristen J. Willer, Ben M. Brumpton

Published 2022-06-01

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Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis by Sarah E. Graham, Jonas B. Nielsen, Matthew Zawistowski, Wei Zhou, Lars G. Fritsche, Maiken E. Gabrielsen, Anne Heidi Skogholt, Ida Surakka, Whitney E. Hornsby, Damian Fermin, Daniel B. Larach, Sachin Kheterpal, Chad M. Brummett, Seunggeun Lee, Hyun Min Kang, Goncalo R. Abecasis, Solfrid Romundstad, Stein Hallan, Matthew G. Sampson, Kristian Hveem, Cristen J. Willer

Published 2019-04-01

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Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2 by Yanbo Fan, Brooke N. Wolford, Haocheng Lu, Wenying Liang, Jinjian Sun, Wei Zhou, Oren Rom, Anubha Mahajan, Ida Surakka, Sarah E. Graham, Zhipeng Liu, Hyunbae Kim, Shweta Ramdas, Lars G. Fritsche, Jonas B. Nielsen, Maiken Elvestad Gabrielsen, Kristian Hveem, Dongshan Yang, Jun Song, Minerva T. Garcia-Barrio, Jifeng Zhang, Wanqing Liu, Kezhong Zhang, Cristen J. Willer, Y. Eugene Chen

Published 2021-11-01

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Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits by Ananyo Choudhury, Jean-Tristan Brandenburg, Tinashe Chikowore, Dhriti Sengupta, Palwende Romuald Boua, Nigel J. Crowther, Godfred Agongo, Gershim Asiki, F. Xavier Gómez-Olivé, Isaac Kisiangani, Eric Maimela, Matshane Masemola-Maphutha, Lisa K. Micklesfield, Engelbert A. Nonterah, Shane A. Norris, Hermann Sorgho, Halidou Tinto, Stephen Tollman, Sarah E. Graham, Cristen J. Willer, AWI-Gen study, H3Africa Consortium, Scott Hazelhurst, Michèle Ramsay

Published 2022-05-01

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Author Correction: Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits by Ananyo Choudhury, Jean-Tristan Brandenburg, Tinashe Chikowore, Dhriti Sengupta, Palwende Romuald Boua, Nigel J. Crowther, Godfred Agongo, Gershim Asiki, F. Xavier Gómez-Olivé, Isaac Kisiangani, Eric Maimela, Matshane Masemola-Maphutha, Lisa K. Micklesfield, Engelbert A. Nonterah, Shane A. Norris, Hermann Sorgho, Halidou Tinto, Stephen Tollman, Sarah E. Graham, Cristen J. Willer, AWI-Gen study, H3Africa Consortium, Scott Hazelhurst, Michèle Ramsay

Published 2022-08-01

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A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans by Marta R. Moksnes, Ailin F. Hansen, Brooke N. Wolford, Laurent F. Thomas, Humaira Rasheed, Anica Simić, Laxmi Bhatta, Anne Lise Brantsæter, Ida Surakka, Wei Zhou, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Tore Syversen, Jie Zheng, Lars G. Fritsche, David M. Evans, Nicole M. Warrington, Therese H. Nøst, Bjørn Olav Åsvold, Trond Peder Flaten, Cristen J. Willer, Kristian Hveem, Ben M. Brumpton

Published 2024-04-01

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$MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk$

MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk by Ida Surakka, Lars G. Fritsche, Wei Zhou, Joshua Backman, Jack A. Kosmicki, Haocheng Lu, Ben Brumpton, Jonas B. Nielsen, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, Sarah E. Graham, Y. Eugene Chen, Seunggeun Lee, Hyun Min Kang, Arnulf Langhammer, Siri Forsmo, Bjørn O. Åsvold, Unnur Styrkarsdottir, Hilma Holm, Daniel Gudbjartsson, Kari Stefansson, Aris Baras, Regeneron Genetics Center, Goncalo R. Abecasis, Kristian Hveem, Cristen J. Willer

Published 2020-10-01

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Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals by Kira J. Stanzick, Yong Li, Pascal Schlosser, Mathias Gorski, Matthias Wuttke, Laurent F. Thomas, Humaira Rasheed, Bryce X. Rowan, Sarah E. Graham, Brett R. Vanderweff, Snehal B. Patil, VA Million Veteran Program, Cassiane Robinson-Cohen, John M. Gaziano, Christopher J. O’Donnell, Cristen J. Willer, Stein Hallan, Bjørn Olav Åsvold, Andre Gessner, Adriana M. Hung, Cristian Pattaro, Anna Köttgen, Klaus J. Stark, Iris M. Heid, Thomas W. Winkler

