AmpliconDesign – an interactive web server for the design of high-throughput targeted DNA methylation assays by Maximilian Schönung, Jana Hess, Pascal Bawidamann, Sina Stäble, Joschka Hey, Jens Langstein, Yassen Assenov, Dieter Weichenhan, Pavlo Lutsik, Daniel B. Lipka

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Effects of Label Noise on Deep Learning-Based Skin Cancer Classification by Achim Hekler, Jakob N. Kather, Jakob N. Kather, Eva Krieghoff-Henning, Jochen S. Utikal, Jochen S. Utikal, Friedegund Meier, Friedegund Meier, Frank F. Gellrich, Frank F. Gellrich, Julius Upmeier zu Belzen, Lars French, Justin G. Schlager, Kamran Ghoreschi, Tabea Wilhelm, Heinz Kutzner, Carola Berking, Markus V. Heppt, Sebastian Haferkamp, Wiebke Sondermann, Dirk Schadendorf, Bastian Schilling, Benjamin Izar, Roman Maron, Max Schmitt, Stefan Fröhling, Stefan Fröhling, Daniel B. Lipka, Daniel B. Lipka, Daniel B. Lipka, Titus J. Brinker

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Bisulfite-free epigenomics and genomics of single cells through methylation-sensitive restriction by Christoph Niemöller, Julius Wehrle, Julian Riba, Rainer Claus, Nathalie Renz, Janika Rhein, Sabine Bleul, Juliane M. Stosch, Justus Duyster, Christoph Plass, Pavlo Lutsik, Daniel B. Lipka, Michael Lübbert, Heiko Becker

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Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia by Elliot Stieglitz, Tali Mazor, Adam B. Olshen, Huimin Geng, Laura C. Gelston, Jon Akutagawa, Daniel B. Lipka, Christoph Plass, Christian Flotho, Farid F. Chehab, Benjamin S. Braun, Joseph F. Costello, Mignon L. Loh

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S122: MUTANT IDH1 HIJACKS DIFFERENTIATION PROGRAMS IN MYELOID PROGENITOR CELLS TO IMPAIR GRANULOCYTIC DIFFERENTIATION. by Mariam Hakobyan, Jens Langstein, Emely Kleinert, Maximilian Schönung, Mark Hartmann, Hannah Rohdjess, Sina Staeble, Rainer Claus, Lars Bullinger, Christopher Oakes, Karsten Rippe, Stefan Fröhling, Stefan Pusch, Christoph Plass, Michael Milsom, Daniel B. Lipka

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A Phase Ib Dose-finding Study of Panobinostat and Ruxolitinib in Myelofibrosis by Claire Harrison, Florian H. Heidel, Alessandro M. Vannucchi, Jean-Jacques Kiladjian, Amjad Hayat, Francesco Passamonti, Eibhlin Conneally, Thomas Kindler, Bruno Martino, Daniel B. Lipka, Tommaso Stefanelli, Pantelia Roussou, Davide Germano, Jacqueline Ewan, Vincent Ribrag

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The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation by Ruth Meier, Gabriele Greve, Dennis Zimmer, Helena Bresser, Bettina Berberich, Ralitsa Langova, Julia Stomper, Anne Rubarth, Lars Feuerbach, Daniel B. Lipka, Joschka Hey, Björn Grüning, Benedikt Brors, Justus Duyster, Christoph Plass, Heiko Becker, Michael Lübbert

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Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells. by Ruth Merkle, Bernhard Steiert, Florian Salopiata, Sofia Depner, Andreas Raue, Nao Iwamoto, Max Schelker, Helge Hass, Marvin Wäsch, Martin E Böhm, Oliver Mücke, Daniel B Lipka, Christoph Plass, Wolf D Lehmann, Clemens Kreutz, Jens Timmer, Marcel Schilling, Ursula Klingmüller

