Neurologic immune-related adverse events associated with adjuvant ipilimumab: report of two cases by Christine A. Garcia, Alex El-Ali, Tanya J. Rath, Lydia C. Contis, Vikram Gorantla, Jan Drappatz, Diwakar Davar

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Immune-Related Adverse Events in PD-1 Treated Melanoma and Impact Upon Anti-Tumor Efficacy: A Real World Analysis by Melissa L. Bastacky, Hong Wang, Dylan Fortman, Zahra Rahman, Gerard P. Mascara, Timothy Brenner, Yana G. Najjar, Yana G. Najjar, Jason J. Luke, Jason J. Luke, John M. Kirkwood, John M. Kirkwood, Hassane M. Zarour, Hassane M. Zarour, Diwakar Davar, Diwakar Davar

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Phase I trial of pembrolizumab plus vemurafenib and cobimetinib in patients with metastatic melanoma by Saba S. Shaikh, Saba S. Shaikh, Yan Zang, Janel Hanmer, Hong Wang, Yan Lin, Diwakar Davar, Hassane M. Zarour, John M. Kirkwood, Yana G. Najjar

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1322 Too sweet to be true: sucralose ablates immunotherapy response through microbiome disruption by Jishnu Das, Greg Delgoffe, Diwakar Davar, Stacy Wendell, Hector Nieves-Rosado, Bingxian Xie, Kristin Morder, Abigail E Overacre-Delgoffe, Drew Wilfahrt, Douglas Prado, Madison Nguyen, William Hawse, Larry Kane

596 AMBER, Part 2B: a phase 1 study of cobolimab plus dostarlimab in patients with advanced/metastatic non-small cell lung cancer (NSCLC) previously treated with anti-PD(L)-1 thera... by Antoni Ribas, Mohammed Milhem, Diwakar Davar, Patricia LoRusso, Zeynep Eroglu, Martin Gutierrez, Arindam Dhar, Carlos Becerra, Brian Di Pace, Tianli Wang, Hailei Zhang, Srimoyee Ghosh, Shyam Srivats, Theo Borgovan, Angela Waszak

782 TransCon TLR7/8 agonist induces sustained local and systemic immune activation in patients with solid tumors by David Bajor, Nashat Gabrail, Alain Algazi, Diwakar Davar, Douglas Laux, Morteza Aghmesheh, Joan Morris, Vinod Ganju, Vibeke Miller Breinholt, Mette Kriegbaum, Alexander I Spira, Christian Krapp, Telma Lança, Stina Singel, Thomas Tuxen Poulsen

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression by Yuliya V. Katlinskaya, Kanstantsin V. Katlinski, Qiujing Yu, Angelica Ortiz, Daniel P. Beiting, Angela Brice, Diwakar Davar, Cindy Sanders, John M. Kirkwood, Hallgeir Rui, Xiaowei Xu, Constantinos Koumenis, J. Alan Diehl, Serge Y. Fuchs

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888 Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma by Riyue Bao, Hassane Zarour, Yana G Najjar, Diwakar Davar, Cindy Sander, Jason J Luke, John M Kirkwood, Ryan C Augustin, Aofei Li, Marion Joy, Maureen Lyons, Katelyn Smith, Brian Isett, Sarah Brodeur, Mary Pham, Peter C Lucas

Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma by Riyue Bao, Yana G Najjar, Diwakar Davar, Cindy Sander, John M Kirkwood, Jason John Luke, Sarah Newman, Hassane M Zarour, Peter Lucas, Ryan C Augustin, Aofei Li, Marion Joy, Maureen Lyons, Mary P Pham, Katelyn Smith, Brian Isett

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Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study by Ryan C. Augustin, Ryan C. Augustin, Ziyu Huang, Fei Ding, Shuyan Zhai, Jennifer McArdle, Anthony Santisi, Michael Davis, Cindy Sander, Diwakar Davar, John M. Kirkwood, John M. Kirkwood, Greg M. Delgoffe, Allison Betof Warner, Yana G. Najjar, Yana G. Najjar

