Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response ‌ Mohammed Bensellam, D. Ross Laybutt, Jean-Christophe Jonas

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Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells. ‌ Mohammed Bensellam, Bertrand Duvillié, Galyna Rybachuk, D Ross Laybutt, Christophe Magnan, Yves Guiot, Jacques Pouysségur, Jean-Christophe Jonas

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Circular RNAs as novel regulators of β-cell functions in normal and disease conditions ‌ Lisa Stoll, Jonathan Sobel, Adriana Rodriguez-Trejo, Claudiane Guay, Kailun Lee, Morten Trillingsgaard Venø, Jørgen Kjems, D. Ross Laybutt, Romano Regazzi

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Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes. ‌ Sarita Dhounchak, Sarah K Popp, Debra J Brown, D Ross Laybutt, Trevor J Biden, Stefan R Bornstein, Christopher R Parish, Charmaine J Simeonovic

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Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia. ‌ Andreia V Pinho, Mohammed Bensellam, Elke Wauters, Maxine Rees, Marc Giry-Laterriere, Amanda Mawson, Le Quan Ly, Andrew V Biankin, Jianmin Wu, D Ross Laybutt, Ilse Rooman

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Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes ‌ Anna Motterle, Sonia Gattesco, Marie-Line Peyot, Jonathan Lou S. Esguerra, Ana Gomez-Ruiz, D. Ross Laybutt, Patrick Gilon, Frédéric Burdet, Mark Ibberson, Lena Eliasson, Marc Prentki, Romano Regazzi

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Iron chelation increases beige fat differentiation and metabolic activity, preventing and treating obesity ‌ Mojgan Nazari, Kenneth W. Ho, Natasha Langley, Kuan M. Cha, Raymond Kodsi, Mawson Wang, D. Ross Laybutt, Kim Cheng, Rebecca A. Stokes, Michael M. Swarbrick, Jenny E. Gunton

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Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance. ‌ Lu-Ping Ren, Stanley M H Chan, Xiao-Yi Zeng, D Ross Laybutt, Tristan J Iseli, Ruo-Qiong Sun, Edward W Kraegen, Gregory J Cooney, Nigel Turner, Ji-Ming Ye

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β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes ‌ Amit Lalwani, Joanna Warren, David Liuwantara, Wayne J. Hawthorne, Philip J. O’Connell, Frank J. Gonzalez, Rebecca A. Stokes, Jennifer Chen, D. Ross Laybutt, Maria E. Craig, Michael M. Swarbrick, Cecile King, Jenny E. Gunton

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Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling. ‌ Jenny E Gunton, Mary Sisavanh, Rebecca A Stokes, Jon Satin, Leslie S Satin, Min Zhang, Sue M Liu, Weikang Cai, Kim Cheng, Gregory J Cooney, D Ross Laybutt, Trina So, Juan-Carlos Molero, Shane T Grey, Douglas A Andres, Michael S Rolph, Charles R Mackay

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Inhibition of Y1 receptor signaling improves islet transplant outcome ‌ Kim Loh, Yan-Chuan Shi, Stacey Walters, Mohammed Bensellam, Kailun Lee, Katsuya Dezaki, Masanori Nakata, Chi Kin Ip, Jeng Yie Chan, Esteban N. Gurzov, Helen E. Thomas, Michaela Waibel, James Cantley, Thomas W. Kay, Toshihiko Yada, D. Ross Laybutt, Shane T. Grey, Herbert Herzog

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Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes ‌ Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G. Pappas, Xin Liu, John W. Scott, Jonathan S. Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L. Eizirik, D. Ross Laybutt, Herbert Herzog, Helen E. Thomas, Kim Loh

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Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity ‌ Chenxu Yan, Tianshu Zeng, Kailun Lee, Max Nobis, Kim Loh, Luoning Gou, Zefeng Xia, Zhongmin Gao, Mohammed Bensellam, Will Hughes, Jackie Lau, Lei Zhang, Chi Kin Ip, Ronaldo Enriquez, Hanyu Gao, Qiao-Ping Wang, Qi Wu, Jody J. Haigh, D. Ross Laybutt, Paul Timpson, Herbert Herzog, Yan-Chuan Shi

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A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. ‌ Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating

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