Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference by Chantal M. Ferguson, Dimas Echeverria, Matthew Hassler, Socheata Ly, Anastasia Khvorova

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Dry Bean: A Protein-Rich Superfood With Carbohydrate Characteristics That Can Close the Dietary Fiber Gap by Mark A. Brick, Adrienne Kleintop, Dimas Echeverria, Sara Kammlade, Leslie A. Brick, Juan M. Osorno, Phillip McClean, Henry J. Thompson

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2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA by Sarah M. Davis, Jacquelyn Sousa, Lorenc Vangjeli, Matthew R. Hassler, Dimas Echeverria, Emily Knox, Anton A. Turanov, Julia F. Alterman, Anastasia Khvorova

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Genetic Architecture of Dietary Fiber and Oligosaccharide Content in a Middle American Panel of Edible Dry Bean by Samira Mafi Moghaddam, Mark A. Brick, Dimas Echeverria, Henry J. Thompson, Leslie A. Brick, Rian Lee, Sujan Mamidi, Phillip E. McClean

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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain by Mehran Nikan, Maire F Osborn, Andrew H Coles, Bruno MDC Godinho, Lauren M Hall, Reka A Haraszti, Matthew R Hassler, Dimas Echeverria, Neil Aronin, Anastasia Khvorova

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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing by Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, Erik J. Sontheimer

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Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors by Shun-Yun Cheng, Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh, Matthew Hassler, Samson Jolly, Delaney Giguere, Joris Cipi, Anastasia Khvorova, Claudio Punzo

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Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1 by Sarah M. Davis, Vignesh N. Hariharan, Agnes Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova

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Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity by Hassan H. Fakih, Qi Tang, Ashley Summers, Minwook Shin, Julianna E. Buchwald, Rosemary Gagnon, Vignesh N. Hariharan, Dimas Echeverria, David A. Cooper, Jonathan K. Watts, Anastasia Khvorova, Hanadi F. Sleiman

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PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs by Bruno M.D.C. Godinho, Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy, Reka A. Haraszti, Chantal M. Ferguson, Andrew H. Coles, Annabelle Biscans, Jillian Caiazzi, Julia F. Alterman, Matthew R. Hassler, Anastasia Khvorova

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Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis by Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M Harney, Chloe DiMarzio, Hui Wang, Nicholas McHugh, Brianna Bramato, Brett Morrison, Jeffery D Rothstein, Anastasia Khvorova, Michael P Czech

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Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models by Faith Conroy, Rachael Miller, Julia F. Alterman, Matthew R. Hassler, Dimas Echeverria, Bruno M. D. C. Godinho, Emily G. Knox, Ellen Sapp, Jaquelyn Sousa, Ken Yamada, Farah Mahmood, Adel Boudi, Kimberly Kegel-Gleason, Marian DiFiglia, Neil Aronin, Anastasia Khvorova, Edith L. Pfister

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition by Reka Agnes Haraszti, Rachael Miller, Michelle L. Dubuke, Hannah E. Rockwell, Andrew H. Coles, Ellen Sapp, Marie-Cecile Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John Leszyk, Julia F. Alterman, Bruno M.D.C. Godinho, Matthew R. Hassler, Justice McDaniel, Niven R. Narain, Rachel Wollacott, Yang Wang, Scott A. Shaffer, Michael A. Kiebish, Marian DiFiglia, Neil Aronin, Anastasia Khvorova

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Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin by Qi Tang, Hassan H. Fakih, Mohammad Zain UI Abideen, Samuel R. Hildebrand, Khashayar Afshari, Katherine Y. Gross, Jacquelyn Sousa, Allison S. Maebius, Christina Bartholdy, Pia Pernille Søgaard, Malene Jackerott, Vignesh Hariharan, Ashley Summers, Xueli Fan, Ken Okamura, Kathryn R. Monopoli, David A. Cooper, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, Raymond C. Furgal, Karen Dresser, Sarah J. Winter, Annabelle Biscans, Jane Chuprin, Nazgol-Sadat Haddadi, Shany Sherman, Ümmügülsüm Yıldız-Altay, Mehdi Rashighi, Jillian M. Richmond, Claire Bouix-Peter, Carine Blanchard, Adam Clauss, Julia F. Alterman, Anastasia Khvorova, John E. Harris

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