66942 Metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure per Raymond J. Langley, Marie M. Migaud, D. Clark Files, Peter Morris

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Response to physical rehabilitation and recovery trajectories following critical illness: individual participant data meta-analysis protocol per Ian Gordon, Linda Denehy, Amalia Karahalios, D Clark Files, Jennifer R A Jones, Sue Berney, Michael J Berry, David M Griffith, Luke A McDonald, Peter E Morris, Marc Moss, Amy Nordon-Craft, Timothy Walsh, Zudin Puthucheary, D Clark Files

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Skeletal Muscle Myofibers Directly Contribute to LPS-Induced Systemic Inflammatory Tone per Joseph J. Bivona III, Madeleine M. Mank, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter

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Activated mast cells in skeletal muscle can be a potential mediator for cancer‐associated cachexia per D. Brooke Widner, Chun Liu, Qingxia Zhao, Sarah Sharp, Matthew R. Eber, Sun H. Park, D. Clark Files, Yusuke Shiozawa

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Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation... per Daren K Heyland, Andrew Day, G John Clarke, Catherine (Terri) Hough, D Clark Files, Marina Mourtzakis, Nicolaas Deutz, Dale M Needham, Renee Stapleton

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Macrophages modulate skeletal muscle wasting and recovery in acute lung injury in mice per Jennifer T. W. Krall, Lanazha Belfield, Claire Strysick, Chun Liu, Lina Purcell, Renee Stapleton, Michael Toth, Matthew Poynter, Xuewei Zhu, Kevin Gibbs, D. Clark Files

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Elevated Driving Pressure and Elastance Does Not Increase In-Hospital Mortality Among Obese and Severely Obese Patients With Ventilator Dependent Respiratory Failure per Charles Terry, MD, MSCR, Daniel Brinton, PhD, Annie N. Simpson, PhD, Katie Kirchoff, MS, D. Clark Files, MD, George Carter, MD, Dee W. Ford, MD, MSCR, Andrew J. Goodwin, MD, MSCR

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Driving Pressure, Elastance, and Outcomes in a Real-World Setting: A Bi-Center Analysis of Electronic Health Record Data per Andrew J. Goodwin, MD, MSCR, Daniel L. Brinton, PhD, Charles Terry, MD, MSCR, George Carter, MD, D. Clark Files, MD, Katie Kirchoff, MS, Dee W. Ford, MD, MSCR, Annie N. Simpson, PhD

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A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure per Raymond J. Langley, Marie E. Migaud, Lori Flores, J. Will Thompson, Elizabeth A. Kean, Murphy M. Mostellar, Matthew Mowry, Patrick Luckett, Lina D. Purcell, James Lovato, Sheetal Gandotra, Ryan Benton, D. Clark Files, Kevin S. Harrod, Mark N. Gillespie, Peter E. Morris

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Modeling clinical trajectory status of critically ill COVID-19 patients over time: A method for analyzing discrete longitudinal and ordinal outcomes per Michael J. Ward, David J. Douin, Wu Gong, Adit A. Ginde, Catherine L. Hough, Matthew C. Exline, Mark W. Tenforde, William B. Stubblefield, Jay S. Steingrub, Matthew E. Prekker, Akram Khan, D. Clark Files, Kevin W. Gibbs, Todd W. Rice, Jonathan D. Casey, Daniel J. Henning, Jennifer G. Wilson, Samuel M. Brown, Manish M. Patel, Wesley H. Self, Christopher J. Lindsell, for the Influenza and Other Viruses in the Acutely Ill (IVY) Network

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Validation of a Novel, Rapid Sepsis Diagnostic for Emergency Department Use per Hollis R. O’Neal, Jr, MD, MSc, Roya Sheybani, PhD, David R. Janz, MD, MSc, Robert Scoggins, MD, PhD, Tonya Jagneaux, MD, James E. Walker, MD, PhD, Daniel J. Henning, MD, MPH, Elizabeth Rosenman, MD, Simon A. Mahler, MD, MS, Hariharan Regunath, MD, Christopher S. Sampson, MD, D. Clark Files, MD, Richard D. Fremont, MD, Michael J. Noto, MD, PhD, Erica E. Schneider, MD, Wesley R. Shealey, MD, Matthew S. Berlinger, MD, Thomas C. Carver, MD, Morgan K. Walker, MD, Nathan A. Ledeboer, PhD, Ajay M. Shah, PhD, Henry T.K. Tse, PhD, Dino DiCarlo, PhD, Todd W. Rice, MD, MSc, Christopher B. Thomas, MD

