Dynamic combinatorial mass spectrometry for 2-oxoglutarate oxygenase inhibition by Demetriades, M

Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. by Xu, C, Liu, K, Tempel, W, Demetriades, M, Aik, W, Schofield, C, Min, J

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation by Aik, W, Scotti, J, Choi, H, Gong, L, Demetriades, M, Schofield, C, McDonough, M

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. by Aik, W, Scotti, J, Choi, H, Gong, L, Demetriades, M, Schofield, C, McDonough, M

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. by Leung, I, Demetriades, M, Hardy, A, Lejeune, C, Smart, T, Szöllössi, A, Kawamura, A, Schofield, C, Claridge, T

Structural basis for inhibition of the fat mass and obesity associated protein (FTO). by Aik, W, Demetriades, M, Hamdan, M, Bagg, E, Yeoh, K, Lejeune, C, Zhang, Z, McDonough, M, Schofield, C

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. by Demetriades, M, Leung, I, Chowdhury, R, Chan, M, McDonough, M, Yeoh, K, Tian, Y, Claridge, T, Ratcliffe, P, Woon, E, Schofield, C

On the histone lysine methyltransferase activity of fungal metabolite chaetocin. by Cherblanc, F, Chapman, K, Reid, J, Borg, A, Sundriyal, S, Alcazar-Fuoli, L, Bignell, E, Demetriades, M, Schofield, C, DiMaggio, P, Brown, R, Fuchter, M

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. by Woon, E, Demetriades, M, Bagg, E, Aik, W, Krylova, S, Ma, J, Chan, M, Walport, L, Wegman, D, Dack, K, McDonough, M, Krylov, SN, Schofield, C

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. by Bishop, T, Talbot, N, Turner, P, Nicholls, L, Pascual, A, Hodson, E, Douglas, G, Fielding, J, Smith, T, Demetriades, M, Schofield, C, Robbins, P, Pugh, C, Buckler, K, Ratcliffe, P

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. by Valegård, K, Iqbal, A, Kershaw, N, Ivison, D, Généreux, C, Dubus, A, Blikstad, C, Demetriades, M, Hopkinson, R, Lloyd, A, Roper, D, Schofield, C, Andersson, I, McDonough, M

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. by Yeoh, K, Chan, M, Thalhammer, A, Demetriades, M, Chowdhury, R, Tian, Y, Stolze, I, McNeill, L, Lee, M, Woon, E, Mackeen, M, Kawamura, A, Ratcliffe, P, Mecinović, J, Schofield, C

Structure-based design of selective fat mass and obesity associated protein (FTO) inhibitors by Shishodia, S, Demetriades, M, Zhang, D, Tam, NY, Maheswaran, P, Clunie-O'Connor, C, Tumber, A, Leung, IKH, Ng, YM, Leissing, TM, El-Sagheer, AH, Salah, E, Brown, T, Aik, WS, McDonough, MA, Schofield, CJ

Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain by Chan, MC, Atasoylu, O, Hodson, E, Tumber, A, Leung, IKH, Chowdhury, R, Gómez-Pérez, V, Demetriades, M, Rydzik, AM, Holt-Martyn, J, Tian, Y-M, Bishop, T, Claridge, TDW, Kawamura, A, Pugh, CW, Ratcliffe, PJ, Schofield, CJ

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. by Chowdhury, R, Candela-Lena, J, Chan, M, Greenald, D, Yeoh, K, Tian, Y, McDonough, M, Tumber, A, Rose, N, Conejo-Garcia, A, Demetriades, M, Mathavan, S, Kawamura, A, Lee, M, van Eeden, F, Pugh, C, Ratcliffe, P, Schofield, C

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models by Karuppagounder, S, Alim, I, Khim, S, Bourassa, M, Sleiman, S, John, R, Thinnes, C, Yeh, T, Demetriades, M, Neitemeier, S, Cruz, D, Gazaryan, I, Killilea, D, Morgenstern, L, Xi, G, Keep, R, Schallert, T, Tappero, R, Zhong, J, Cho, S, Maxfield, F, Holman, T, Culmsee, C, Fong, G, Su, Y, Ming, G, Song, H, Cave, J, Schofield, C, Colbourne, F, Coppola, G, Ratan, R