Circulating tumor DNA: toward evolving the clinical paradigm of pancreatic ductal adenocarcinoma by James T. Topham, Daniel J. Renouf, David F. Schaeffer

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Advancing the Care of Pancreatic Cancer Patients: Moving Beyond Just Tumour Tissue by Steve E Kalloger, Joanna M Karasinska, Cassia Warren, Daniel J Renouf, David F Schaeffer

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Precision Oncology in Canada: Converting Vision to Reality with Lessons from International Programs by Geoffrey Liu, Winson Y. Cheung, Harriet Feilotter, Jackie Manthorne, Tracy Stockley, ManTek Yeung, Daniel J. Renouf

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Efficacy and Prognostic Factors for Y-90 Radioembolization (Y-90) in Metastatic Neuroendocrine Tumors with Liver Metastases by Erica S. Tsang, Jonathan M. Loree, Janine M. Davies, Sharlene Gill, David Liu, Stephen Ho, Daniel J. Renouf, Howard J. Lim, Hagen F. Kennecke

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Programmed cell death ligand 1 cut-point is associated with reduced disease specific survival in resected pancreatic ductal adenocarcinoma by Basile Tessier-Cloutier, Steve E. Kalloger, Mohammad Al-Kandari, Katy Milne, Dongxia Gao, Brad H. Nelson, Daniel J. Renouf, Brandon S. Sheffield, David F. Schaeffer

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Investigation of Nano-Bio Interactions within a Pancreatic Tumor Microenvironment for the Advancement of Nanomedicine in Cancer Treatment by Abdulaziz Alhussan, Kyle Bromma, Ece Pinar Demirci Bozdoğan, Andrew Metcalfe, Joanna Karasinska, Wayne Beckham, Abraham S. Alexander, Daniel J. Renouf, David F. Schaeffer, Devika B. Chithrani

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Matching methods in precision oncology: An introduction and illustrative example by Deirdre Weymann, Janessa Laskin, Steven J.M. Jones, Howard Lim, Daniel J. Renouf, Robyn Roscoe, Kasmintan A. Schrader, Sophie Sun, Stephen Yip, Marco A. Marra, Dean A. Regier

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TMBur: a distributable tumor mutation burden approach for whole genome sequencing by Emma Titmuss, Richard D. Corbett, Scott Davidson, Sanna Abbasi, Laura M. Williamson, Erin D. Pleasance, Adam Shlien, Daniel J. Renouf, Steven J. M. Jones, Janessa Laskin, Marco A. Marra

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Characterizing the G12C mutation in metastatic colorectal cancer: a population-based cohort and assessment of expression differences in The Cancer Genome Atlas by Meredith Li, Faeze Keshavarz-Rahaghi, Gale Ladua, Lucas Swanson, Caroline Speers, Daniel J. Renouf, Howard J. Lim, Janine M. Davies, Sharlene Gill, Heather C. Stuart, Stephen Yip, Jonathan M. Loree

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Exploration of Germline Correlates and Risk of Immune-Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors by Emma Titmuss, Irene S. Yu, Erin D. Pleasance, Laura M. Williamson, Karen Mungall, Andrew J. Mungall, Daniel J. Renouf, Richard Moore, Steven J. M. Jones, Marco A. Marra, Janessa J. Laskin, Kerry J. Savage

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Phase IB study of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors by Howard Streicher, Elad Sharon, Mariano Severgnini, Michael Manos, Anita Giobbie-Hurder, F Stephen Hodi, Andrew S Brohl, Philippe L Bedard, Kevin Tyan, Scott Rodig, Osama E Rahma, Daniel J Renouf, Emma Hathaway, Rachel Cunningham

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Whole-genome analysis of an aggressive metastatic pancreatic solid pseudopapillary neoplasm by Phoebe T. M. Cheng, James T. Topham, Ayman Aldeheshi, Gregory A. Taylor, Erin Pleasance, Melissa K. McConechy, Jessica M. T. Nelson, David F. Schaeffer, Steven J. M. Jones, Marco A. Marra, Janessa Laskin, Daniel J. Renouf