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ICU Bed Utilization During the Coronavirus Disease 2019 Pandemic in a Multistate Analysis—March to June 2020 per David J. Douin, MD, Michael J. Ward, MD, PhD, Christopher J. Lindsell, PhD, Michelle P. Howell, BSN, Catherine L. Hough, MD, MSc, Matthew C. Exline, MD, Michelle N. Gong, MD, Michael S. Aboodi, MD, Mark W. Tenforde, MD, PhD, Leora R. Feldstein, PhD, William B. Stubblefield, MD, Jay S. Steingrub, MD, Matthew E. Prekker, MD, MPH, Samuel M. Brown, MD, Ithan D. Peltan, MD, MSc, Akram Khan, MD, D. Clark Files, MD, Kevin W. Gibbs, MD, Todd W. Rice, MD, MSc, Jonathan D. Casey, MD, David N. Hager, MD, PhD, Nida Qadir, MD, Daniel J. Henning, MD, Jennifer G. Wilson, MD, MS, Manish M. Patel, MD, Wesley H. Self, MD, MPH, Adit A. Ginde, MD, MPH

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Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines per Li Wang, Markus H. Kainulainen, Nannan Jiang, Han Di, Gaston Bonenfant, Lisa Mills, Michael Currier, Punya Shrivastava-Ranjan, Brenda M. Calderon, Mili Sheth, Brian R. Mann, Jaber Hossain, Xudong Lin, Sandra Lester, Elizabeth A. Pusch, Joyce Jones, Dan Cui, Payel Chatterjee, M. Harley Jenks, Esther K. Morantz, Gloria P. Larson, Masato Hatta, Jennifer L. Harcourt, Azaibi Tamin, Yan Li, Ying Tao, Kun Zhao, Kristine Lacek, Ashley Burroughs, Wei Wang, Malania Wilson, Terianne Wong, So Hee Park, Suxiang Tong, John R. Barnes, Mark W. Tenforde, Wesley H. Self, Nathan I. Shapiro, Matthew C. Exline, D. Clark Files, Kevin W. Gibbs, David N. Hager, Manish Patel, Alison L. Halpin, Laura K. McMullan, Justin S. Lee, Hongjie Xia, Xuping Xie, Pei-Yong Shi, C. Todd Davis, Christina F. Spiropoulou, Natalie J. Thornburg, M. Steven Oberste, Vivien G. Dugan, SSEV Bioinformatics Working Group, David E. Wentworth, Bin Zhou

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Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trialResearch in context per D. Clark Files, Neil Aggarwal, Timothy Albertson, Sara Auld, Jeremy R. Beitler, Paul Berger, Ellen L. Burnham, Carolyn S. Calfee, Nathan Cobb, Alessio Crippa, Andrea Discacciati, Martin Eklund, Laura Esserman, Eliot Friedman, Sheetal Gandotra, Kashif Khan, Jonathan Koff, Santhi Kumar, Kathleen D. Liu, Thomas R. Martin, Michael A. Matthay, Nuala J. Meyer, Timothy Obermiller, Philip Robinson, Derek Russell, Karl Thomas, Se Fum Wong, Richard G. Wunderink, Mark M. Wurfel, Albert Yen, Fady A. Youssef, Anita Darmanian, Amy L. Dzierba, Ivan Garcia, Katarzyna Gosek, Purnema Madahar, Aaron M. Mittel, Justin Muir, Amanda Rosen, John Schicchi, Alexis L. Serra, Romina Wahab, Kevin W. Gibbs, Leigha Landreth, Mary LaRose, Lisa Parks, Adina Wynn, Caroline A.G. Ittner, Nilman S. Mangalmurti, John P. Reilly, Donna Harris, Abhishek Methukupally, Siddharth Patel, Lindsie Boerger, John Kazianis, Carrie Higgins, Jeff McKeehan, Brian Daniel, Scott Fields, James Hurst-Hopf, Alejandra Jauregui, Lamorna Brown Swigart, Daniel Blevins, Catherine Nguyen, Alexis Suarez, Maged A. Tanios, Farjad Sarafian, Usman Shah, Max Adelman, Christina Creel-Bulos, Joshua Detelich, Gavin Harris, Katherine Nugent, Christina Spainhour, Philip Yang, Angela Haczku, Erin Hardy, Richart Harper, Brian Morrissey, Christian Sandrock, G. R. Scott Budinger, Helen K. Donnelly, Benjamin D. Singer, Ari Moskowitz, Melissa Coleman, Joseph Levitt, Ruixiao Lu, Paul Henderson, Adam Asare, Imogene Dunn, Alejandro Botello Barragan

