David A. Sinclair

Sinclair in 2020 David Andrew Sinclair (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard. He is the co-author of ''Lifespan: Why We Age – and Why We Don't Have To.'' Provided by Wikipedia
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  1. 1
    Head to head comparison of short-term treatment with the NAD+ precursor nicotinamide mononucleotide (NMN) and six weeks of exercise in obese female mice

    Head to head comparison of short-term treatment with the NAD+ precursor nicotinamide mononucleotide (NMN) and six weeks of exercise in obese female mice by Golam Mezbah Uddin, Neil A Youngson, David A Sinclair, David A Sinclair, Margaret J Morris

    Published 2016-08-01
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  2. 2
    Can artificial intelligence identify effective COVID‐19 therapies?

    Can artificial intelligence identify effective COVID‐19 therapies? by Michael B Schultz, Daniel Vera, David A Sinclair

    Published 2020-07-01
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  3. 3
    MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

    MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. by Oliver Medvedik, Dudley W Lamming, Keyman D Kim, David A Sinclair

    Published 2007-10-01
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  4. 4
    Novel feature selection methods for construction of accurate epigenetic clocks.

    Novel feature selection methods for construction of accurate epigenetic clocks. by Adam Li, Amber Mueller, Brad English, Anthony Arena, Daniel Vera, Alice E Kane, David A Sinclair

    Published 2022-08-01
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  5. 5
    Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers

    Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers by Golam M. Uddin, Neil A. Youngson, Sabiha S. Chowdhury, Christopher Hagan, David A. Sinclair, Margaret J. Morris

    Published 2020-03-01
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  6. 6
    The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice

    The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice by Qing-Shuo Zhang, Matthew Deater, Kathryn Schubert, Laura Marquez-Loza, Carl Pelz, David A. Sinclair, Markus Grompe

    Published 2015-07-01
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  7. 7
    Sex dimorphism and tissue specificity of gene expression changes in aging mice

    Sex dimorphism and tissue specificity of gene expression changes in aging mice by Dantong Zhu, Matt Arnold, Brady A. Samuelson, Judy Z. Wu, Amber Mueller, David A. Sinclair, Alice E. Kane

    Published 2024-10-01
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  8. 8
    Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung

    Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung by Pierre Montay-Gruel, Yafeng Zhu, Benoit Petit, Ron Leavitt, Mike Warn, Erich Giedzinski, Jonathan Ollivier, David A. Sinclair, Marie-Catherine Vozenin, Charles L. Limoli

    Published 2021-03-01
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  9. 9
    Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila

    Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila by Justin A Bosch, Berrak Ugur, Israel Pichardo-Casas, Jordan Rabasco, Felipe Escobedo, Zhongyuan Zuo, Ben Brown, Susan Celniker, David A Sinclair, Hugo J Bellen, Norbert Perrimon

    Published 2022-11-01
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  10. 10
    Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

    Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells by Pauline Rimmelé, Carolina L. Bigarella, Raymond Liang, Brigitte Izac, Rebeca Dieguez-Gonzalez, Gaetan Barbet, Michael Donovan, Carlo Brugnara, Julie M. Blander, David A. Sinclair, Saghi Ghaffari

    Published 2014-07-01
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  11. 11
    Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty

    Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty by Michael B. Schultz, Alice E. Kane, Sarah J. Mitchell, Michael R. MacArthur, Elisa Warner, David S. Vogel, James R. Mitchell, Susan E. Howlett, Michael S. Bonkowski, David A. Sinclair

    Published 2020-10-01
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  12. 12
    Age and life expectancy clocks based on machine learning analysis of mouse frailty

    Age and life expectancy clocks based on machine learning analysis of mouse frailty by Michael B. Schultz, Alice E. Kane, Sarah J. Mitchell, Michael R. MacArthur, Elisa Warner, David S. Vogel, James R. Mitchell, Susan E. Howlett, Michael S. Bonkowski, David A. Sinclair

    Published 2020-09-01
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  13. 13
    NMN Supplementation Rescues Fertility and Bone Strength in Chemotherapy-Treated Mice

    NMN Supplementation Rescues Fertility and Bone Strength in Chemotherapy-Treated Mice by Maria B. MARINOVA, Wing-Hong Jonathan HO, Michael J. BERTOLDO, Vedran LOVRIC, Kaisa SELESNIEMI, William R. WALSH, David A. SINCLAIR, Kirsty WALTERS, Robert B. GILCHRIST, Lindsay E. WU

    Published 2022-09-01
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  14. 14
    JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

    JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks by Michael Van Meter, Matthew Simon, Gregory Tombline, Alfred May, Timothy D. Morello, Basil P. Hubbard, Katie Bredbenner, Rosa Park, David A. Sinclair, Vilhelm A. Bohr, Vera Gorbunova, Andrei Seluanov

    Published 2016-09-01
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  15. 15
    Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy.

    Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. by Shaday Michan, Aimee M Juan, Christian G Hurst, Zhenghao Cui, Lucy P Evans, Colman J Hatton, Dorothy T Pei, Meihua Ju, David A Sinclair, Lois E H Smith, Jing Chen

    Published 2014-01-01
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  16. 16
    The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

    The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. by Ron Firestein, Gil Blander, Shaday Michan, Philipp Oberdoerffer, Shuji Ogino, Jennifer Campbell, Anupama Bhimavarapu, Sandra Luikenhuis, Rafael de Cabo, Charles Fuchs, William C Hahn, Leonard P Guarente, David A Sinclair

    Published 2008-04-01
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  17. 17
    Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

    Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mic... by Stefano Tarantini, Marta Noa Valcarcel-Ares, Peter Toth, Andriy Yabluchanskiy, Zsuzsanna Tucsek, Tamas Kiss, Peter Hertelendy, Michael Kinter, Praveen Ballabh, Zoltán Süle, Eszter Farkas, Joseph A. Baur, David A. Sinclair, Anna Csiszar, Zoltan Ungvari

    Published 2019-06-01
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  18. 18
    Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer‐based precipitation and size exclusion chromatography

    Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer‐based precipitation and size exclusion chromatography by Juan A. Martínez‐Greene, Karina Hernández‐Ortega, Ricardo Quiroz‐Baez, Osbaldo Resendis‐Antonio, Israel Pichardo‐Casas, David A. Sinclair, Bogdan Budnik, Alfredo Hidalgo‐Miranda, Eileen Uribe‐Querol, María del Pilar Ramos‐Godínez, Eduardo Martínez‐Martínez

    Published 2021-04-01
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  19. 19
    Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage

    Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage by Emma Bolderson, Joshua T. Burgess, Jun Li, Neha S. Gandhi, Didier Boucher, Laura V. Croft, Samuel Beard, Jennifer J. Plowman, Amila Suraweera, Mark N. Adams, Ali Naqi, Shu-Dong Zhang, David A. Sinclair, Kenneth J. O’Byrne, Derek J. Richard

    Published 2019-12-01
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  20. 20
    Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice

    Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice by Sara Santos Franco, Luigia De Falco, Saghi Ghaffari, Carlo Brugnara, David A. Sinclair, Alessandro Matte’, Achille Iolascon, Narla Mohandas, Mariarita Bertoldi, Xiuli An, Angela Siciliano, Pauline Rimmelé, Maria Domenica Cappellini, Shaday Michan, Elisa Zoratti, Janin Anne, Lucia De Franceschi

    Published 2014-02-01
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