David Holcman
David Holcman is an applied mathematician, biophysicist and computational biologist at École Normale Supérieure in Paris. He is known for his work on the narrow escape problem, based on analysis of the Laplace equation, the redundancy principle in biology based on extreme statistics, the modeling of molecular trafficking in neurobiology, of diffusion and electrodiffusion in nanodomains such as dendritic spines, the modeling of neuronal networks dynamics such as Up and Down states in electrophysiology. He developed multiscale methods and simulations to analyse large amount of molecular super-resolution trajectories, and polymer physics modeling and analysis to study cell nucleus organization. These computational approaches led to several verified predictions in the life sciences such as nanocolumn organization of synapses or astrocytic protrusion penetrating neuronal synapses, molecular ER organization in dendritic spines and many more. The narrow escape theory was recently verified in physical experiments. Provided by Wikipedia
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Escape from an attractor generated by recurrent exit by Lou Zonca, David Holcman
Published 2021-05-01
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Adaptive Single-Channel EEG Artifact Removal With Applications to Clinical Monitoring by Matteo Dora, David Holcman
Published 2022-01-01
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Dynamic Regulation of Mitochondrial [Ca<sup>2+</sup>] in Hippocampal Neurons by Liliya Kushnireva, Kanishka Basnayake, David Holcman, Menahem Segal, Eduard Korkotian
Published 2022-10-01
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Experiments in micro-patterned model membranes support the narrow escape theory by Elisabeth Meiser, Reza Mohammadi, Nicolas Vogel, David Holcman, Susanne F. Fenz
Published 2023-11-01
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Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning by Yassine X Bouchoucha, Jürgen Reingruber, Charlotte Labalette, Michel A Wassef, Elodie Thierion, Carole Desmarquet‐Trin Dinh, David Holcman, Pascale Gilardi‐Hebenstreit, Patrick Charnay
Published 2013-01-01
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Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles by Shanley F. Longfield, Rachel S. Gormal, Matis Feller, Pierre Parutto, Jürgen Reingruber, Tristan P. Wallis, Merja Joensuu, George J. Augustine, Ramón Martínez-Mármol, David Holcman, Frédéric A. Meunier
Published 2024-03-01
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Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries by Li-Hsin Chang, Sourav Ghosh, Andrea Papale, Jennifer M. Luppino, Mélanie Miranda, Vincent Piras, Jéril Degrouard, Joanne Edouard, Mallory Poncelet, Nathan Lecouvreur, Sébastien Bloyer, Amélie Leforestier, Eric F. Joyce, David Holcman, Daan Noordermeer
Published 2023-09-01
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Predicting neurological outcome after cardiac arrest by combining computational parameters extracted from standard and deviant responses from auditory evoked potentials by Aymeric Floyrac, Adrien Doumergue, Stéphane Legriel, Stéphane Legriel, Nicolas Deye, Nicolas Deye, Bruno Megarbane, Bruno Megarbane, Alexandra Richard, Elodie Meppiel, Sana Masmoudi, Pierre Lozeron, Pierre Lozeron, Eric Vicaut, Nathalie Kubis, Nathalie Kubis, David Holcman
Published 2023-02-01
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