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Trend in Clinical Trial Participation During COVID-19: A Secondary Analysis of the I-SPY COVID Clinical Trial per Philip Yang, MD, MSc, Neal W. Dickert, MD, PhD, Angela Haczku, MD, PhD, Christine Spainhour, RN, CCRC, Sara C. Auld, MD, MSc, the I-SPY COVID Consortium, Neil R. Aggarwal, MD, MHSc, Timothy Albertson, MD, Sara Auld, MD, Jeremy R. Beitler, MD, MPH, Paul Berger, DO, Ellen L. Burnham, MD, Carolyn S. Calfee, MD, MAS, Nathan Cobb, MD, Alessio Crippa, PhD, Andrea Discacciati, PhD, Martin Eklund, PhD, Laura Esserman, MD, MBA, D. Clark Files, MD, Eliot Friedman, MD, Sheetal Gandotra, MD, Kashif Khan, MD, Jonathan Koff, MD, Santhi Kumar, MD, Kathleen D. Liu, MD, PhD, Thomas R. Martin, MD, Michael A. Matthay, MD, Nuala J. Meyer, MD, Timothy Obermiller, MD, MS, Philip Robinson, MD, Derek Russell, MD, Karl Thomas, MD, Se Fum Wong, MD, Richard G. Wunderink, MD, Mark M. Wurfel, PhD, MD, Albert Yen, MD, Fady A. Youssef, MD, Anita Darmanian, MD, Amy L. Dzierba, PharmD, Ivan Garcia, RRT, Katarzyna Gosek, PharmD, Purnema Madahar, MD, MS, Aaron M. Mittel, MD, Justin Muir, PharmD, Amanda Roden, MD, John Schicchi, MD, Alexis L. Serra, MD, MPH, Romina Wahab, MD, Kevin W. Gibbs, MD, Leigha Landreth, RN, Mary LaRose, RN, Lisa Parks, RN, Adina Wynn, MPH, CCRP, Caroline A. G. Ittner, PhD, Nilam S. Mangalmurti, MD, John P. Reilly, MD, MS, Donna Harris, BSN, Abhishek Methukupally, MBBS, Siddharth Patel, MBBS, MPH, Lindsie Boerger, BA, John Kazianis, MD, Carrie Higgins, Jeff McKeehan, MS, Brian Daniel, RCP, RRT, Scott Fields, PharmD, James Hurst-Hopf, MS, Alejandra Jauregui, BA, Lamorna Brown Swigart, PhD, Daniel Belvins, CCRP, Catherine Nguyen, MD, Alexis Suarez, MS, Maged A. Tanios, MD, Farjad Sarafian, MD, Usman Shah, MD, Max Adelman, MD, MSc, Christina Creel-Bulos, MD, Joshua Detelich, MD, Gavin Harris, MD, Katherine Nugent, MD, Christine Spainhour, RN, CCRC, Philip Yang, MD, Angela Haczku, MD, PhD, Erin Hardy, Richart Harper, MD, Brian Morrissey, MD, Christian Sandrock, MD, MPH, G. R. Scott Budinger, MD, Helen K. Donnelly, RN, BSN, Benjamin D. Singer, MD, Ari Moskowitz, MD, Melissa Coleman, MD, Joseph Levitt, MD, Ruixiao Lu, PhD, Paul Henderson, PhD, Adam Asare, PhD, Imogene Dunn, PhD, Alejandro Botello Barragan

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