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Clinically impactful metabolic subtypes of pancreatic ductal adenocarcinoma (PDAC) by Jannat Pervin, Mohammad Asad, Shaolong Cao, Gun Ho Jang, Nikta Feizi, Benjamin Haibe-Kains, Joanna M. Karasinska, Grainne M. O’Kane, Steven Gallinger, David F. Schaeffer, Daniel J. Renouf, George Zogopoulos, Oliver F. Bathe, Oliver F. Bathe

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Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles by Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer

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Clinical and cost outcomes following genomics‐informed treatment for advanced cancers by Deirdre Weymann, Samantha Pollard, Brandon Chan, Emma Titmuss, Alexandra Bohm, Janessa Laskin, Steven J. M. Jones, Erin Pleasance, Jessica Nelson, Alexandra Fok, Howard Lim, Aly Karsan, Daniel J. Renouf, Kasmintan A. Schrader, Sophie Sun, Stephen Yip, David F. Schaeffer, Marco A. Marra, Dean A. Regier

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Optimizing the number of variants tracked to follow disease burden with circulating tumor DNA assays in metastatic colorectal cancer by Mélina Boutin, James T. Topham, Harriet Feilotter, Hagen F. Kennecke, Félix Couture, Mohammed Harb, Peter Kavan, Scott Berry, Howard J. Lim, John R. Goffin, Chaudhary Ahmad, Anthony Lott, Daniel J. Renouf, Derek J. Jonker, Dongsheng Tu, Chris J. O’Callaghan, Eric X. Chen, Jonathan M. Loree

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Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities by Yuka Takemon, Erin D. Pleasance, Alessia Gagliardi, Christopher S. Hughes, Veronika Csizmok, Kathleen Wee, Diane L. Trinh, Ryan D. Huff, Andrew J. Mungall, Richard A. Moore, Eric Chuah, Karen L. Mungall, Eleanor Lewis, Jessica Nelson, Howard J. Lim, Daniel J. Renouf, Steven JM. Jones, Janessa Laskin, Marco A. Marra

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Current Role of Immunotherapy in Gastric, Esophageal and Gastro-Esophageal Junction Cancers—A Report from the Western Canadian Gastrointestinal Cancer Consensus Conference by Karen Mulder, Howard Lim, Deepti Ravi, Shahida Ahmed, Bryan Brunet, Janine Davies, Corinne Doll, Dorie-Anna Dueck, Vallerie Gordon, Pamela Hebbard, Christina A. Kim, Duc Le, Richard Lee-Ying, John Paul McGhie, Jason Park, Daniel J. Renouf, Devin Schellenberg, Ralph P. W. Wong, Adnan Zaidi, Shahid Ahmed

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Systemic Therapy and Its Surgical Implications in Patients with Resectable Liver Colorectal Cancer Metastases. A Report from the Western Canadian Gastrointestinal Cancer Consensus... by Shahid Ahmed, Nicholas Bosma, Michael Moser, Shahida Ahmed, Bryan Brunet, Janine Davies, Corinne Doll, Dorie-Anna Dueck, Christina A. Kim, Shuying Ji, Duc Le, Richard Lee-Ying, Howard Lim, John Paul McGhie, Karen Mulder, Jason Park, Deepti Ravi, Daniel J. Renouf, Devin Schellenberg, Ralph P. W. Wong, Adnan Zaidi

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Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration by Erica S. Tsang, Veronika Csizmok, Laura M. Williamson, Erin Pleasance, James T. Topham, Joanna M. Karasinska, Emma Titmuss, Intan Schrader, Stephen Yip, Basile Tessier-Cloutier, Karen Mungall, Tony Ng, Sophie Sun, Howard J. Lim, Jonathan M. Loree, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, David F. Schaeffer, Daniel J. Renouf

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