Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition. by Dunford, J

An epigenetic screen identifies bromodomain-containing protein 4 (BRD4) as a critical component for osteoblast differentiation by Kramm, A, Kubicek, S, Dunford, J, Oppermann, U

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7. by Stambergova, H, Skarydova, L, Dunford, J, Wsol, V

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. by Kavanagh, K, Dunford, J, Bunkoczi, G, Russell, R, Oppermann, U

Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. by Peach, C, Zhang, Y, Dunford, J, Brown, M, Carr, A

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. by Kavanagh, K, Dunford, J, Bunkoczi, G, Russell, R, Oppermann, U

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells by Räikkönen, J, Taskinen, M, Dunford, J, Mönkkönen, H, Auriola, S, Mönkkönen, J

Why do some patients fail to respond to bisphosphonate therapy: Identification of a novel polymorphism in exon 11 of FPP synthase by Roemelt, C, McGuigan, F, Dunford, J, Ablagha, O, Rogers, M

Polymorphic variation in the FPP synthase (FPPS) gene and effects on bisphosphonate inhibition by Roemelt, C, McGuigan, F, Dunford, J, Albagha, O, Rogers, M

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. by Räikkönen, J, Taskinen, M, Dunford, J, Mönkkönen, H, Auriola, S, Mönkkönen, J

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates by Dunford, J, Kavanagh, K, Rogers, M, Opperinann, U, Ebetino, F, Russell, R

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates. by Dunford, J, Kavanagh, K, Oppermann, U, Ebetino, E, Russell, R, Rogers, M

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates by Dunford, J, Kavanagh, K, Oppermann, U, Ebetino, F, Russell, R, Rogers, M

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates by Dunford, J, Kavanagh, K, Rogers, M, Oppermann, U, Ebetin, F, Russell, G

Alendronate and ibandronate affect osteoclast formation and size differently from risedronate and zoledronate by Mabilleau, G, Kwaasi, A, Tsoumpra, M, Sabokbar, A, Dunford, J, Ebetino, F, Russell, R

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities by Xia, Z, Dunford, J, Lawson, M, Triffitt, J, Barnett, B, Ebetino, F, Russell, R

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 23... by Tsoumpra, M, Barnett, B, Kwaasi, A, Walters, R, Ebetino, F, Russell, R, Oppermann, U, Dunford, J

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate syntha... by Dunford, J, Kwaasi, A, Rogers, M, Barnett, B, Ebetino, F, Russell, R, Oppermann, U, Kavanagh, K

Directed differentiation of human induced pluripotent stem cells into chondrocytes by Hala, S, Yapp, C, Kramm, A, Carpenter, L, Watt, S, Carr, A, Dunford, J, Oppermann, U, Tirlapur, U

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs). by Ebetino, F, Rogers, M, Dunford, J, Liu, X, Phipps, R, Russell, R, Mieling, G, Barnett, B