Integrative structural biology of viruses nork Duyvesteyn, HME

Structural insights into Frizzled3 through nanobody modulators nork Hillier, J, Zhao, Y, Carrique, L, Malinauskas, T, Ruza, RR, Chang, T, Yi, G, Duyvesteyn, HME, Yu, J, Lu, W, Pardon, E, Steyaert, J, Zhu, Y, Ni, T, Jones, EY

Accelerating drug target inhibitor discovery with a deep generative foundation model nork Chenthamarakshan, V, Hoffman, SC, Owen, CD, Lukacik, P, Strain-Damerell, C, Fearon, D, Malla, TR, Tumber, A, Schofield, CJ, Duyvesteyn, HME, Dejnirattisai, W, Carrique, L, Walter, TS, Screaton, GR, Matviiuk, T, Mojsilovic, A, Crain, J, Walsh, MA, Stuart, DI, Das, P

Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines nork Sherry, L, Bahar, MW, Porta, C, Fox, H, Grehan, K, Nasta, V, Duyvesteyn, HME, De Colibus, L, Marsian, J, Murdoch, I, Ponndorf, D, Kim, S, Shah, S, Carlyle, S, Swanson, JJ, Matthews, S, Nicol, C, Lomonossoff, GP, Macadam, AJ, Fry, EE, Stuart, DI, Stonehouse, NJ, Rowlands, DJ

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants nork Liu, C, Zhou, D, Nutalai, R, Duyvesteyn, HME, Tuekprakhon, A, Ginn, HM, Dejnirattisai, W, Supasa, P, Mentzer, AJ, Wang, B, Case, JB, Zhao, Y, Skelly, DT, Chen, RE, Johnson, SA, Ritter, TG, Mason, C, Malik, T, Temperton, N, Paterson, NG, Williams, MA, Hall, DR, Clare, DK, Howe, A, Goulder, PJR, Fry, EE, Diamond, MS, Mongkolsapaya, J, Ren, J, Stuart, DI, Screaton, GR

Potent cross-reactive antibodies following Omicron breakthrough in vaccinees nork Nutalai, R, Zhou, D, Tuekprakhon, A, Ginn, HM, Supasa, P, Liu, C, Huo, J, Mentzer, AJ, Duyvesteyn, HME, Dijokaite-Guraliuc, A, Skelly, D, Ritter, TG, Amini, A, Bibi, S, Adele, S, Johnson, SA, Constantinides, B, Webster, H, Temperton, N, Klenerman, P, Barnes, E, Dunachie, SJ, Crook, D, Pollard, AJ, Lambe, T, Goulder, P, Paterson, NG, Williams, MA, Hall, DR, Mongkolsapaya, J, Fry, EE, Dejnirattisai, W, Ren, J, Stuart, DI, Screaton, GR

Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum nork Tuekprakhon, A, Nutalai, R, Dijokaite-Guraliuc, A, Zhou, D, Ginn, HM, Selvaraj, M, Liu, C, Mentzer, AJ, Supasa, P, Duyvesteyn, HME, Das, R, Skelly, D, Ritter, TG, Amini, A, Bibi, S, Adele, S, Johnson, SA, Constantinides, B, Webster, H, Temperton, N, Klenerman, P, Barnes, E, Dunachie, SJ, Crook, D, Pollard, AJ, Lambe, T, Goulder, P, Paterson, NG, Williams, MA, Hall, DR, ISARIC4C Consortium, Fry, EE, Huo, J, Mongkolsapaya, J, Ren, J, Stuart, DI, Screaton, GR

