Phase Ib Study of the Histone Deacetylase 6 Inhibitor Citarinostat in Combination With Paclitaxel in Patients With Advanced Solid Tumors by Michael S. Gordon, Geoffrey I. Shapiro, John Sarantopoulos, Dejan Juric, Dejan Juric, Brian Lu, Angeliki Zarotiadou, Jamie N. Connarn, Yvan Le Bruchec, Calin Dan Dumitru, R. Donald Harvey

Get full text

Utilizing cell-free DNA to predict risk of developing brain metastases in patients with metastatic breast cancer by Neelima Vidula, Andrzej Niemierko, Katherine Hesler, Lianne Ryan, Beverly Moy, Steven Isakoff, Leif Ellisen, Dejan Juric, Aditya Bardia

Get full text

Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens by Randy J. Giedt, Divya Pathania, Jonathan C. T. Carlson, Philip J. McFarland, Andres Fernandez del Castillo, Dejan Juric, Ralph Weissleder

Get full text

A risk analysis of alpelisib-induced hyperglycemia in patients with advanced solid tumors and breast cancer by Jordi Rodón, David Demanse, Hope S. Rugo, Howard A. Burris, Rafael Simó, Azeez Farooki, Melissa F. Wellons, Fabrice André, Huilin Hu, Dragica Vuina, Cornelia Quadt, Dejan Juric

Get full text

FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma by Yuanli Zhen, Kai Liu, Lei Shi, Simran Shah, Qin Xu, Haley Ellis, Eranga R. Balasooriya, Johannes Kreuzer, Robert Morris, Albert S. Baldwin, Dejan Juric, Wilhelm Haas, Nabeel Bardeesy

Get full text

Detection of microsatellite instability high (MSI-H) status by targeted plasma-based genotyping in metastatic breast cancer by Neelima Vidula, Andrew Lipman, Shumei Kato, Caroline Weipert, Katherine Hesler, Georges Azzi, Ahmed Elkhanany, Dejan Juric, Estelamari Rodriguez, Colleen Faulkner, Paul Makhlouf, Kristin Price, Joyce O’Shaughnessy, Aditya Bardia

Get full text

Phase 1b clinical trial of ado-trastuzumab emtansine and ribociclib for HER2-positive metastatic breast cancer by Laura M. Spring, Shealagh L. Clark, Tianyu Li, Shom Goel, Nabihah Tayob, Elene Viscosi, Elizabeth Abraham, Dejan Juric, Steven J. Isakoff, Erica Mayer, Beverly Moy, Jeffrey G. Supko, Sara M. Tolaney, Aditya Bardia

Get full text

Phase 1 study of M2698, a p70S6K/AKT dual inhibitor, in patients with advanced cancer by Apostolia-Maria Tsimberidou, Jamie V. Shaw, Dejan Juric, Claire Verschraegen, Amy M. Weise, John Sarantopoulos, Gilberto Lopes, John Nemunaitis, Monica Mita, Haeseong Park, Barbara Ellers-Lenz, Hui Tian, Wenyuan Xiong, Remigiusz Kaleta, Razelle Kurzrock

Get full text

Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors by Yan Zhang, Andrés Cervantes, Stephane Champiat, Aurélien Marabelle, Patricia LoRusso, Jason J Luke, Robert Haddad, David J Pinato, Dejan Juric, María de Miguel, Won Seog Kim, Xiaobin Yuan, Peter J Hosein, Anupam M Desai, Yuanxin Rong

Get full text

Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activa... by Erika Hamilton, Dejan Juric, Nora Zizlsperger, Hatem Soliman, Charley Hubbard, Anthony Elias, Brenda C O'Connell, Donna Fitzgerald, Jeffrey L Kutok, Judith Varner, Robert Ilaria, Melody A Cobleigh, Kate H R Tkaczuk, Arielle Lee, Shaker Dakhil, Stephane Peluso

Get full text

1255 Single cell dissection of human checkpoint inhibitor hepatitis reveals insights into liver immune tolerance by Nir Hacohen, Ryan Sullivan, Molly Thomas, John McGuire, Dejan Juric, Leyre Zubiri, Kerry Reynolds, Genevieve M Boland, Alexandra-Chloe Villani, Mazen Nasrallah, Neal Smith, Kasidet Manakongtreecheep, Jessica Tantivit, Alice Tirard, Swetha Ramesh, Tos Chan, Marc Sherman, Georg Lauer, Shreyash Sonthalia

401 Phase 1/2 study of novel HER2-targeting, TLR7/8 immune-stimulating antibody conjugate (ISAC) BDC-1001 with or without immune checkpoint inhibitor in patients with advanced HER2... by Marcin Kowanetz, Manish Sharma, Jeeyun Lee, Leisha Emens, Keun-Wook Lee, Yoon-Koo Kang, Paula Pohlmann, Glenn Hanna, Ecaterina Ileana Dumbrava, Daniel Catenacci, Dejan Juric, Bob Li, Kathleen Moore, Mark Pegram, Antoinette Tan, Shelley Ackerman, Heidi LeBlanc, David Dornan, Michael Alonso, Edith Perez

Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors by Jian Jenny Chen, Melanie Y. Vincent, Dale Shepard, David Peereboom, Devalingam Mahalingam, James Battiste, Manish R. Patel, Dejan Juric, Patrick Y. Wen, Andrea Bullock, Jennifer Eva Selfridge, Shubham Pant, Joyce Liu, Wendy Li, Susanne Fyfe, Suming Wang, Victor Zota, James Mahoney, Randolph S. Watnick, Michael Cieslewicz, Jing Watnick

Get full text

Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique by Emily J. Gallagher, Heather Moore, Mario E. Lacouture, Susan F. Dent, Azeez Farooki, Marcus D. Goncalves, Claudine Isaacs, Abigail Johnston, Dejan Juric, Zoe Quandt, Laura Spring, Brian Berman, Melanie Decker, Gabriel N. Hortobagyi, Benjamin H. Kaffenberger, Bernice Y. Kwong, Timothy Pluard, Ruta Rao, Lee Schwartzberg, Michael S. Broder

Get full text

1252 Immune checkpoint inhibitor-induced diabetes mellitus comprises multiple clinical endotypes with distinct immunologic features by John McGuire, Hoang Tran, Dejan Juric, Leyre Zubiri, Kerry Reynolds, Alexander Gusev, Genevieve M Boland, Caitlin Colling, Sidney Martin, Alexandra-Chloe Villani, Michelle Rengarajan, Alice Tirard, Benjamin Arnold, Karina Ruiz Esteves, Sergio Aguilar Fernandez, Kaitlyn Shank, Aaron Deutsch, Alekhya Gunturi, Nandini Samanta, Katherine Perlman, Tianqi Ouyang, Meghan Sise

A phase Ib study evaluating the recommended phase II dose, safety, tolerability, and efficacy of mivavotinib in combination with nivolumab in advanced solid tumors by Dejan Juric, Minal Barve, Ulka Vaishampayan, Desamparados Roda, Aitana Calvo, Noelia Martinez Jañez, Jose Trigo, Alastair Greystoke, R. Donald Harvey, Anthony J. Olszanski, Mateusz Opyrchal, Alexander Spira, Fiona Thistlethwaite, Begoña Jiménez, Jessica Huck Sappal, Karuppiah Kannan, Jason Riley, Cheryl Li, Cong Li, Richard C. Gregory, Harry Miao, Shining Wang

Get full text

A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-... by Kerry Lynn Reynolds, Philippe L. Bedard, Se-Hoon Lee, Chia-Chi Lin, Josep Tabernero, Maria Alsina, Ezra Cohen, José Baselga, George Blumenschein, Donna M. Graham, Ignacio Garrido-Laguna, Dejan Juric, Sunil Sharma, Ravi Salgia, Abdelkader Seroutou, Xianbin Tian, Rose Fernandez, Alex Morozov, Qing Sheng, Thiruvamoor Ramkumar, Angela Zubel, Yung-Jue Bang

Get full text

Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer by Bernard Pereira, Christopher T. Chen, Lipika Goyal, Charlotte Walmsley, Christopher J. Pinto, Islam Baiev, Read Allen, Laura Henderson, Supriya Saha, Stephanie Reyes, Martin S. Taylor, Donna M. Fitzgerald, Maida Williams Broudo, Avinash Sahu, Xin Gao, Wendy Winckler, A. Rose Brannon, Jeffrey A. Engelman, Rebecca Leary, James R. Stone, Catarina D. Campbell, Dejan Juric

Get full text

Immunogenicity of SARS-CoV-2 vaccines in patients with breast cancer by Elyssa Denault, Erika Nakajima, Vivek Naranbhai, Jennifer A. Hutchinson, Lindsey Mortensen, Elizabeth Neihoff, Caroline Barabell, Amy Comander, Dejan Juric, Irene Kuter, Theresa Mulvey, Jeffrey Peppercorn, Aron S. Rosenstock, Jennifer Shin, Neelima Vidula, Seth A. Wander, Beverly Moy, Leif W. Ellisen, Steven J. Isakoff, A. John Iafrate, Justin F. Gainor, Aditya Bardia, Laura M. Spring

Get full text

Vascular smooth muscle cell phenotype switching in carotid atherosclerosis by Elizabeth L. Chou, MD, Christian L. Lino Cardenas, PharmD, MSc, PhD, Mark Chaffin, MS, Alessandro D. Arduini, PhD, Dejan Juric, MD, James R. Stone, MD, PhD, Glenn M. LaMuraglia, MD, Matthew J. Eagleton, MD, Mark F. Conrad, MD, Eric M. Isselbacher, MD, Patrick T. Ellinor, MD, PhD, Mark E. Lindsay, MD, PhD

Get full text