Soluble urokinase plasminogen activator receptor: from biomarker to active participant in atherosclerosis and cardiovascular disease by Traci T. Goodchild, Zhen Li, David J. Lefer

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Hydrogen Sulfide Levels and Nuclear Factor‐Erythroid 2‐Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI) by Kazi N. Islam, David J. Polhemus, Erminia Donnarumma, Luke P. Brewster, David J. Lefer

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364 Beneficial Actions of SGLT2 Inhibition and H2S Therapy in Heart Failure with Preserved Ejection Fraction by Jake Doiron, Zhen Li, Huijing Xia, Kyle B. Lapenna, Timothy D. Allerton, Daniel R. Kapusta, David J. Lefer

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Hydrogen Sulfide as a Potential Therapy for Heart Failure—Past, Present, and Future by Kyle B. LaPenna, David J. Polhemus, Jake E. Doiron, Hunter A. Hidalgo, Zhen Li, David J. Lefer

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Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure by Erminia Donnarumma, Shashi Bhushan, Jessica M. Bradley, Hiroyuki Otsuka, Erinn L. Donnelly, David J. Lefer, Kazi N. Islam

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Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice. by Yuling Chi, Jean-Francois Jasmin, Yoshinori Seki, Michael P Lisanti, Maureen J Charron, David J Lefer, Victor L Schuster

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Combined Angiotensin Receptor–Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure by Rishi K. Trivedi, David J. Polhemus, Zhen Li, Daniel Yoo, Hiroshi Koiwaya, Amy Scarborough, Traci T. Goodchild, David J. Lefer

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PO-20 A HYDROGEN SULFIDE PRODRUG AUGMENTS ANGIOGENESIS IN A SWINE MODEL OF CRITICAL LIMB ISCHEMIA VIA A NITRIC OXIDE DEPENDENT MECHANISM by Amanda M. Rushing, Amy L. Scarborough, Sarah F. Boisvert, Erminia Donnarumma, Rishi Trivedi, David J. Polhemus, David J. Lefer, Traci T. Goodchild

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Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction by Sumit Kar, Hamid R. Shahshahan, Tyler N. Kambis, Santosh K. Yadav, Zhen Li, David J. Lefer, Paras K. Mishra, Paras K. Mishra

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Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure by Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer

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Endothelial Cell Cystathionine γ‐Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury by Huijing Xia, Zhen Li, Thomas E. Sharp, David J. Polhemus, Jean Carnal, Karl H. Moles, Ya‐Xiong Tao, John Elrod, Josef Pfeilschifter, Karl‐Friedrich Beck, David J. Lefer

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Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics by Axel J. Fenwick, Vivek P. Jani, D. Brian Foster, Thomas E. Sharp, Traci T. Goodchild, Kyle LaPenna, Jake E. Doiron, David J. Lefer, Joseph A. Hill, David A. Kass, Anthony Cammarato

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Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction by Jake E. Doiron, Zhen Li, Xiaoman Yu, Kyle B. LaPenna, Heather Quiriarte, Timothy D. Allerton, Kashyap Koul, Andrew Malek, Sanjiv J. Shah, Thomas E. Sharp, Traci T. Goodchild, Daniel R. Kapusta, David J. Lefer

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Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a “2‐Hit” Murine Model by Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, David J. Lefer

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Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability by Erminia Donnarumma, Murtuza J. Ali, Amanda M. Rushing, Amy L. Scarborough, Jessica M. Bradley, Chelsea L. Organ, Kazi N. Islam, David J. Polhemus, Stefano Evangelista, Giuseppe Cirino, J. Stephen Jenkins, Rajan A. G. Patel, David J. Lefer, Traci T. Goodchild

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Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop by Amrita Ahluwalia, Mark Gladwin, Gary D. Coleman, Norman Hord, George Howard, Daniel B. Kim‐Shapiro, Martin Lajous, Filip J. Larsen, David J. Lefer, Leslie A. McClure, Bernard T. Nolan, Ryszard Pluta, Alan Schechter, Chia‐Yih Wang, Mary H. Ward, Jane L. Harman

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Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure by Zhen Li, BS, Chelsea L. Organ, PhD, Jianming Kang, PhD, David J. Polhemus, PhD, Rishi K. Trivedi, PhD, Thomas E. Sharp, III, PhD, Jack S. Jenkins, Ya-xiong Tao, PhD, Ming Xian, PhD, David J. Lefer, PhD

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