Prognostic factors for patients with anal cancer treated with conformal radiotherapy—a systematic review by Stelios Theophanous, Robert Samuel, John Lilley, Ann Henry, David Sebag-Montefiore, Alexandra Gilbert, Ane L. Appelt

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Patient-reported outcomes in PROSPECT trial (Alliance N1048) – FOLFOX is not a panacea by Sean M. O'Cathail, Richard Adams, Maria A. Hawkins, David Sebag-Montefiore, Corrie A.M. Marijnen, Emmanouil Fokas

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Three-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control study by Hema Sekhar, Rohit Kochhar, Bernadette Carrington, Thomas Kaye, Damian Tolan, Mark P. Saunders, Matthew Sperrin, David Sebag-Montefiore, Marcel van Herk, Andrew G. Renehan

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A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced... by Séan M. O’Cathail, Steven Davis, Jane Holmes, Richard Brown, Kerry Fisher, Leonard Seymour, Richard Adams, James Good, David Sebag-Montefiore, Tim Maughan, Maria A. Hawkins

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Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study by Ane L. Appelt, Ellen M. Kerkhof, Lars Nyvang, Ernst C. Harderwijk, Natalie L. Abbott, Mark Teo, Femke P. Peters, Camilla J.S. Kronborg, Karen-Lise G. Spindler, David Sebag-Montefiore, Corrie A.M. Marijnen

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Mesorectal radiotherapy for early stage rectal cancer: A novel target volume by Femke P. Peters, Mark T.W. Teo, Ane L. Appelt, Simon Bach, Gunnar Baatrup, Johannes H.W. de Wilt, Camilla Jensenius Kronborg, Karen-Lise Garm Spindler, Corrie A.M. Marijnen, David Sebag-Montefiore

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Patient position verification in magnetic-resonance imaging only radiotherapy of anal and rectal cancers by David Bird, Matthew Beasley, Michael G. Nix, Marcus Tyyger, Hazel McCallum, Mark Teo, Alexandra Gilbert, Nathalie Casanova, Rachel Cooper, David L. Buckley, David Sebag-Montefiore, Richard Speight, Ann M. Henry, Bashar Al-Qaisieh

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Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancre... by Victoria Y. Strauss, Rachel Shaw, Pradeep S. Virdee, Christopher N. Hurt, Elizabeth Ward, Bethan Tranter, Neel Patel, John Bridgewater, Philip Parsons, Ganesh Radhakrishna, Eric O’Neill, David Sebag-Montefiore, Maria Hawkins, Pippa G. Corrie, Timothy Maughan, Somnath Mukherjee

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Brain Re-Irradiation Or Chemotherapy: a phase II randomised trial of re-irradiation and chemotherapy in patients with recurrent glioblastoma (BRIOChe) – protocol for a multi-centre... by Stuart Currie, Alexandra Smith, David Sebag-Montefiore, Helen Bulbeck, Jane Hughes, Susan Short, Eleanor M Hudson, Samantha Noutch, Catherine Parbutt, Louise Murray, Joanne Webster, Sarah R Brown, Florien W Boele, Omar Al-Salihi, Helen Baines, Sharon Fernandez, John Lilley, Finbar Slevin

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Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy by Maxime W. Lafarge, Enric Domingo, Korsuk Sirinukunwattana, Ruby Wood, Leslie Samuel, Graeme Murray, Susan D. Richman, Andrew Blake, David Sebag-Montefiore, Simon Gollins, Eckhard Klieser, Daniel Neureiter, Florian Huemer, Richard Greil, Philip Dunne, Philip Quirke, Lukas Weiss, Jens Rittscher, Tim Maughan, Viktor H. Koelzer

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Bayesian network structure for predicting local tumor recurrence in rectal cancer patients treated with neoadjuvant chemoradiation followed by surgery by Biche Osong, Carlotta Masciocchi, Andrea Damiani, Inigo Bermejo, Elisa Meldolesi, Giuditta Chiloiro, Maaike Berbee, Seok Ho Lee, Andre Dekker, Vincenzo Valentini, Jean-Pierre Gerard, Claus Rödel, Krzysztof Bujko, Cornelis van de Velde, Joakim Folkesson, Aldo Sainato, Robert Glynne-Jones, Samuel Ngan, Morten Brændengen, David Sebag-Montefiore, Johan van Soest

