How to tackle antimalarial resistance? od Didier Leroy

Dokumenty pełnotekstowe

Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin od Lucien Platon, Didier Leroy, David A. Fidock, Didier Ménard

Dokumenty pełnotekstowe

Comparison and Optimization of Different Methods for the In Vitro Production of Plasmodium falciparum Gametocytes od María Roncalés, Jaume Vidal-Mas, Didier Leroy, Esperanza Herreros

Dokumenty pełnotekstowe

Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay od Annabelle Walz, Didier Leroy, Nicole Andenmatten, Pascal Mäser, Sergio Wittlin

Dokumenty pełnotekstowe

Mouse Model of Respiratory Tract Infection Induced by Waddlia chondrophila. od Ludovic Pilloux, Didier LeRoy, Christophe Brunel, Thierry Roger, Gilbert Greub

Dokumenty pełnotekstowe

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay. od Joël Lelièvre, Maria Jesus Almela, Sonia Lozano, Celia Miguel, Virginia Franco, Didier Leroy, Esperanza Herreros

Dokumenty pełnotekstowe

Host-directed therapy, an untapped opportunity for antimalarial intervention od Ling Wei, Jack Adderley, Didier Leroy, David H. Drewry, Danny W. Wilson, Alexis Kaushansky, Christian Doerig

Dokumenty pełnotekstowe

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. od Michael Delves, David Plouffe, Christian Scheurer, Stephan Meister, Sergio Wittlin, Elizabeth A Winzeler, Robert E Sinden, Didier Leroy

Dokumenty pełnotekstowe

Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs od Franziska Mohring, Donelly A. van Schalkwyk, Ryan C. Henrici, Benjamin Blasco, Didier Leroy, Colin J. Sutherland, Robert W. Moon

Dokumenty pełnotekstowe

Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages od Michael Delves, Michael Delves, M. Jose Lafuente-Monasterio, Leanna Upton, Andrea Ruecker, Andrea Ruecker, Andrea Ruecker, Didier Leroy, Francisco-Javier Gamo, Robert Sinden

Dokumenty pełnotekstowe

Plasmodium knowlesi exhibits distinct in vitro drug susceptibility profiles from those of Plasmodium falciparum od Donelly A. van Schalkwyk, Benjamin Blasco, Rocio Davina Nuñez, Jonathan W.K. Liew, Amirah Amir, Yee L. Lau, Didier Leroy, Robert W. Moon, Colin J. Sutherland

Dokumenty pełnotekstowe

Screening a protein kinase inhibitor library against Plasmodium falciparum od Irene Hallyburton, Raffaella Grimaldi, Andrew Woodland, Beatriz Baragaña, Torsten Luksch, Daniel Spinks, Daniel James, Didier Leroy, David Waterson, Alan H. Fairlamb, Paul G. Wyatt, Ian H. Gilbert, Julie A. Frearson

Dokumenty pełnotekstowe

Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials od Mariska Naude, Ashleigh van Heerden, Janette Reader, Mariëtte van der Watt, Jandeli Niemand, Dorè Joubert, Giulia Siciliano, Pietro Alano, Mathew Njoroge, Kelly Chibale, Esperanza Herreros, Didier Leroy, Lyn-Marié Birkholtz

Dokumenty pełnotekstowe

Defining the next generation of severe malaria treatment: a target product profile od Jane Achan, Aïssata Barry, Didier Leroy, George Kamara, Stephan Duparc, Wiweka Kaszubska, Preetam Gandhi, Bénédicte Buffet, Patrick Tshilab, Bernhards Ogutu, Terrie Taylor, Sanjeev Krishna, Naomi Richardson, Hanu Ramachandruni, Hans Rietveld

Dokumenty pełnotekstowe

The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of <i>Plasmodium falciparum</i> Viability after Antimalarial Treatment In Vitro od Annabelle Walz, Maëlle Duffey, Ghaith Aljayyoussi, Sibylle Sax, Didier Leroy, Dominique Besson, Jeremy N. Burrows, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Marie-Anne Westwood, Christoph Siethoff, Francisco-Javier Gamo, Pascal Mäser, Sergio Wittlin

Dokumenty pełnotekstowe

African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker od Didier Leroy, Fiona Macintyre, Yeka Adoke, Serge Ouoba, Aissata Barry, Ghyslain Mombo-Ngoma, Jacques Mari Ndong Ngomo, Rosauro Varo, Yannelle Dossou, Antoinette Kitoto Tshefu, Tran Thanh Duong, Bui Quang Phuc, Bart Laurijssens, Roland Klopper, Nimol Khim, Eric Legrand, Didier Ménard

Dokumenty pełnotekstowe

A new in vivo screening paradigm to accelerate antimalarial drug discovery. od María Belén Jiménez-Díaz, Sara Viera, Javier Ibáñez, Teresa Mulet, Noemí Magán-Marchal, Helen Garuti, Vanessa Gómez, Lorena Cortés-Gil, Antonio Martínez, Santiago Ferrer, María Teresa Fraile, Félix Calderón, Esther Fernández, Leonard D Shultz, Didier Leroy, David M Wilson, José Francisco García-Bustos, Francisco Javier Gamo, Iñigo Angulo-Barturen

Dokumenty pełnotekstowe

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. od Gregory J Crowther, Heidi K Hillesland, Katelyn R Keyloun, Molly C Reid, Maria Jose Lafuente-Monasterio, Sonja Ghidelli-Disse, Stephen E Leonard, Panqing He, Jackson C Jones, Mallory M Krahn, Jack S Mo, Kartheek S Dasari, Anna M W Fox, Markus Boesche, Majida El Bakkouri, Kasey L Rivas, Didier Leroy, Raymond Hui, Gerard Drewes, Dustin J Maly, Wesley C Van Voorhis, Kayode K Ojo

Dokumenty pełnotekstowe

A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquin... od Fiona Macintyre, Yeka Adoke, Alfred B. Tiono, Tran Thanh Duong, Ghyslain Mombo-Ngoma, Marielle Bouyou-Akotet, Halidou Tinto, Quique Bassat, Saadou Issifou, Marc Adamy, Helen Demarest, Stephan Duparc, Didier Leroy, Bart E. Laurijssens, Sophie Biguenet, Afizi Kibuuka, Antoinette Kitoto Tshefu, Melnick Smith, Chanelle Foster, Illse Leipoldt, Peter G. Kremsner, Bui Quang Phuc, Alphonse Ouedraogo, Michael Ramharter, on behalf of the OZ-Piperaquine Study Group

Dokumenty pełnotekstowe

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults... od Yeka Adoke, Rella Zoleko-Manego, Serge Ouoba, Alfred B. Tiono, Grace Kaguthi, Juvêncio Eduardo Bonzela, Tran Thanh Duong, Alain Nahum, Marielle Bouyou-Akotet, Bernhards Ogutu, Alphonse Ouedraogo, Fiona Macintyre, Andreas Jessel, Bart Laurijssens, Mohammed H. Cherkaoui-Rbati, Cathy Cantalloube, Anne Claire Marrast, Raphaël Bejuit, David White, Timothy N. C. Wells, Florian Wartha, Didier Leroy, Afizi Kibuuka, Ghyslain Mombo-Ngoma, Daouda Ouattara, Irène Mugenya, Bui Quang Phuc, Francis Bohissou, Denise P. Mawili-Mboumba, Fredrick Olewe, Issiaka Soulama, Halidou Tinto, the FALCI Study Group

Dokumenty pełnotekstowe