4573 Characterization of vascular disease in an Acta2 mutant mouse model by Anita Kaw, Callie Kwartler, Abhijnan Chattopadhyay, Dianna M. Milewicz

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Risk Factors for Thoracic Aortic Dissection by Zhen Zhou, Alana C. Cecchi, Siddharth K. Prakash, Dianna M. Milewicz

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Preventing Acute Aortic Dissections: The Power of Familial Screening and Risk Assessment by Alana C. Cecchi, Maura L. Boerio, Isabella Marin, Amélie Pinard, Dianna M. Milewicz

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Familial aggregation of first degree relatives of children with essential hypertension by Monesha Gupta-Malhotra, Syed Shahrukh Hashmi, Michelle S. Barratt, Dianna M. Milewicz, Sanjay Shete

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Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation by Suravi Majumder, Abhijnan Chattopadhyay, Jamie M. Wright, Pujun Guan, L. Maximilian Buja, Callie S. Kwartler, Dianna M. Milewicz

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Human <i>SMAD4</i> Genomic Variants Identified in Individuals with Heritable and Early-Onset Thoracic Aortic Disease by Shreyas A. Bhave, Dongchuan Guo, Stoyan N. Angelov, Michael J. Bamshad, Deborah A. Nickerson, Dianna M. Milewicz, Mary C. Wallingford

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Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility by Krishna R. Ojha, Hyoseon Kim, Samuel Padgham, Laura Hopkins, Robert J. Zamen, Abhijnan Chattopadhyay, Gang Han, Dianna M. Milewicz, Michael P. Massett, Andreea Trache

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Patient-Specific Modeling Could Predict Occurrence of Pediatric Stroke by John D. Horn, Michael J. Johnson, Zbigniew Starosolski, Zbigniew Starosolski, Avner Meoded, Avner Meoded, Dianna M. Milewicz, Ananth Annapragada, Ananth Annapragada, Shaolie S. Hossain, Shaolie S. Hossain

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Sterols in blood of normal and Smith-Lemli-Opitz subjects by Benfang Ruan, William K. Wilson, Jihai Pang, Nicolas Gerst, Frederick D. Pinkerton, James Tsai, Richard I. Kelley, Frank G. Whitby, Dianna M. Milewicz, James Garbern, George J. Schroepfer, Jr.

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Identification of a common polymorphism in COQ8B acting as a modifier of thoracic aortic aneurysm severity by Benjamin J. Landis, Dongbing Lai, Dong-Chuan Guo, Joel S. Corvera, Muhammad T. Idrees, Henry W. Stadler, Christian Cuevas, Gavin U. Needler, Courtney E. Vujakovich, Dianna M. Milewicz, Robert B. Hinton, Stephanie M. Ware

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Rare deleterious variants of NOTCH1, GATA4, SMAD6, and ROBO4 are enriched in BAV with early onset complications but not in BAV with heritable thoracic aortic disease by Fadi I. Musfee, Dongchuan Guo, Amélie C. Pinard, Ellen M. Hostetler, Elizabeth E. Blue, Deborah A. Nickerson, University of Washington Center for Mendelian Genomics (UW‐CMG), Michael J. Bamshad, Dianna M. Milewicz, Siddharth K. Prakash

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Fatal thoracic aortic aneurysm and dissection in a large family with a novel MYLK gene mutation: delineation of the clinical phenotype by Adel Shalata, Mohammad Mahroom, Dianna M. Milewicz, Gong Limin, Fadi Kassum, Khader Badarna, Nader Tarabeih, Nimmer Assy, Rona Fell, Hector Cohen, Munir Nashashibi, Alejandro Livoff, Muhammad Azab, George Habib, Dan Geiger, Omer Weissbrod, William Nseir

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Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog by Gerburg K. Schwaerzer, Hema Kalyanaraman, Darren E. Casteel, Nancy D. Dalton, Yusu Gu, Seunghoe Lee, Shunhui Zhuang, Nisreen Wahwah, Jan M. Schilling, Hemal H. Patel, Qian Zhang, Ayako Makino, Dianna M. Milewicz, Kirk L. Peterson, Gerry R. Boss, Renate B. Pilz

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Proteomic analysis of descending thoracic aorta identifies unique and universal signatures of aneurysm and dissection by Louis Saddic, MD, PhD, Amanda Orosco, BS, Dongchuan Guo, PhD, Dianna M. Milewicz, MD, PhD, Dana Troxlair, MD, Richard Vander Heide, MD, David Herrington, MD, Yue Wang, PhD, Ali Azizzadeh, MD, Sarah J. Parker, PhD