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A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer (APHRODITE): protocol for a multicentre, open-label randomised controlled trial by Nicholas West, Sarah Brown, Alexandra Smith, Mark Saunders, Amanda Webster, David Sebag-Montefiore, Mark Teo, Simon Gollins, Jenny Seligmann, Simon P Bach, Monica Jefford, Alexandra Gilbert, Eleanor M Hudson, Samantha Noutch, Ravi Adapala, Carole Burnett, Alwyn Burrage, Maria Hawkins, Debra Howard, Rohit Kochhar, Edward JD Webb, Ane L Appelt

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Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study by Stelios Theophanous, Per-Ivar Lønne, Ananya Choudhury, Maaike Berbee, Andre Dekker, Kristopher Dennis, Alice Dewdney, Maria Antonietta Gambacorta, Alexandra Gilbert, Marianne Grønlie Guren, Lois Holloway, Rashmi Jadon, Rohit Kochhar, Ahmed Allam Mohamed, Rebecca Muirhead, Oriol Parés, Lukasz Raszewski, Rajarshi Roy, Andrew Scarsbrook, David Sebag-Montefiore, Emiliano Spezi, Karen-Lise Garm Spindler, Baukelien van Triest, Vassilios Vassiliou, Eirik Malinen, Leonard Wee, Ane L. Appelt, on behalf of the atomCAT consortium

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Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictorsResearch in context... by Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Susan Richman, Phil Quirke, Keara Redmond, Aikaterini Chatzipli, Alessandro Barberis, Sylvana Hassanieh, Umair Mahmood, Michael Youdell, Ultan McDermott, Viktor Koelzer, Simon Leedham, Ian Tomlinson, Philip Dunne, Francesca M. Buffa, Timothy S. Maughan, Andrew Blake, Francesca Buffa, Enric Domingo, Geoffrey Higgins, Christopher Holmes, Viktor Koelzer, Simon Leedham, Timothy Maughan, Gillies McKenna, James Robineau, Ian Tomlinson, Michael Youdell, Philip Quirke, Susan Richman, David Sebag-Montefiore, Matthew Seymour, Nicholas West, Philip Dunne, Richard Kennedy, Mark Lawler, Keara Redmond, Manuel Salto-Tellez, Peter Campbell, Aikaterini Chatzipli, Claire Hardy, Ultan McDermott, Simon Bach, Andrew Beggs, Jean-Baptiste Cazier, Gary Middleton, Dion Morton, Celina Whalley, Louise Brown, Richard Kaplan, Graeme Murray, Richard Wilson, Richard Adams, Richard Sullivan, Leslie Samuel, Paul Harkin, Steven Walker, Jim Hill, Chieh-Hsi Wu, Dennis Horgan

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Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units by Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes

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International consensus to define outcomes for trials of chemoradiotherapy for anal cancer (CORMAC-2): defining the outcomes from the CORMAC core outcome set by Robert Samuel, Stephen R. Knight, Richard Adams, Prajnan Das, Jennifer Dorth, David Finch, Marianne G. Guren, Maria A. Hawkins, Susan Moug, Lakshmi Rajdev, David Sebag-Montefiore, Andrew G. Renehan, Rebecca Fish, Miguel A. Rodriguez-Bigas, Pratik Adusumilli, Ahmed Allam Mohamed, Mario Alvarez Gallego, Eva Angenete, Ane Appelt, Maaike Berbee, Danielle Brogden, Peter Brown, Lucy Buckley, Nathalie Casanova, Rachel Cooper, Nuno Couto, Peter Coyne, Tamzin Cuming, Charlotte Deijin, Kristopher Dennis, Cathy Eng, Alexandra Gilbert, Duncan Gilbert, Karyn Goodman, Rashmi Jadon, Anders Johnsson, Arunansu Kar, Ethan Ludmir, Marie-Louise Lydrup, Ivan Lyra-Gonzalez, Stefania Manfrida, Rebecca Muirhead, Sarah O'Dwyer, Thomas Rackley, Lukasz Raszewski, Leslie Samuel, Mark Saunders, Andrew Scarsbrook, Eva Segelov, Timothy Simmons, Paul Sutton, Nicholas Symons, Deborah Williamson

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