BH3 Mimetics for the Treatment of B-Cell Malignancies—Insights and Lessons from the Clinic by Victor S. Lin, Zhuo-Fan Xu, David C. S. Huang, Rachel Thijssen

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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. by Mark S Cragg, Junya Kuroda, Hamsa Puthalakath, David C S Huang, Andreas Strasser

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Current Advances and Future Strategies for BCL-2 Inhibitors: Potent Weapons against Cancers by Jiaxuan Xu, Xiaoqing Dong, David C. S. Huang, Peipei Xu, Quan Zhao, Bing Chen

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Co-operation of MCL-1 and BCL-XL anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity by Daria Galas-Filipowicz, Selina J. Chavda, Jia-Nan Gong, Jia-Nan Gong, David C. S. Huang, Asim Khwaja, Kwee Yong

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Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1. by Marc Kvansakul, Andrew H Wei, Jamie I Fletcher, Simon N Willis, Lin Chen, Andrew W Roberts, David C S Huang, Peter M Colman

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A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation. by Christina B Wölwer, Luke B Pase, Helen B Pearson, Nathan J Gödde, Kurt Lackovic, David C S Huang, Sarah M Russell, Patrick O Humbert

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Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. by Megumi Takiguchi, Lukas E Dow, Julia E Prier, Catherine L Carmichael, Benjamin T Kile, Stephen J Turner, Scott W Lowe, David C S Huang, Ross A Dickins

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BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming by Esther J.Y. Kim, Minna-Liisa Anko, Christoffer Flensberg, Ian J. Majewski, Fan-Suo Geng, Jaber Firas, David C.S. Huang, Mark F. van Delft, Joan K. Heath

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Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells by Liz J. Valente, Brandon J. Aubrey, Marco J. Herold, Gemma L. Kelly, Lina Happo, Clare L. Scott, Andrea Newbold, Ricky W. Johnstone, David C.S. Huang, Lyubomir T. Vassilev, Andreas Strasser

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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection by V. Pragathi Masamsetti, Ronnie Ren Jie Low, Ka Sin Mak, Aisling O’Connor, Chris D. Riffkin, Noa Lamm, Laure Crabbe, Jan Karlseder, David C. S. Huang, Makoto T. Hayashi, Anthony J. Cesare

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Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations by Richard W. Birkinshaw, Jia-nan Gong, Cindy S. Luo, Daisy Lio, Christine A. White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C. S. Huang, Peter M. Colman, Peter E. Czabotar

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Mesenchymal stromal cell apoptosis is required for their therapeutic function by Swee Heng Milon Pang, Joshua D’Rozario, Senora Mendonca, Tejasvini Bhuvan, Natalie L. Payne, Di Zheng, Assifa Hisana, Georgia Wallis, Adele Barugahare, David Powell, Jai Rautela, Nicholas D. Huntington, Grant Dewson, David C. S. Huang, Daniel H. D. Gray, Tracy S. P. Heng

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The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL by Annette V. Jacobsen, Catia L. Pierotti, Kym N. Lowes, Amanda E. Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus J. A. Kersten, André L. Samson, Mark F. van Delft, David C. S. Huang, Hélène Jousset Sabroux, Guillaume Lessene, John Silke, James M. Murphy

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The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer by Xiangwei Zeng, Bing Yao, Jianpeng Liu, Guan-Wen Gong, Ming Liu, Jiahuang Li, Hua-Feng Pan, Qixiang Li, Dongjun Yang, Peifen Lu, Dongliang Wu, Peipei Xu, Bing Chen, Panhai Chen, Ming Zhang, Ke Zen, Jian Jing, David C. S. Huang, Dijun Chen, Zhi-Wei Jiang, Quan Zhao

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Correction to: PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling by Bing Yao, Tao Gui, Xiangwei Zeng, Yexuan Deng, Zhi Wang, Ying Wang, Dongjun Yang, Qixiang Li, Peipei Xu, Ruifeng Hu, Xinyu Li, Bing Chen, Jin Wang, Ke Zen, Haitao Li, Melissa J. Davis, Marco J. Herold, Hua-Feng Pan, Zhi-Wei Jiang, David C. S. Huang, Ming Liu, Junyi Ju, Quan Zhao

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PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling by Bing Yao, Tao Gui, Xiangwei Zeng, Yexuan Deng, Zhi Wang, Ying Wang, Dongjun Yang, Qixiang Li, Peipei Xu, Ruifeng Hu, Xinyu Li, Bing Chen, Jin Wang, Ke Zen, Haitao Li, Melissa J. Davis, Marco J. Herold, Hua-Feng Pan, Zhi-Wei Jiang, David C. S. Huang, Ming Liu, Junyi Ju, Quan Zhao

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NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression by Junyi Ju, Aiping Chen, Yexuan Deng, Ming Liu, Ying Wang, Yadong Wang, Min Nie, Chao Wang, Hong Ding, Bing Yao, Tao Gui, Xinyu Li, Zhen Xu, Chi Ma, Yong Song, Marc Kvansakul, Ke Zen, Chen-Yu Zhang, Cheng Luo, Ming Fang, David C. S. Huang, C. David Allis, Renxiang Tan, Changjiang Kathy Zeng, Jiwu Wei, Quan Zhao

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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth by Tsz-Yin Chan, Christina M. Egbert, Julia E. Maxson, Adam Siddiqui, Logan J. Larsen, Kristina Kohler, Eranga Roshan Balasooriya, Katie L. Pennington, Tsz-Ming Tsang, Madison Frey, Erik J. Soderblom, Huimin Geng, Markus Müschen, Tetyana V. Forostyan, Savannah Free, Gaelle Mercenne, Courtney J. Banks, Jonard Valdoz, Clifford J. Whatcott, Jason M. Foulks, David J. Bearss, Thomas O’Hare, David C. S. Huang, Kenneth A. Christensen, James Moody, Steven L. Warner, Jeffrey W. Tyner, Joshua L. Andersen

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Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing by Luyi Tian, Jafar S. Jabbari, Rachel Thijssen, Quentin Gouil, Shanika L. Amarasinghe, Oliver Voogd, Hasaru Kariyawasam, Mei R. M. Du, Jakob Schuster, Changqing Wang, Shian Su, Xueyi Dong, Charity W. Law, Alexis Lucattini, Yair David Joseph Prawer, Coralina Collar-Fernández, Jin D. Chung, Timur Naim, Audrey Chan, Chi Hai Ly, Gordon S. Lynch, James G. Ryall, Casey J. A. Anttila, Hongke Peng, Mary Ann Anderson, Christoffer Flensburg, Ian Majewski, Andrew W. Roberts, David C. S. Huang, Michael B. Clark, Matthew E. Ritchie

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