A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75 nork Huo, J, Dijokaite-Guraliuc, A, Liu, C, Zhou, D, Ginn, HM, Das, R, Supasa, P, Selvaraj, M, Nutalai, R, Tuekprakhon, A, Duyvesteyn, HME, Mentzer, AJ, Skelly, D, Ritter, TG, Amini, A, Bibi, S, Adele, S, Johnson, SA, Paterson, NG, Williams, MA, Hall, DR, Plowright, M, Newman, TAH, Hornsby, H, de Silva, TI, Temperton, N, Klenerman, P, Barnes, E, Dunachie, SJ, Pollard, AJ, Lambe, T, Goulder, P, OPTIC consortium, ISARIC4C consortium, Fry, EE, Mongkolsapaya, J, Ren, J, Stuart, DI, Screaton, GR

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera nork Zhou, D, Dejnirattisai, W, Supasa, P, Liu, C, Mentzer, AJ, Ginn, HM, Zhao, Y, Duyvesteyn, HME, Tuekprakhon, A, Nutalai, R, Wang, B, Paesen, GC, Lopez-Camacho, C, Slon-Campos, J, Hallis, B, Coombes, N, Bewley, K, Charlton, S, Walter, TS, Skelly, D, Lumley, SF, Dold, C, Levin, R, Pollard, AJ, Dong, T, Knight, JC, Crook, D, Lambe, T, Clutterbuck, E, Bibi, S, Flaxman, A, Bittaye, M, Belij-Rammerstorfer, S, Gilbert, S, James, W, Carroll, MW, Klenerman, P, Barnes, E, Dunachie, SJ, Fry, EE, Mongkolsapaya, J, Ren, J, Stuart, DI, Screaton, GR

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient nork Zhou, D, Duyvesteyn, HME, Chen, C-P, Huang, C-G, Chen, T-H, Shih, S-R, Lin, Y-C, Cheng, C-Y, Cheng, S-H, Huang, Y-C, Lin, T-Y, Ma, C, Huo, J, Carrique, L, Malinauskas, T, Ruza, RR, Shah, PNM, Tan, TK, Rijal, P, Donat, RF, Godwin, K, Buttigieg, KR, Tree, JA, Radecke, J, Paterson, NG, Supasa, P, Mongkolsapaya, J, Screaton, GR, Carroll, MW, Gilbert-Jaramillo, J, Knight, ML, James, W, Owens, RJ, Naismith, JH, Townsend, AR, Fry, EE, Zhao, Y, Ren, J, Stuart, DI, Huang, K-YA

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera nork Supasa, P, Zhou, D, Dejnirattisai, W, Liu, C, Mentzer, AJ, Ginn, HM, Zhao, Y, Duyvesteyn, HME, Nutalai, R, Tuekprakhon, A, Wang, B, Paesen, GC, Slon-Campos, J, López-Camacho, C, Hallis, B, Coombes, N, Bewley, KR, Charlton, S, Walter, TS, Barnes, E, Dunachie, SJ, Skelly, D, Lumley, SF, Baker, N, Shaik, I, Humphries, HE, Godwin, K, Gent, N, Sienkiewicz, A, Dold, C, Levin, R, Pollard, AJ, Dong, T, Screaton, GR, Knight, JC, Klenerman, P, Crook, D, Lambe, T, Clutterbuck, E, Bibi, S, Flaxman, A, Bittaye, M, Belij-Rammerstorfer, S, Gilbert, S, Hall, DR, Williams, MA, Paterson, NG, James, W, Carroll, MW, Fry, EE, Mongkolsapaya, J, Stuart, DI

Antibody evasion by the P.1 strain of SARS-CoV-2 nork Dejnirattisai, W, Zhou, D, Supasa, P, Liu, C, Mentzer, AJ, Ginn, HM, Zhao, Y, Duyvesteyn, HME, Tuekprakhon, A, Nutalai, R, Wang, B, López-Camacho, C, Slon-Campos, J, Walter, TS, Skelly, D, Costa Clemens, SA, Naveca, FG, Nascimento, V, Nascimento, F, Fernandes da Costa, C, Resende, PC, Pauvolid-Correa, A, Siqueira, MM, Dold, C, Levin, R, Dong, T, Pollard, AJ, Knight, JC, Crook, D, Lambe, T, Clutterbuck, E, Bibi, S, Flaxman, A, Bittaye, M, Belij-Rammerstorfer, S, Gilbert, SC, Carroll, MW, Klenerman, P, Barnes, E, Dunachie, SJ, Paterson, NG, Williams, MA, Hall, DR, Hulswit, RJG, Bowden, TA, Fry, EE, Mongkolsapaya, J, Ren, J, Stuart, DI, Screaton, GR

