The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and Diagnostics by Edward Weaver, Shahid Uddin, David K. Cole, Andrew Hooker, Dimitrios A. Lamprou

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In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility by Christopher J. Holland, Christopher J. Holland, Bruce J. MacLachlan, Valentina Bianchi, Valentina Bianchi, Sophie J. Hesketh, Sophie J. Hesketh, Richard Morgan, Owen Vickery, Anna M. Bulek, Anna Fuller, Andrew Godkin, Andrew K. Sewell, Pierre J. Rizkallah, Stephen Wells, David K. Cole, David K. Cole

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Peptide Super-Agonist Enhances T-Cell Responses to Melanoma by Sarah A. E. Galloway, Garry Dolton, Meriem Attaf, Aaron Wall, Anna Fuller, Cristina Rius, Valentina Bianchi, Sarah Theaker, Angharad Lloyd, Angharad Lloyd, Marine E. Caillaud, Inge Marie Svane, Marco Donia, David K. Cole, David K. Cole, Barbara Szomolay, Pierre Rizkallah, Andrew K. Sewell, Andrew K. Sewell

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Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions by Alexander T. Baker, Alexander Greenshields-Watson, Lynda Coughlan, James A. Davies, Hanni Uusi-Kerttula, David K. Cole, Pierre J. Rizkallah, Alan L. Parker

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Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation by Nicholas Jones, James G. Cronin, Garry Dolton, Silvia Panetti, Andrea J. Schauenburg, Sarah A. E. Galloway, Andrew K. Sewell, David K. Cole, Catherine A. Thornton, Nigel J. Francis

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Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy by Rory M. Crean, Bruce J. MacLachlan, Florian Madura, Thomas Whalley, Pierre J. Rizkallah, Christopher J. Holland, Catriona McMurran, Stephen Harper, Andrew Godkin, Andrew K. Sewell, Christopher R. Pudney, Marc W. van der Kamp, David K. Cole

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Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation by Anna-Lisa Lanz, Giulia Masi, Nicla Porciello, André Cohnen, Deborah Cipria, Dheeraj Prakaash, Štefan Bálint, Roberto Raggiaschi, Donatella Galgano, David K. Cole, Marco Lepore, Omer Dushek, Michael L. Dustin, Mark S.P. Sansom, Antreas C. Kalli, Oreste Acuto

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Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. by John J Miles, Anna M Bulek, David K Cole, Emma Gostick, Andrea J A Schauenburg, Garry Dolton, Vanessa Venturi, Miles P Davenport, Mai Ping Tan, Scott R Burrows, Linda Wooldridge, David A Price, Pierre J Rizkallah, Andrew K Sewell

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897-C TROCEPT tumor-specific targeting and replication enables in-tumor production of immune checkpoint inhibitors following intravenous delivery by Andrew B Gerry, Bent K Jakobsen, David Krige, Rahul C Khanolkar, James A Davies, Alexander T Baker, Thomas A Webb, Alicia Teijeira-Crespo, Hanni K Uusi-Kerttula, Lucy M Williams, Samantha L Moore, Johanne M Pentier, Alan L Parker, David K Cole

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation by Hugo Antonius van den Berg, Kristin eLadell, Kelly eMiners, Bruno eLaugel, Sian eLlewellyn-Lacey, Mathew eClement, David K Cole, Emma eGostick, Linda eWooldridge, Andrew Kelvin Sewell, John Stephen Bridgeman, David A Price, David A Price

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GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope by Thomas Whalley, Thomas Whalley, Garry Dolton, Paul E. Brown, Aaron Wall, Linda Wooldridge, Hugo van den Berg, Anna Fuller, Jade R. Hopkins, Michael D. Crowther, Meriem Attaf, Robin R. Knight, David K. Cole, Mark Peakman, Andrew K. Sewell, Andrew K. Sewell, Barbara Szomolay, Barbara Szomolay

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Development of a low-seroprevalence, αvβ6 integrin-selective virotherapy based on human adenovirus type 10 by Emily A. Bates, James A. Davies, Jana Váňová, Davor Nestić, Valerie S. Meniel, Sarah Koushyar, Tabitha G. Cunliffe, Rosie M. Mundy, Elise Moses, Hanni K. Uusi-Kerttula, Alexander T. Baker, David K. Cole, Dragomira Majhen, Pierre J. Rizkallah, Toby Phesse, John D. Chester, Alan L. Parker

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Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope by David K. Cole, Anna Fuller, Garry Dolton, Efthalia Zervoudi, Mateusz Legut, Kim Miles, Lori Blanchfield, Florian Madura, Christopher J. Holland, Anna M. Bulek, John S. Bridgeman, John J. Miles, John J. Miles, Andrea J. A. Schauenburg, Konrad Beck, Brian D. Evavold, Pierre J. Rizkallah, Andrew K. Sewell

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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen by Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N. Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D. Dukes, Nathaniel Liddy, Marc Van der Kamp, Gregory D. Plowman, Annelise Vuidepot, David K. Cole, Andrew D. Whale, Chandramouli Chillakuri

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CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features by Alexander Greenshields-Watson, Meriem Attaf, Bruce J. MacLachlan, Thomas Whalley, Cristina Rius, Aaron Wall, Angharad Lloyd, Hywel Hughes, Kathryn E. Strange, Georgina H. Mason, Andrea J. Schauenburg, Sarah L. Hulin-Curtis, James Geary, Yuan Chen, Sarah N. Lauder, Kathryn Smart, Dhanasekaran Vijaykrishna, Miguel L. Grau, Mikhail Shugay, Robert Andrews, Garry Dolton, Pierre J. Rizkallah, Awen M. Gallimore, Andrew K. Sewell, Andrew J. Godkin, David K. Cole

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