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Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL by Justyna A. Wierzbinska, Reka Toth, Naveed Ishaque, Karsten Rippe, Jan-Philipp Mallm, Lara C. Klett, Daniel Mertens, Thorsten Zenz, Thomas Hielscher, Marc Seifert, Ralf Küppers, Yassen Assenov, Pavlo Lutsik, Stephan Stilgenbauer, Philipp M. Roessner, Martina Seiffert, John Byrd, Christopher C. Oakes, Christoph Plass, Daniel B. Lipka

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Integrating Patient Data Into Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review by Julia Höhn, Achim Hekler, Eva Krieghoff-Henning, Jakob Nikolas Kather, Jochen Sven Utikal, Friedegund Meier, Frank Friedrich Gellrich, Axel Hauschild, Lars French, Justin Gabriel Schlager, Kamran Ghoreschi, Tabea Wilhelm, Heinz Kutzner, Markus Heppt, Sebastian Haferkamp, Wiebke Sondermann, Dirk Schadendorf, Bastian Schilling, Roman C Maron, Max Schmitt, Tanja Jutzi, Stefan Fröhling, Daniel B Lipka, Titus Josef Brinker

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S120: MNX1-ACTIVATING ENHANCER HIJACKING EVENTS IN ACUTE MYELOID LEUKEMIA WITH DELETIONS ON CHROMOSOME 7Q by Anna Riedel, Justyna A. Wierzbińska, Umut H. Toprak, Aurore Touzart, Etienne Sollier, Simge Kelekçi, Katherine Kelly, Dieter Weichenhan, Anastasija Pejkovska, Ashish Goyal, Charlotte Meinen, Matthias Schlesner, Frank Westermann, Benedikt Brors, Lars Bullinger, Philipp Greif, Michael Lübbert, Florian Heidel, Thomas Fischer, Claudia Gebhard, Brigitte Schlegelberger, Gudrun Göhring, Yvonne Behrens, Ekaterina Jahn, Hartmut Döhner, Konstanze Döhner, Ruud Delwel, Pavlo Lutsik, Daniel B. Lipka, Christoph Plass

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Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p by Suzanne Faure-Dupuy, Tobias Riedl, Maude Rolland, Zoheir Hizir, Florian Reisinger, Katharina Neuhaus, Svenja Schuehle, Caroline Remouchamps, Nicolas Gillet, Maximilian Schönung, Mira Stadler, Jochen Wettengel, Romain Barnault, Romain Parent, Linda Christina Schuster, Rayan Farhat, Sandra Prokosch, Corinna Leuchtenberger, Rupert Öllinger, Thomas Engleitner, Karsten Rippe, Roland Rad, Kristian Unger, Darjus Tscharahganeh, Daniel B. Lipka, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwälder

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Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions by Julia Schöpf, Sebastian Uhrig, Christoph E. Heilig, Kwang-Seok Lee, Tatjana Walther, Alexander Carazzato, Anna Maria Dobberkau, Dieter Weichenhan, Christoph Plass, Mark Hartmann, Gaurav D. Diwan, Zunamys I. Carrero, Claudia R. Ball, Tobias Hohl, Thomas Kindler, Patricia Rudolph-Hähnel, Dominic Helm, Martin Schneider, Anna Nilsson, Ingrid Øra, Roland Imle, Ana Banito, Robert B. Russell, Barbara C. Jones, Daniel B. Lipka, Hanno Glimm, Daniel Hübschmann, Wolfgang Hartmann, Stefan Fröhling, Claudia Scholl

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MGMT inactivation as a new biomarker in patients with advanced biliary tract cancers by Monica Niger, Federico Nichetti, Andrea Casadei‐Gardini, Federica Morano, Chiara Pircher, Elena Tamborini, Federica Perrone, Matteo Canale, Daniel B. Lipka, Andrea Vingiani, Luca Agnelli, Anna Dobberkau, Jennifer Hüllein, Felix Korell, Christoph E. Heilig, Sara Pusceddu, Francesca Corti, Michele Droz, Paola Ulivi, Michele Prisciandaro, Maria Antista, Marta Bini, Laura Cattaneo, Massimo Milione, Hanno Glimm, Bruno C. Köhler, Giancarlo Pruneri, Daniel Hübschmann, Stefan Fröhling, Vincenzo Mazzaferro, Filippo Pietrantonio, Maria Di Bartolomeo, Filippo deBraud