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777 Initial results from an open-label phase 1b/2 study of RP1 oncolytic immunotherapy in solid organ and hematopoietic cell transplant recipients with advanced cutaneous malignanc... by Gregory A Daniels, Diwakar Davar, Theresa Medina, Michael R Migden, Trisha M Wise-Draper, Andrew S Poklepovic, Claire Verschraegen, Wanxing Chai-Ho, Jennifer C Tang, Praveen K Bommareddy, Shaheer A Khan, Katy K Tsai, Meenal Kheterpal, Diana Bolotin, Sherrif F Ibrahim, Nathalie C Zeitouni, Chris Tucci, Susan Navia, Laxminarasimha Donthireddy, Jeannie W Hou

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0 by Omid Hamid, Diwakar Davar, Benjamin Izar, Charlotte E Ariyan, Michael K Wong, Jason J Luke, Janis M Taube, Anna C Pavlick, Meghan J Mooradian, Douglas B Johnson, Hussein A Tawbi, Tara C Mitchell, Ryan J Sullivan, April KS Salama, Krista M Rubin, Elizabeth I Buchbinder, Sarah A Weiss, Tina J Hieken, Geoffrey T Gibney, Rajan P Kulkarni, J Keith Tolley, Caressa Valdueza

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1534 Clinical activity of SD-101 with immune checkpoint inhibition (ICI) in metastatic uveal melanoma liver metastasis (MUM-LM) from the PERIO-01 Phase 1 trial by David Geller, Ashley Moody, Richard Carvajal, Cara Haymaker, Sunil Reddy, Jose Lutzky, Shailender Bhatia, Diwakar Davar, Bartosz Chmielowski, Theresa Medina, Eric Wehrenberg-Klee, Marlana Orloff, Rahul Sheth, Sapna P Patel, Robert Knight, Jason Laporte, Prajna Guha, Bryan Cox, Steven Katz, Paula Novelli, Joshua D Kuban, Ann-Marie Hulstine, Kamaneh Montazeri, Shaheer A Khan, Lindsay Thornton, Anthony Lucci, Vanessa Sarli, Salyna Meas, Chandra C Ghosh

Society for Immunotherapy of Cancer (SITC) recommendations on intratumoral immunotherapy clinical trials (IICT): from premalignant to metastatic disease by Bart Neyns, Mark Middleton, Aurélien Marabelle, Ignacio Melero, Ke Liu, Nina Bhardwaj, Tanja D de Gruijl, Jason Chesney, Robert Coffin, Howard Kaufman, Diwakar Davar, Jason J Luke, Georgina V Long, Kevin J Harrington, Sherene Loi, Thierry de Baere, David J Pinato, Matthew Fury, Ciara M Kelly, Joshua D Brody, Robert H Andtbacka, Gregory Goldmacher, Anuradha D Khilnani, Rahul A Sheth, Stephen B Solomon, Philippe Szapary

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Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes by Lilit Karapetyan, Hassan M. AbuShukair, Aofei Li, Andrew Knight, Ayah Nedal Al Bzour, Ian P. MacFawn, Zachary J. Thompson, Ann Chen, Xi Yang, Rebekah Dadey, Arivarasan Karunamurthy, Danielle Vargas De Stefano, Cindy Sander, Sheryl R. Kunning, Yana G. Najjar, Diwakar Davar, Jason J. Luke, William Gooding, Tullia C. Bruno, Tullia C. Bruno, John M. Kirkwood, John M. Kirkwood, Walter J. Storkus, Walter J. Storkus

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Tim-3 mediates T cell trogocytosis to limit antitumor immunity by Ornella Pagliano, Robert M. Morrison, Joe-Marc Chauvin, Hridesh Banerjee, Diwakar Davar, Quanquan Ding, Tokiyoshi Tanegashima, Wentao Gao, Saranya R. Chakka, Richelle DeBlasio, Ava Lowin, Kevin Kara, Mignane Ka, Bochra Zidi, Rada Amin, Itay Raphael, Shuowen Zhang, Simon C. Watkins, Cindy Sander, John M. Kirkwood, Marcus Bosenberg, Ana C. Anderson, Vijay K. Kuchroo, Lawrence P. Kane, Alan J. Korman, Arvind Rajpal, Sean M. West, Minhua Han, Christine Bee, Xiaodi Deng, Xiao Min Schebye, Pavel Strop, Hassane M. Zarour

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