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Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (Gen... by Mary J. Roman, Norma L. Pugh, Tabitha P. Hendershot, Richard B. Devereux, Hal Dietz, Kathryn Holmes, Kim A. Eagle, Scott A. LeMaire, Dianna M. Milewicz, Shaine A. Morris, Reed E. Pyeritz, William J. Ravekes, Ralph V. Shohet, Michael Silberbach

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Insights From the Histopathologic Analysis of Acquired and Genetic Thoracic Aortic Aneurysms and Dissections by L. Maximilian Buja, MD, Bihong Zhao, MD, PhD, Humaira Sadaf, MD, Michelle McDonald, DO, Ana M. Segura, MD, Li Li, MD, PhD, Alana Cecchi, MS, Siddharth K. Prakash, MD, Rana O. Afifi, MD, Charles C. Miller, PhD, Anthony L. Estrera, MD, Dianna M. Milewicz, MD, PhD

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Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections. by Shao-Qing Kuang, Dong-Chuan Guo, Siddharth K Prakash, Merry-Lynn N McDonald, Ralph J Johnson, Min Wang, Ellen S Regalado, Ludivine Russell, Jiu-Mei Cao, Callie Kwartler, Kurt Fraivillig, Joseph S Coselli, Hazim J Safi, Anthony L Estrera, Suzanne M Leal, Scott A LeMaire, John W Belmont, Dianna M Milewicz, GenTAC Investigators

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Vertebral Tortuosity Is Associated With Increased Rate of Cardiovascular Events in Vascular Ehlers‐Danlos Syndrome by Sara B. Stephens, Sherene Shalhub, Nicholas Dodd, Jesse Li, Michael Huang, Seitaro Oda, Kalyan Kancherla, Tam T. Doan, Siddharth K. Prakash, Justin D. Weigand, Federico M. Asch, Taylor Beecroft, Alana Cecchi, Teniola Shittu, Liliana Preiss, Scott A. LeMaire, Richard B. Devereux, Reed E. Pyeritz, Kathryn W. Holmes, Mary J. Roman, Ronald V. Lacro, Ralph V. Shohet, Rajesh Krishnamurthy, Kim Eagle, Peter Byers, Dianna M. Milewicz, Shaine A. Morris

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Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. by Enrique Audain, Anna Wilsdon, Jeroen Breckpot, Jose M G Izarzugaza, Tomas W Fitzgerald, Anne-Karin Kahlert, Alejandro Sifrim, Florian Wünnemann, Yasset Perez-Riverol, Hashim Abdul-Khaliq, Mads Bak, Anne S Bassett, D Woodrow Benson, Felix Berger, Ingo Daehnert, Koenraad Devriendt, Sven Dittrich, Piers Ef Daubeney, Vidu Garg, Karl Hackmann, Kirstin Hoff, Philipp Hofmann, Gregor Dombrowsky, Thomas Pickardt, Ulrike Bauer, Bernard D Keavney, Sabine Klaassen, Hans-Heiner Kramer, Christian R Marshall, Dianna M Milewicz, Scott Lemaire, Joseph S Coselli, Michael E Mitchell, Aoy Tomita-Mitchell, Siddharth K Prakash, Karl Stamm, Alexandre F R Stewart, Candice K Silversides, Reiner Siebert, Brigitte Stiller, Jill A Rosenfeld, Inga Vater, Alex V Postma, Almuth Caliebe, J David Brook, Gregor Andelfinger, Matthew E Hurles, Bernard Thienpont, Lars Allan Larsen, Marc-Phillip Hitz

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Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. by Enrique Audain, Anna Wilsdon, Jeroen Breckpot, Jose M G Izarzugaza, Tomas W Fitzgerald, Anne-Karin Kahlert, Alejandro Sifrim, Florian Wünnemann, Yasset Perez-Riverol, Hashim Abdul-Khaliq, Mads Bak, Anne S Bassett, D Woodrow Benson, Felix Berger, Ingo Daehnert, Koenraad Devriendt, Sven Dittrich, Piers Ef Daubeney, Vidu Garg, Karl Hackmann, Kirstin Hoff, Philipp Hofmann, Gregor Dombrowsky, Thomas Pickardt, Ulrike Bauer, Bernard D Keavney, Sabine Klaassen, Hans-Heiner Kramer, Christian R Marshall, Dianna M Milewicz, Scott Lemaire, Joseph S Coselli, Michael E Mitchell, Aoy Tomita-Mitchell, Siddharth K Prakash, Karl Stamm, Alexandre F R Stewart, Candice K Silversides, Reiner Siebert, Brigitte Stiller, Jill A Rosenfeld, Inga Vater, Alex V Postma, Almuth Caliebe, J David Brook, Gregor Andelfinger, Matthew E Hurles, Bernard Thienpont, Lars Allan Larsen, Marc-Phillip Hitz

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