Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised “Two-Hit” Hypothesis by Genta Kakiyama, Daniel Rodriguez-Agudo, William M. Pandak

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Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation* by Daniel Rodriguez-Agudo, Shunlin Ren, Eric Wong, Dalila Marques, Kaye Redford, Gregorio Gil, Phillip Hylemon, William M. Pandak

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Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate. by Shunlin Ren, Jin Koung Kim, Genta Kakiyama, Daniel Rodriguez-Agudo, William M Pandak, Hae-Ki Min, Yanxia Ning

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Identification of a novel sulfonated oxysterol, 5-cholesten-3β,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria by Shunlin Ren, Phillip Hylemon, Zong-Ping Zhang, Daniel Rodriguez-Agudo, Dalila Marques, Xiaobo Li, Huiping Zhou, Gregorio Gil, William M. Pandak

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Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease by Kei Minowa, Daniel Rodriguez-Agudo, Mitsuyoshi Suzuki, Yamato Muto, Saeko Hirai, Yaping Wang, Lianyong Su, Huiping Zhou, Qun Chen, Edward J. Lesnefsky, Kuniko Mitamura, Shigeo Ikegawa, Hajime Takei, Hiroshi Nittono, Michael Fuchs, William M. Pandak, Genta Kakiyama

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Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition by Genta Kakiyama, Dalila Marques, Rebecca Martin, Hajime Takei, Daniel Rodriguez-Agudo, Sandra A. LaSalle, Taishi Hashiguchi, Xiaoying Liu, Richard Green, Sandra Erickson, Gregorio Gil, Michael Fuchs, Mitsuyoshi Suzuki, Tsuyoshi Murai, Hiroshi Nittono, Phillip B. Hylemon, Huiping Zhou, William M. Pandak

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