Published 2021-07-01

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COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study by Kaya Kvarme Jacobsen, Sigrid Børte, Lene Bjerke Laborie, Hege Kristiansen, Annette Schäfer, Trude Gundersen, Tetyana Zayats, Bendik Kristoffer Slagsvold Winsvold, Karen Rosendahl, Amy E. Martinsen, Anne Heidi Skogholt, Ben M. Brumpton, Cristen J. Willer, Egil A. Fors, Espen S. Kristoffersen, Ingrid Heuch, Ingunn Mundal, John-Anker Zwart, Jonas B. Nielsen, Kjersti Storheim, Knut Hagen, Kristian Bernhard Nilsen, Kristian Hveem, Lars G. Fritsche, Laurent F. Thomas, Linda M. Pedersen, Maiken E. Gabrielsen, Marie U. Lie, Synne Ø. Stensland, Wei Zhou

Published 2024-03-01

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17

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals by Pradeep Natarajan, Gina M. Peloso, Seyedeh Maryam Zekavat, May Montasser, Andrea Ganna, Mark Chaffin, Amit V. Khera, Wei Zhou, Jonathan M. Bloom, Jesse M. Engreitz, Jason Ernst, Jeffrey R. O’Connell, Sanni E. Ruotsalainen, Maris Alver, Ani Manichaikul, W. Craig Johnson, James A. Perry, Timothy Poterba, Cotton Seed, Ida L. Surakka, Tonu Esko, Samuli Ripatti, Veikko Salomaa, Adolfo Correa, Ramachandran S. Vasan, Manolis Kellis, Benjamin M. Neale, Eric S. Lander, Goncalo Abecasis, Braxton Mitchell, Stephen S. Rich, James G. Wilson, L. Adrienne Cupples, Jerome I. Rotter, Cristen J. Willer, Sekar Kathiresan, NHLBI TOPMed Lipids Working Group

Published 2018-08-01

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Genome-wide analysis yields new loci associating with aortic valve stenosis by Anna Helgadottir, Gudmar Thorleifsson, Solveig Gretarsdottir, Olafur A. Stefansson, Vinicius Tragante, Rosa B. Thorolfsdottir, Ingileif Jonsdottir, Thorsteinn Bjornsson, Valgerdur Steinthorsdottir, Niek Verweij, Jonas B. Nielsen, Wei Zhou, Lasse Folkersen, Andreas Martinsson, Mahyar Heydarpour, Siddharth Prakash, Gylfi Oskarsson, Tomas Gudbjartsson, Arnar Geirsson, Isleifur Olafsson, Emil L. Sigurdsson, Peter Almgren, Olle Melander, Anders Franco-Cereceda, Anders Hamsten, Lars Fritsche, Maoxuan Lin, Bo Yang, Whitney Hornsby, Dongchuan Guo, Chad M. Brummett, Gonçalo Abecasis, Michael Mathis, Dianna Milewicz, Simon C. Body, Per Eriksson, Cristen J. Willer, Kristian Hveem, Christopher Newton-Cheh, J. Gustav Smith, Ragnar Danielsen, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm, Kari Stefansson

Published 2018-03-01

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Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis by George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope Blakely, Ayse Bilge Ozel, Sarah Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekmulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thørner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Søren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, on behalf of the DBDS Consortium, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, on behalf of the Regeneron Genetics Center, Gunnar Engström, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek

Published 2022-12-01

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Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve by Bo Yang, Wei Zhou, Jiao Jiao, Jonas B. Nielsen, Michael R. Mathis, Mahyar Heydarpour, Guillaume Lettre, Lasse Folkersen, Siddharth Prakash, Claudia Schurmann, Lars Fritsche, Gregory A. Farnum, Maoxuan Lin, Mohammad Othman, Whitney Hornsby, Anisa Driscoll, Alexandra Levasseur, Marc Thomas, Linda Farhat, Marie-Pierre Dubé, Eric M. Isselbacher, Anders Franco-Cereceda, Dong-chuan Guo, Erwin P. Bottinger, G. Michael Deeb, Anna Booher, Sachin Kheterpal, Y. Eugene Chen, Hyun Min Kang, Jacob Kitzman, Heather J. Cordell, Bernard D. Keavney, Judith A. Goodship, Santhi K. Ganesh, Gonçalo Abecasis, Kim A. Eagle, Alan P. Boyle, Ruth J. F. Loos, Per Eriksson, Jean-Claude Tardif, Chad M. Brummett, Dianna M. Milewicz, Simon C. Body, Cristen J. Willer

Published 2017-05-01

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