Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors by Giuseppe Deganutti, Silvia Atanasio, Roxana-Maria Rujan, Patrick M. Sexton, Patrick M. Sexton, Denise Wootten, Denise Wootten, Christopher A. Reynolds

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Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening. by Thomas Coudrat, Arthur Christopoulos, Patrick Michael Sexton, Denise Wootten

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Improving virtual screening of G protein-coupled receptors via ligand-directed modeling. by Thomas Coudrat, John Simms, Arthur Christopoulos, Denise Wootten, Patrick M Sexton

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Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics by Laurence J. Miller, Kaleeckal G. Harikumar, Denise Wootten, Patrick M. Sexton

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Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes by Xin Zhang, Matthew J. Belousoff, Yi-Lynn Liang, Radostin Danev, Patrick M. Sexton, Denise Wootten

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Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors by Jessica Lu, Sarah J. Piper, Peishen Zhao, Laurence J. Miller, Denise Wootten, Patrick M. Sexton

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Routine sub-2.5 Å cryo-EM structure determination of GPCRs by Radostin Danev, Matthew Belousoff, Yi-Lynn Liang, Xin Zhang, Fabian Eisenstein, Denise Wootten, Patrick M. Sexton

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Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol by Kaleeckal G. Harikumar, Thomas Coudrat, Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness, Arthur Christopoulos, Arthur Christopoulos, Denise Wootten, Denise Wootten, Eduard A. Sergienko, Patrick M. Sexton, Patrick M. Sexton, Laurence J. Miller

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Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas by Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton, Sebastian G. B. Furness

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Understanding VPAC receptor family peptide binding and selectivity by Sarah J. Piper, Giuseppe Deganutti, Jessica Lu, Peishen Zhao, Yi-Lynn Liang, Yao Lu, Madeleine M. Fletcher, Mohammed Akhter Hossain, Arthur Christopoulos, Christopher A. Reynolds, Radostin Danev, Patrick M. Sexton, Denise Wootten

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Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. by Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton

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Structure and dynamics of the active Gs-coupled human secretin receptor by Maoqing Dong, Giuseppe Deganutti, Sarah J. Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff, Kaleeckal G. Harikumar, Christopher A. Reynolds, Alisa Glukhova, Sebastian G. B. Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M. Sexton, Laurence J. Miller

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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR by Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B. Tobin, Patrick M. Sexton, Steven M. Paul, Christian C. Felder, Radostin Danev, Ron O. Dror, Arthur Christopoulos, Celine Valant, David M. Thal

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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation by Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang, Maryam Khoshouei, Lachlan Clydesdale, Matthew J. Belousoff, Hari Venugopal, Tin T. Truong, Alisa Glukhova, Andrew N. Keller, Karen J. Gregory, Katie Leach, Arthur Christopoulos, Radostin Danev, Christopher A. Reynolds, Peishen Zhao, Patrick M. Sexton, Denise Wootten

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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics by Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Apurba Bhattarai, Wessel AC Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W Lindsley, Andrew Tobin, Patrick Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M Thal

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