Editorial for the Special Issue: “State-of-Art in Protein Engineering” by Lada E. Petrovskaya, Dmitry A. Dolgikh

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Recent Advances in the Development of Nanodelivery Systems Targeting the TRAIL Death Receptor Pathway by Anne V. Yagolovich, Marine E. Gasparian, Dmitry A. Dolgikh

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Corrigendum: Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL by Artem A. Artykov, Anne V. Yagolovich, Anne V. Yagolovich, Dmitry A. Dolgikh, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Mikhail P. Kirpichnikov, Daria B. Trushina, Marine E. Gasparian

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The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception by Valentina E. Bychkova, Dmitry A. Dolgikh, Vitalii A. Balobanov, Alexei V. Finkelstein

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Molecular Interactions between Neuroglobin and Cytochrome <i>c:</i> Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells by Marina A. Semenova, Rita V. Chertkova, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh

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Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects by Vladislav S. Rybchenko, Teimur K. Aliev, Anna A. Panina, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh

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Optimized Heterologous Expression and Efficient Purification of a New TRAIL-Based Antitumor Fusion Protein SRH–DR5-B with Dual VEGFR2 and DR5 Receptor Specificity by Anne V. Yagolovich, Artem A. Artykov, Alina A. Isakova, Yekaterina V. Vorontsova, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Marine E. Gasparian

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GFP–Margatoxin, a Genetically Encoded Fluorescent Ligand to Probe Affinity of Kv1.3 Channel Blockers by Kristina R. Denisova, Nikita A. Orlov, Sergey A. Yakimov, Elena A. Kryukova, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Alexey V. Feofanov, Oksana V. Nekrasova

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Chemotherapeutic Agents Sensitize Resistant Cancer Cells to the DR5-Specific Variant DR5-B More Efficiently Than to TRAIL by Modulating the Surface Expression of Death and Decoy Re... by Artem A. Artykov, Dmitry A. Belov, Victoria O. Shipunova, Daria B. Trushina, Sergey M. Deyev, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Marine E. Gasparian

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Bispecific Antibodies for IFN-β Delivery to ErbB2⁺ Tumors by Vladislav S. Rybchenko, Anna A. Panina, Teimur K. Aliev, Olga N. Solopova, Dmitry S. Balabashin, Valery N. Novoseletsky, Dmitry A. Dolgikh, Petr G. Sveshnikov, Mikhail P. Kirpichnikov

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Kinetics and Energetics of Intramolecular Electron Transfer in Single-Point Labeled TUPS-Cytochrome <em>c</em> Derivatives by Petro Khoroshyy, Katalin Tenger, Rita V. Chertkova, Olga V. Bocharova, Mikhail P. Kirpichnikov, Natalia Borovok, Géza I. Groma, Dmitry A. Dolgikh, Alexander B. Kotlyar, László Zimányi

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Engineering of Thermal Stability in a Cold-Active Oligo-1,6-Glucosidase from <i>Exiguobacterium sibiricum</i> with Unusual Amino Acid Content by Yana Y. Berlina, Lada E. Petrovskaya, Elena A. Kryukova, Lyudmila N. Shingarova, Sultan Sh. Gapizov, Mariya V. Kryukova, Elizaveta M. Rivkina, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh

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Oriented Insertion of ESR-Containing Hybrid Proteins in Proteoliposomes by Lada E. Petrovskaya, Evgeniy P. Lukashev, Mahir D. Mamedov, Elena A. Kryukova, Sergei P. Balashov, Dmitry A. Dolgikh, Andrei B. Rubin, Mikhail P. Kirpichnikov, Sergey A. Siletsky

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Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile by Anne V. Yagolovich, Artem A. Artykov, Tatiana A. Karmakova, Maria S. Vorontsova, Andrey A. Pankratov, Alexander A. Andreev-Andrievsky, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Marine E. Gasparian

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New insight into the mechanism of mitochondrial cytochrome c function. by Rita V Chertkova, Nadezda A Brazhe, Tatiana V Bryantseva, Alexey N Nekrasov, Dmitry A Dolgikh, Alexander I Yusipovich, Olga Sosnovtseva, Georgy V Maksimov, Andrei B Rubin, Mikhail P Kirpichnikov

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Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models by Anna L. Luss, Dmitry V. Bagrov, Anne V. Yagolovich, Ekaterina V. Kukovyakina, Irina I. Khan, Vadim S. Pokrovsky, Maria V. Shestovskaya, Marine E. Gasparian, Dmitry A. Dolgikh, Andrey N. Kuskov

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Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine. by Konstantin M Boyko, Marya V Kryukova, Lada E Petrovskaya, Alena Y Nikolaeva, Dmitry A Korzhenevsky, Ksenia A Novototskaya-Vlasova, Elizaveta M Rivkina, Dmitry A Dolgikh, Mikhail P Kirpichnikov, Vladimir O Popov

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Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties by Rita V. Chertkova, Ilya P. Oleynikov, Alexey A. Pakhomov, Roman V. Sudakov, Victor N. Orlov, Marina A. Semenova, Alexander M. Arutyunyan, Vasily V. Ptushenko, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Tatiana V. Vygodina

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Amino Acid Substitutions in the Non-Ordered Ω-Loop 70–85 Affect Electron Transfer Function and Secondary Structure of Mitochondrial Cytochrome <i>c</i> by Rita V. Chertkova, Tatyana V. Bryantseva, Nadezhda A. Brazhe, Kseniya S. Kudryashova, Victor V. Revin, Alexei N. Nekrasov, Alexander I. Yusipovich, Alexey R. Brazhe, Andrew B. Rubin, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Georgy V. Maksimov

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Structural and Biochemical Characterization of a Cold-Active PMGL3 Esterase with Unusual Oligomeric Structure by Konstantin M. Boyko, Mariya V. Kryukova, Lada E. Petrovskaya, Elena A. Kryukova, Alena Y. Nikolaeva, Dmitry A. Korzhenevsky, Galina Yu. Lomakina, Ksenia A. Novototskaya-Vlasova, Elizaveta M. Rivkina, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Vladimir O. Popov

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