The antigenic anatomy of SARS-CoV-2 receptor binding domain nork Dejnirattisai, W, Zhou, D, Ginn, HM, Duyvesteyn, HME, Spasa, D, Case, JB, Zhao, Y, Walter, TS, Mentzer, AJ, Liu, C, Wang, B, Paesen, GC, Slon-Campus, J, López-Camacho, C, Kafai, NM, Bailey, AL, Chen, RE, Ying, B, Thompson, C, Bolton, J, Fyfe, A, Gupta, S, Tan, TK, Gilbert-Jaramillo, J, James, W, Knight, M, Carroll, MW, Skelly, D, Dold, C, Peng, Y, Levin, R, Dong, T, Pollard, AJ, Knight, JC, Klenerman, P, Temperton, N, Hall, DR, Williams, MA, Paterson, NG, Bertram, FKR, Seibert, CA, Clare, DK, Howe, A, Raedecke, J, Song, Y, Townsend, AR, Huang, K-YA, Fry, EE, Mongkolsapaya, J, Diamond, MS, Ren, J, Stuart, DI, Screaton, GR

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses nork Dejnirattisai, W, Huo, J, Zhou, D, Zahradník, J, Supasa, P, Liu, C, Duyvesteyn, HME, Ginn, HM, Mentzer, AJ, Tuekprakhon, A, Nutalai, R, Wang, B, Dijokaite, A, Khan, S, Avinoam, O, Bahar, M, Skelly, D, Adele, S, Johnson, SA, Amini, A, Ritter, TG, Mason, C, Dold, C, Pan, D, Assadi, S, Bellass, A, Omo-Dare, N, Koeckerling, D, Flaxman, A, Jenkin, D, Aley, PK, Voysey, M, Costa Clemens, SA, Naveca, FG, Nascimento, V, Nascimento, F, Fernandes da Costa, C, Resende, PC, Pauvolid-Correa, A, Siqueira, MM, Baillie, V, Serafin, N, Kwatra, G, Da Silva, K, Madhi, SA, Nunes, MC, Malik, T, Openshaw, PJM, Baillie, JK, Semple, MG, Dunachie, SJ, Lambe, T, Screaton, GR, Pollard, AJ

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum nork Liu, C, Ginn, HM, Dejnirattisai, W, Supasa, P, Wang, B, Tuekprakhon, A, Nutalai, R, Zhou, D, Mentzer, AJ, Zhao, Y, Duyvesteyn, HME, López-Camacho, C, Slon-Campos, J, Walter, TS, Skelly, D, Johnson, SA, Ritter, TG, Mason, C, Costa Clemens, SA, Gomes Naveca, F, Nascimento, V, Nascimento, F, Fernandes da Costa, C, Resende, PC, Pauvolid-Correa, A, Siqueira, MM, Dold, C, Temperton, N, Dong, T, Pollard, AJ, Knight, JC, Crook, D, Lambe, T, Clutterbuck, E, Bibi, S, Flaxman, A, Bittaye, M, Belij-Rammerstorfer, S, Gilbert, SC, Malik, T, Carroll, MW, Klenerman, P, Barnes, E, Dunachie, SJ, Baillie, V, Serafin, N, Ditse, Z, Da Silva, K, Paterson, NG, Williams, MA, Goulder, P, Fry, EE, Ren, J, Stuart, DI, Screaton, GR