Predictably unequal: understanding and addressing concerns that algorithmic clinical prediction may increase health disparities by Jessica K. Paulus, David M. Kent

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391 Value estimation of the Diabetes Prevention Program: How well does clinical trial-based cost-effectiveness apply to the real world? by Natalia Olchanski, Samuel B. Weidner, Joshua T. Cohen, David M. Kent

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Estimating individualized treatment effects from randomized controlled trials: a simulation study to compare risk-based approaches by Alexandros Rekkas, Peter R. Rijnbeek, David M. Kent, Ewout W. Steyerberg, David van Klaveren

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3385 TARGETING DIABETES PREVENTION PROGRAMS: INDIVIDUAL RISK-BASED HEALTH ECONOMIC ANALYSIS by Natalia Olchanski, David van Klaveren, Joshua T Cohen, John B Wong, Robin Ruthazer, David M Kent

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A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases by Alexandros Rekkas, David van Klaveren, Patrick B. Ryan, Ewout W. Steyerberg, David M. Kent, Peter R. Rijnbeek

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Developing a cancer‐specific trigger tool to identify treatment‐related adverse events using administrative data by Saul N. Weingart, Jason Nelson, Benjamin Koethe, Omar Yaghi, Stephan Dunning, Albert Feldman, David M. Kent, Allison Lipitz‐Snyderman

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A Clinical Model to Predict the Occurrence of Select High-risk Infections in the First Year Following Heart Transplantation by Whitney A. Perry, MD, MS, Jennifer K. Chow, MD, MS, Jason Nelson, MPH, David M. Kent, MD, MS, David R. Snydman, MD

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Statins are rarely prescribed for incidentally discovered covert cerebrovascular disease: a retrospective cohort in a large electronic health record (EHR) identified using natural... by David F Kallmes, David M Kent, Hongfang Liu, Lester Y Leung, Wansu Chen, Eric Puttock, Patrick Luetmer, Sunyang Fu, Chengyi X Zheng

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Association of Incidentally Discovered Covert Cerebrovascular Disease Identified Using Natural Language Processing and Future Dementia by David M. Kent, Lester Y. Leung, Yichen Zhou, Patrick H. Luetmer, David F. Kallmes, Jason Nelson, Sunyang Fu, Eric J. Puttock, Chengyi Zheng, Hongfang Liu, Wansu Chen

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Stakeholder engagement in methodological research: Development of a clinical decision support tool by Denise H. Daudelin, Robin Ruthazer, Manlik Kwong, Rebecca C. Lorenzana, Daniel J. Hannon, David M. Kent, Timothy E. McAlindon, Norma Terrin, John B. Wong, Harry P. Selker

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Treatment effect modification due to comorbidity: Individual participant data meta-analyses of 120 randomised controlled trials by Peter Hanlon, Elaine W. Butterly, Anoop SV Shah, Laurie J. Hannigan, Jim Lewsey, Frances S. Mair, David M. Kent, Bruce Guthrie, Sarah H. Wild, Nicky J. Welton, Sofia Dias, David A. McAllister

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Treatment effect modification due to comorbidity: Individual participant data meta-analyses of 120 randomised controlled trials. by Peter Hanlon, Elaine W Butterly, Anoop Sv Shah, Laurie J Hannigan, Jim Lewsey, Frances S Mair, David M Kent, Bruce Guthrie, Sarah H Wild, Nicky J Welton, Sofia Dias, David A McAllister

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Guidance for unbiased predictive information for healthcare decision-making and equity (GUIDE): considerations when race may be a prognostic factor by Keren Ladin, John Cuddeback, O. Kenrik Duru, Sharad Goel, William Harvey, Jinny G. Park, Jessica K. Paulus, Joyce Sackey, Richard Sharp, Ewout Steyerberg, Berk Ustun, David van Klaveren, Saul N. Weingart, David M. Kent

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Prognostic models for COVID-19 needed updating to warrant transportability over time and space by David van Klaveren, Theodoros P. Zanos, Jason Nelson, Todd J. Levy, Jinny G. Park, Isabel R. A. Retel Helmrich, Judith A. C. Rietjens, Melissa J. Basile, Negin Hajizadeh, Hester F. Lingsma, David M. Kent

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Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis. by Elaine W Butterly, Peter Hanlon, Anoop S V Shah, Laurie J Hannigan, Emma McIntosh, Jim Lewsey, Sarah H Wild, Bruce Guthrie, Frances S Mair, David M Kent, Sofia Dias, Nicky J Welton, David A McAllister

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Integrated care in patients with atrial fibrillation- a predictive heterogeneous treatment effect analysis of the ALL-IN trial. by Emmy M Trinks-Roerdink, Geert-Jan Geersing, Carline J van den Dries, Martin E W Hemels, Michiel Rienstra, Isabelle C van Gelder, Maarten van Smeden, David van Klaveren, David M Kent, Frans H Rutten, Sander van Doorn

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Percutaneous Left Atrial Appendage Occlusion in Comparison to Non‐Vitamin K Antagonist Oral Anticoagulant Among Patients With Atrial Fibrillation by Peter A. Noseworthy, Holly K. Van Houten, Harlan M. Krumholz, David M. Kent, Neena S. Abraham, Jonathan Graff‐Radford, Mohamad Alkhouli, Henry J. Henk, Nilay D. Shah, Bernard J. Gersh, Paul A. Friedman, David R. Holmes, Xiaoxi Yao

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COVID outcome prediction in the emergency department (COPE): using retrospective Dutch hospital data to develop simple and valid models for predicting mortality and need for intens... by Annelies Verbon, Jelmer Alsma, Hester Lingsma, David M Kent, David van Klaveren, Rozemarijn L van Bruchem-Visser, Tom Dormans, Stephanie C E Schuit, Alexandros Rekkas, Rob J C G Verdonschot, Dick T J J Koning, Marlijn J A Kamps, Robert Stassen, Sebastiaan Weijer, Klaas-Sierk Arnold, Benjamin Tomlow, Hilde R H de Geus, Jelle R Miedema, Els van Nood

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