An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartmen... by Santeri Pakola, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Tatiana V. Kudling, James H. A. Clubb, James H. A. Clubb, Susanna Grönberg-Vähä-Koskela, Susanna Grönberg-Vähä-Koskela, Saru Basnet, Elise Jirovec, Elise Jirovec, Victor Arias, Lyna Haybout, Lyna Haybout, Camilla Heiniö, Joao M. Santos, Joao M. Santos, Victor Cervera-Carrascon, Victor Cervera-Carrascon, Riikka Havunen, Riikka Havunen, Marjukka Anttila, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

Get full text

Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1 by Dafne C. A. Quixabeira, Victor Cervera-Carrascon, Joao M. Santos, James H.A. Clubb, Tatiana V. Kudling, Saru Basnet, Camilla Heiniö, Susanna Grönberg-Vähä-Koskela, Marjukka Anttila, Riikka Havunen, Anna Kanerva, Akseli Hemminki

Get full text

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition by Victor Cervera-Carrascon, Dafne C.A. Quixabeira, Joao Manuel Santos, Riikka Havunen, Sadia Zafar, Otto Hemminki, Camilla Heiniö, Eleonora Munaro, Mikko Siurala, Suvi Sorsa, Tuomas Mirtti, Petrus Järvinen, Markus Mildh, Harry Nisen, Antti Rannikko, Marjukka Anttila, Anna Kanerva, Akseli Hemminki

Get full text

Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors by Saru Basnet, Joao M. Santos, Dafne C.A. Quixabeira, James H.A. Clubb, Susanna A.M. Grönberg-Vähä-Koskela, Victor Arias, Santeri Pakola, Tatiana V. Kudling, Camilla Heiniö, Riikka Havunen, Victor Cervera-Carrascon, Suvi Sorsa, Marjukka Anttila, Anna Kanerva, Akseli Hemminki

Get full text

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting by James H. A. Clubb, James H. A. Clubb, James H. A. Clubb, Tatiana V. Kudling, Tatiana V. Kudling, Mykhailo Girych, Lyna Haybout, Lyna Haybout, Santeri Pakola, Santeri Pakola, Firas Hamdan, Firas Hamdan, Víctor Cervera-Carrascon, Víctor Cervera-Carrascon, Víctor Cervera-Carrascon, Annabrita Hemmes, Susanna Grönberg-Vähä-Koskela, Susanna Grönberg-Vähä-Koskela, Susanna Grönberg-Vähä-Koskela, João Manuel Santos, João Manuel Santos, João Manuel Santos, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Saru Basnet, Saru Basnet, Camilla Heiniö, Camilla Heiniö, Victor Arias, Victor Arias, Elise Jirovec, Elise Jirovec, Shreyas Kaptan, Riikka Havunen, Riikka Havunen, Riikka Havunen, Suvi Sorsa, Suvi Sorsa, Suvi Sorsa, Abdullah Erikat, Joel Schwartz, Marjukka Anttila, Katri Aro, Katri Aro, Tapani Viitala, Ilpo Vattulainen, Vincenzo Cerullo, Vincenzo Cerullo, Anna Kanerva, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

Get full text

Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors by Victor Cervera-Carrascon, Dafne C.A. Quixabeira, Riikka Havunen, Joao M. Santos, Emma Kutvonen, James H.A. Clubb, Mikko Siurala, Camilla Heiniö, Sadia Zafar, Teija Koivula, Dave Lumen, Marjo Vaha, Arturo Garcia-Horsman, Anu J. Airaksinen, Suvi Sorsa, Marjukka Anttila, Veijo Hukkanen, Anna Kanerva, Akseli Hemminki

Get full text

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer by James H. A. Clubb, James H. A. Clubb, James H. A. Clubb, Tatiana V. Kudling, Tatiana V. Kudling, Camilla Heiniö, Camilla Heiniö, Saru Basnet, Saru Basnet, Santeri Pakola, Santeri Pakola, Víctor Cervera Carrascón, Víctor Cervera Carrascón, Víctor Cervera Carrascón, João Manuel Santos, João Manuel Santos, João Manuel Santos, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Riikka Havunen, Riikka Havunen, Riikka Havunen, Suvi Sorsa, Suvi Sorsa, Suvi Sorsa, Vincent Zheng, Vincent Zheng, Tuula Salo, Tuula Salo, Tuula Salo, Tuula Salo, Tuula Salo, Leif Bäck, Leif Bäck, Katri Aro, Katri Aro, Sanni Tulokas, Venla Loimu, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

Get full text

Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer by Tatiana V. Kudling, James H.A. Clubb, Santeri Pakola, Dafne C.A. Quixabeira, Iris A.K. Lähdeniemi, Camilla Heiniö, Victor Arias, Riikka Havunen, Victor Cervera-Carrascon, Joao M. Santos, Eva Sutinen, Jari Räsänen, Kristian Borenius, Mikko I. Mäyränpää, Eero Aaltonen, Suvi Sorsa, Otto Hemminki, Anna Kanerva, Emmy W. Verschuren, Ilkka Ilonen, Akseli Hemminki

Get full text

Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1 by Victor Cervera-Carrascon, Victor Cervera-Carrascon, Dafne C. A. Quixabeira, Joao M. Santos, Joao M. Santos, Riikka Havunen, Riikka Havunen, Ioanna Milenova, Ioanna Milenova, Jan Verhoeff, Camilla Heiniö, Sadia Zafar, Juan J. Garcia-Vallejo, Victor W. van Beusechem, Tanja D. de Gruijl, Aino Kalervo, Suvi Sorsa, Anna Kanerva, Anna Kanerva, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

Get full text

Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression by Tatiana V. Kudling, James H.A. Clubb, Dafne C.A. Quixabeira, Joao M. Santos, Riikka Havunen, Alexander Kononov, Camilla Heiniö, Victor Cervera-Carrascon, Santeri Pakola, Saru Basnet, Susanna Grönberg-Vähä-Koskela, Victor Arias, Ivan Gladwyn-Ng, Katri Aro, Leif Bäck, Jari Räsänen, Ilkka Ilonen, Kristian Borenius, Mikko Räsänen, Otto Hemminki, Antti Rannikko, Anna Kanerva, Johanna Tapper, Akseli Hemminki

Get full text