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NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology by Andreas Mock, Maria-Veronica Teleanu, Simon Kreutzfeldt, Christoph E. Heilig, Jennifer Hüllein, Lino Möhrmann, Arne Jahn, Dorothea Hanf, Irina A. Kerle, Hans Martin Singh, Barbara Hutter, Sebastian Uhrig, Martina Fröhlich, Olaf Neumann, Andreas Hartig, Sascha Brückmann, Steffen Hirsch, Kerstin Grund, Nicola Dikow, Daniel B. Lipka, Marcus Renner, Irfan Ahmed Bhatti, Leonidas Apostolidis, Richard F. Schlenk, Christian P. Schaaf, Albrecht Stenzinger, Evelin Schröck, Daniel Hübschmann, Christoph Heining, Peter Horak, Hanno Glimm, Stefan Fröhling

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ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT by Mark Hartmann, Maximilian Schönung, Jovana Rajak, Joschka Hey, Valentin Maurer, Ling Hai, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Katrin M. Bernt, Roland Roelz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Michael D. Milsom, Stefan Fröhling, Marc-Jan Bonder, Charlotte Niemeyer, Christian Flotho, Christoph Plass, Miriam Erlacher, Matthias Schlesner, Daniel B. Lipka

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S206: ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT by Mark Hartmann, Maximilian Schönung, Jovana Rajak, Joschka Hey, Valentin Maurer, Ling Hai, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Kathrin Bernt, Roland Rölz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Michael Milsom, Stefan Fröhling, Marc-Jan Bonder, Christoph Plass, Charlotte Niemeyer, Christian Flotho, Miriam Erlacher, Matthias Schlesner, Daniel B. Lipka

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RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia by Daniel B. Lipka, Tania Witte, Reka Toth, Jing Yang, Manuel Wiesenfarth, Peter Nöllke, Alexandra Fischer, David Brocks, Zuguang Gu, Jeongbin Park, Brigitte Strahm, Marcin Wlodarski, Ayami Yoshimi, Rainer Claus, Michael Lübbert, Hauke Busch, Melanie Boerries, Mark Hartmann, Maximilian Schönung, Umut Kilik, Jens Langstein, Justyna A. Wierzbinska, Caroline Pabst, Swati Garg, Albert Catalá, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Owen Smith, Jan Stary, Marek Ussowicz, Marry M. van den Heuvel-Eibrink, Yassen Assenov, Matthias Schlesner, Charlotte Niemeyer, Christian Flotho, Christoph Plass

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Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity by Lino Möhrmann, Maximilian Werner, Małgorzata Oleś, Andreas Mock, Sebastian Uhrig, Arne Jahn, Simon Kreutzfeldt, Martina Fröhlich, Barbara Hutter, Nagarajan Paramasivam, Daniela Richter, Katja Beck, Ulrike Winter, Katrin Pfütze, Christoph E. Heilig, Veronica Teleanu, Daniel B. Lipka, Marc Zapatka, Dorothea Hanf, Catrin List, Michael Allgäuer, Roland Penzel, Gina Rüter, Ivan Jelas, Rainer Hamacher, Johanna Falkenhorst, Sebastian Wagner, Christian H. Brandts, Melanie Boerries, Anna L. Illert, Klaus H. Metzeler, C. Benedikt Westphalen, Alexander Desuki, Thomas Kindler, Gunnar Folprecht, Wilko Weichert, Benedikt Brors, Albrecht Stenzinger, Evelin Schröck, Daniel Hübschmann, Peter Horak, Christoph Heining, Stefan Fröhling, Hanno Glimm

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